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Biochimica et biophysica acta
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biosynthesis
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Subject term
pyridoxal phosphate
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- Author:
- Anthony J. Romo; Hung-wen Liu
- Source:
- Biochimica et biophysica acta 2011 v.1814 no.11 pp. 1534-1547
- ISSN:
- 1878-1454
- Subject:
- bioactive properties; biosynthesis; catalytic activity; crystal structure; deoxysugars; enzymatic reactions; enzymology; pyridoxal phosphate; transaminases; transamination
- Abstract:
- ... PLP is well-regarded for its role as a coenzyme in a number of diverse enzymatic reactions. Transamination, deoxygenation, and aldol reactions mediated by PLP-dependent enzymes enliven and enrich deoxy sugar biosynthesis, endowing these compounds with unique structures and contributing to their roles as determinants of biological activity in many natural products. The importance of deoxy aminosuga ...
- DOI:
- 10.1016/j.bbapap.2011.02.003
- PubMed:
- 21315852
- PubMed Central:
- PMC3115481
- https://doi.org/10.1016/j.bbapap.2011.02.003
- Author:
- Hiroko Ikushiro; Hideyuki Hayashi
- Source:
- Biochimica et biophysica acta 2011 v.1814 no.11 pp. 1474-1480
- ISSN:
- 1878-1454
- Subject:
- biosynthesis; pyridoxal phosphate; sphingolipids; spectroscopy; enzymology; serine C-palmitoyltransferase
- Abstract:
- ... Serine palmitoyltransferase, which is one of the α-oxamine synthase family enzymes, catalyzes the condensation reaction of L-serine and palmitoyl-CoA to form 3-ketodihydrosphingosine, the first and rate-determining step of the sphingolipid biosynthesis. As with other α-oxamine synthase family enzymes, the catalytic reaction is composed of multiple elementary steps, and the mechanism to control the ...
- DOI:
- 10.1016/j.bbapap.2011.02.005
- https://doi.org/10.1016/j.bbapap.2011.02.005
- Author:
- Gregory A. Hunter; Gloria C. Ferreira
- Source:
- Biochimica et biophysica acta 2011 v.1814 no.11 pp. 1467-1473
- ISSN:
- 1878-1454
- Subject:
- 5-aminolevulinate synthase; active sites; amino acids; anemia; biochemical pathways; biosynthesis; catalytic activity; dissociation; energy; enzymology; fungi; gene expression regulation; heme; humans; mitochondria; mutation; pyridoxal phosphate
- Abstract:
- ... Pyridoxal-5'-phosphate (PLP) is an obligatory cofactor for the homodimeric mitochondrial enzyme 5-aminolevulinate synthase (ALAS), which controls metabolic flux into the porphyrin biosynthetic pathway in animals, fungi, and the α-subclass of proteobacteria. Recent work has provided an explanation for how this enzyme can utilize PLP to catalyze the mechanistically unusual cleavage of not one but tw ...
- DOI:
- 10.1016/j.bbapap.2010.12.015
- PubMed:
- 21215825
- PubMed Central:
- PMC3090494
- https://doi.org/10.1016/j.bbapap.2010.12.015
- Author:
- Tathagata Mukherjee; Jeremiah Hanes; Ivo Tews; Steven E. Ealick; Tadhg P. Begley
- Source:
- Biochimica et biophysica acta 2011 v.1814 no.11 pp. 1585-1596
- ISSN:
- 1878-1454
- Subject:
- biosynthesis; chemical reactions; enzymes; enzymology; fungi; oxidative stress; protective effect; pyridoxal phosphate; pyridoxine; singlet oxygen
- Abstract:
- ... Vitamin B₆ is an essential cofactor that participates in a large number of biochemical reactions. Pyridoxal phosphate is biosynthesized de novo by two different pathways (the DXP dependent pathway and the R5P pathway) and can also be salvaged from the environment. It is one of the few cofactors whose catabolic pathway has been comprehensively characterized. It is also known to function as a single ...
- DOI:
- 10.1016/j.bbapap.2011.06.018
- https://doi.org/10.1016/j.bbapap.2011.06.018
- Author:
- Robert Schnell; Dharmarajan Sriram; Gunter Schneider
- Source:
- Biochimica et biophysica acta 2015 v.1854 no.9 pp. 1175-1183
- ISSN:
- 1570-9639
- Subject:
- Bacilli; Mycobacterium tuberculosis; antibiotics; biosynthesis; cysteine; cysteine synthase; drug resistance; drug therapy; drugs; free radicals; homeostasis; lungs; nitrogen; oxygen; pathogen survival; proteins; pyridoxal phosphate; relapse; sulfur; tuberculosis
- Abstract:
- ... The alarming increase of drug resistance in Mycobacterium tuberculosis strains poses a severe threat to human health. Chemotherapy is particularly challenging because M. tuberculosis can persist in the lungs of infected individuals; estimates of the WHO indicate that about 1/3 of the world population is infected with latent tuberculosis providing a large reservoir for relapse and subsequent spread ...
- DOI:
- 10.1016/j.bbapap.2014.11.010
- https://doi.org/10.1016/j.bbapap.2014.11.010
- Author:
- Bosko M. Stojanovski; Leonid Breydo; Vladimir N. Uversky; Gloria C. Ferreira
- Source:
- Biochimica et biophysica acta 2016 v.1864 no.5 pp. 441-452
- ISSN:
- 1570-9639
- Subject:
- 5-aminolevulinate synthase; algorithms; biosynthesis; blood; catalytic activity; cytosol; denaturation; eukaryotic cells; heme; mice; molecular weight; physiological transport; proteolysis; pyridoxal; pyridoxal phosphate; thermal stability; topology
- Abstract:
- ... 5-Aminolevulinate synthase (ALAS), a pyridoxal 5′-phosphate (PLP)-dependent homodimeric enzyme, catalyzes the initial step of heme biosynthesis in non-plant eukaryotes. The precursor form of the enzyme is translated in the cytosol, and upon mitochondrial import, the N-terminal targeting presequence is proteolytically cleaved to generate mature ALAS. In bone marrow-derived erythroid cells, a mitoch ...
- DOI:
- 10.1016/j.bbapap.2016.02.002
- https://doi.org/10.1016/j.bbapap.2016.02.002
- Author:
- Annalisa Michielon; Francesco Marchesani; Serena Faggiano; Roberta Giaccari; Barbara Campanini; Stefano Bettati; Andrea Mozzarelli; Stefano Bruno
- Source:
- Biochimica et biophysica acta 2021 v.1869 no.1 pp. 140544
- ISSN:
- 1570-9639
- Subject:
- aldehydes; biosynthesis; enantiomers; glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase; humans; ligands; mice; pyridoxal phosphate; serine; serine racemase
- Abstract:
- ... Murine serine racemase (SR), the enzyme responsible for the biosynthesis of the neuromodulator d-serine, was reported to form a complex with glyceraldehyde 3-phosphate dehydrogenase (GAPDH), resulting in SR inhibition. In this work, we investigated the interaction between the two human orthologues. We were not able to observe neither the inhibition nor the formation of the SR-GAPDH complex. Rather ...
- DOI:
- 10.1016/j.bbapap.2020.140544
- https://doi.org/10.1016/j.bbapap.2020.140544