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- Author:
- Aditi Chaudhari; Liliana Håversen; Reza Mobini; Linda Andersson; Marcus Ståhlman; Emma Lu; Mikael Rutberg; Per Fogelstrand; Kim Ekroos; Adil Mardinoglu; Malin Levin; Rosie Perkins; Jan Borén
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.11 pp. 1643-1651
- ISSN:
- 1388-1981
- Subject:
- GTPase-activating proteins; biosynthesis; ceramides; fatty acids; gene expression; glucose; glucose transporters; microarray technology; plasma membrane; proteome; triacylglycerols
- Abstract:
- ... Lipid droplet formation, which is driven by triglyceride synthesis, requires several droplet-associated proteins. We identified ARAP2 (an ADP-ribosylation factor 6 GTPase-activating protein) in the lipid droplet proteome of NIH-3T3 cells and showed that knockdown of ARAP2 resulted in decreased lipid droplet formation and triglyceride synthesis. We also showed that ARAP2 knockdown did not affect fa ...
- DOI:
- 10.1016/j.bbalip.2016.07.009
- https://doi.org/10.1016/j.bbalip.2016.07.009
- Author:
- Guangbi Li; Dandan Huang; Owais M. Bhat; Justin L. Poklis; Aolin Zhang; Yao Zou; Jason Kidd; Todd W.B. Gehr; Pin-Lan Li
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.2 pp. 158856
- ISSN:
- 1388-1981
- Subject:
- calcium; ceramides; excretion; exosomes; gene deletion; gene expression; gene targeting; genes; immunohistochemistry; knockout mutants; lysosomes; nephrotic syndrome; pathogenesis; protein subunits; secretion; sphingosine
- Abstract:
- ... Podocytopathy and associated nephrotic syndrome (NS) have been reported in a knockout mouse strain (Asah1ᶠˡ/ᶠˡ/PodoCʳᵉ) with a podocyte-specific deletion of α subunit (the main catalytic subunit) of acid ceramidase (Ac). However, the pathogenesis of podocytopathy of these mice remains unknown. The present study tested whether exosome release from podocytes is enhanced due to Asah1 gene knockout, w ...
- DOI:
- 10.1016/j.bbalip.2020.158856
- https://doi.org/10.1016/j.bbalip.2020.158856
- Author:
- Ayumi Kato; Mana Ito; Takao Sanaki; Tomohiko Okuda; Noriko Tsuchiya; Ryo Yoshimoto; Hideo Yukioka
- Source:
- Biochimica et biophysica acta 2022 v.1867 no.2 pp. 159085
- ISSN:
- 1388-1981
- Subject:
- acyl coenzyme A; adipose tissue; biosynthesis; ceramides; embryonic mortality; energy metabolism; enzymes; heart; linoleic acid; skeletal muscle; triacylglycerols
- Abstract:
- ... The long-chain acyl-CoA synthase1 (Acsl1) is a major enzyme that converts long-chain fatty acids to acyl-CoAs. The role of Acsl1 in energy metabolism has been elucidated in the adipose tissue, heart, and skeletal muscle. Here, we demonstrate that systemic deficiency of Acsl1 caused severe skin barrier defects, leading to embryonic lethality. Acsl1 mRNA and protein are expressed in the Acsl1⁺/⁺ epi ...
- DOI:
- 10.1016/j.bbalip.2021.159085
- https://doi.org/10.1016/j.bbalip.2021.159085
- Author:
- Maryam Rakhshandehroo; Robert J. van Eijkeren; Tanit L. Gabriel; Colin de Haar; Sanne M.W. Gijzel; Nicole Hamers; Maria J. Ferraz; Johannes M.F.G. Aerts; Henk S. Schipper; Marco van Eijk; Marianne Boes; Eric Kalkhoven
- Source:
- Biochimica et biophysica acta 2019 v.1864 no.8 pp. 1157-1167
- ISSN:
- 1388-1981
- Subject:
- adipocytes; adipose tissue; antigen-presenting cells; antigens; biochemical pathways; biosynthesis; cell communication; cell lines; ceramide glucosyltransferase; ceramides; coculture; energy; glucosylceramides; homeostasis; insulin resistance; interleukin-4; metabolites; secretion
- Abstract:
- ... Natural killer T (NKT) cells in adipose tissue (AT) contribute to whole body energy homeostasis.Inhibition of the glucosylceramide synthesis in adipocytes impairs iNKT cell activity.Glucosylceramide biosynthesis pathway is important for endogenous lipid antigen activation of iNKT cells in adipocytes.Unraveling adipocyte-iNKT cell communication may help to fight obesity-induced AT dysfunction.Overp ...
