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- David García-Seisdedos; Bohdan Babiy; Milagros Lerma; María E. Casado; Javier Martínez-Botas; Miguel A. Lasunción; Óscar Pastor; Rebeca Busto
- Biochimica et biophysica acta 2020 v.1865 no.5 pp. 158638
- Curcuma longa; animal models; ceramides; curcumin; enzyme inhibitors; exosomes; fumonisin B1; hydrophobicity; mice; neuroglia; polyphenols; rhizomes; secretion; serine C-palmitoyltransferase; sphingosine N-acyltransferase
- ... Curcumin, a hydrophobic polyphenol found in the rhizome of Curcuma longa, has been shown to reduce intracellular lipid accumulation in mouse models of lysosomal storage diseases such as Niemann-Pick type C. Exosomes are small extracellular vesicles secreted by cells in response to changes in intracellular ceramide composition. Curcumin can induce exosome/microvesicle release in cellular models of ...
- Igor Zlobine; Keshav Gopal; John R. Ussher
- Biochimica et biophysica acta 2016 v.1861 no.10 pp. 1555-1568
- acyl coenzyme A; animal models; beta oxidation; cardiomyopathy; ceramides; coronary artery disease; diacylglycerols; fatty acids; heart; humans; hypertension; lipotoxicity; noninsulin-dependent diabetes mellitus; obesity; pathophysiology; patients; risk; toxicity; triacylglycerols
- ... Patients with type 2 diabetes (T2D) are at increased risk for cardiovascular diseases including diabetic cardiomyopathy, which is ventricular dysfunction independent of underlying coronary artery disease and/or hypertension. With numerous advancements in our ability to detect ventricular dysfunction, as well as the molecular mechanisms contributing to ventricular dysfunction in diabetic patients, ...