- DOI:
- 10.1016/j.bbalip.2019.04.016
- https://doi.org/10.1016/j.bbalip.2019.04.016
- Author:
- Valentina Vozella; Abdul Basit; Alessandra Misto; Daniele Piomelli
- Source:
- Biochimica et biophysica acta 2017 v.1862 no.12 pp. 1502-1511
- ISSN:
- 1388-1981
- Subject:
- biosynthesis; cell biology; ceramides; females; gene expression regulation; hippocampus; liquid chromatography; males; mass spectrometry; mice; nervonic acid; neurodegenerative diseases; quantitative polymerase chain reaction; sphingomyelins; stearoyl-CoA desaturase
- Abstract:
- ... Sphingolipids have been implicated in age-related neurodegeneration. Previous studies have reported elevated ceramide levels in the brain of old rodents, but a systematic investigation of the impact of age on brain sphingolipid metabolism is still lacking. Here we quantified 17 key sphingolipid species in the hippocampus of young (3months), middle-aged (12months) and old (21months) male and female ...
- DOI:
- 10.1016/j.bbalip.2017.08.008
- https://doi.org/10.1016/j.bbalip.2017.08.008
- Author:
- Li Jiao; Hongying Gan-Schreier; Xingya Zhu; Wang Wei; Sabine Tuma-Kellner; Gerhard Liebisch; Wolfgang Stremmel; Walee Chamulitrat
- Source:
- Biochimica et biophysica acta 2017 v.1862 no.12 pp. 1520-1533
- ISSN:
- 1388-1981
- Subject:
- apoptosis; atrophy; bile; bile acids; body weight changes; brain; ceramides; colitis; fibrosis; gene expression; genes; genetic background; hydrophobicity; intestines; liver; liver cirrhosis; males; metabolism; mice; mutants; pathogenesis; phenotype; phospholipase A2; phospholipids; receptors; risk factors; tight junctions
- Abstract:
- ... Ageing is a major risk factor for various forms of liver and gastrointestinal (GI) disease and genetic background may contribute to the pathogenesis of these diseases. Group VIA phospholipase A2 or iPLA2β is a homeostatic PLA2 by playing a role in phospholipid metabolism and remodeling. Global iPLA2β⁻/⁻ mice exhibit aged-dependent phenotypes with body weight loss and abnormalities in the bone and ...
- DOI:
- 10.1016/j.bbalip.2017.09.001
- https://doi.org/10.1016/j.bbalip.2017.09.001
- Author:
- Lisa Rein-Fischboeck; Elisabeth M. Haberl; Rebekka Pohl; Verena Schmid; Susanne Feder; Sabrina Krautbauer; Gerhard Liebisch; Christa Buechler
- Source:
- Biochimica et biophysica acta 2018 v.1863 pp. 526-537
- ISSN:
- 1388-1981
- Subject:
- adipocytes; adipose tissue; ceramides; cholesterol; diet; droplets; fatty liver; genes; genotype; immigration; liver; macrophages; malondialdehyde; mice; models; mutants; oxidative stress; pathogenesis; phosphatidylethanolamines; phosphatidylserines; protective effect; proteins; sphingomyelins
- Abstract:
- ... Adipose tissue dysfunction contributes to the pathogenesis of non-alcoholic steatohepatitis (NASH). The adapter protein alpha-syntrophin (SNTA) is expressed in adipocytes. Knock-down of SNTA increases preadipocyte proliferation and formation of small lipid droplets, which are both characteristics of healthy adipose tissue. To elucidate a potential protective role of SNTA in NASH, SNTA null mice we ...
- DOI:
- 10.1016/j.bbalip.2018.02.006
- https://doi.org/10.1016/j.bbalip.2018.02.006
- Author:
- Martin Reichel; Stefanie Hönig; Gerhard Liebisch; Anja Lüth; Burkhard Kleuser; Erich Gulbins; Gerd Schmitz; Johannes Kornhuber
- Source:
- Biochimica et biophysica acta 2015 v.1851 no.11 pp. 1501-1510
- ISSN:
- 1388-1981
- Subject:
- alcohol abuse; alcohols; biomarkers; ceramides; correlation; electrospray ionization mass spectrometry; lysophosphatidylcholine; males; metabolism; patients; phosphatidylethanolamines; poisoning; risk factors; sphingomyelins
- Abstract:
- ... Alcohol abuse is a major risk factor for somatic and neuropsychiatric diseases. Despite their potential clinical importance, little is known about the alterations of plasma glycerophospholipid (GPL) and sphingolipid (SPL) species associated with alcohol abuse.Plasma GPL and SPL species were quantified using electrospray ionization tandem mass spectrometry in samples from 23 male alcohol-dependent ...
- DOI:
- 10.1016/j.bbalip.2015.08.005
- https://doi.org/10.1016/j.bbalip.2015.08.005
- Author:
- Davide Noto; Francesca Di Gaudio; Ida Grazia Altieri; Angelo Baldassare Cefalù; Sergio Indelicato; Francesca Fayer; Rossella Spina; Chiara Scrimali; Antonina Giammanco; Alessandro Mattina; Serena Indelicato; Massimiliano Greco; David Bongiorno; Maurizio Averna
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.6 pp. 158656
- ISSN:
- 1388-1981
- Subject:
- algorithms; automation; biomarkers; cell culture; ceramides; glucose; hepatocytes; hepatoma; insulin resistance; isotope labeling; lipid metabolism; long chain triacylglycerols; models; palmitates; palmitic acid; sphingomyelins; stable isotopes
- Abstract:
- ... Untargeted lipidomics is a powerful tool to discover new biomarkers and to understand the physiology and pathology of lipids. The use of stable isotopes as tracers to investigate the kinetics of lipids is another tool able to supply dynamic information on lipid synthesis and catabolism. Coupling the two methodology is then very appealing in the study of lipid metabolism. The main issue to face is ...
- DOI:
- 10.1016/j.bbalip.2020.158656
- https://doi.org/10.1016/j.bbalip.2020.158656
10. Ceramide and polyunsaturated phospholipids are strongly reduced in human hepatocellular carcinoma
- Author:
- Sabrina Krautbauer; Elisabeth M. Meier; Lisa Rein-Fischboeck; Rebekka Pohl; Thomas S. Weiss; Alexander Sigruener; Charalampos Aslanidis; Gerhard Liebisch; Christa Buechler
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.11 pp. 1767-1774
- ISSN:
- 1388-1981
- Subject:
- blood lipids; blood serum; cell death; cell proliferation; ceramides; cholesterol; correlation; cytotoxicity; hepatocytes; hepatoma; humans; lipid composition; lysophosphatidylcholine; macrophages; noninsulin-dependent diabetes mellitus; patients; phosphatidylethanolamines; sphingomyelins; tissues
- Abstract:
- ... Lipid composition affects membrane function, cell proliferation and cell death and is changed in cancer tissues. Hepatocellular carcinoma (HCC) is an aggressive cancer and this study aimed at a comprehensive characterization of hepatic and serum lipids in human HCC. Cholesteryl ester were higher in tumorous tissues (TT) compared to adjacent non-tumorous tissues (NT). Free cholesterol exerting cyto ...
- DOI:
- 10.1016/j.bbalip.2016.08.014
- https://doi.org/10.1016/j.bbalip.2016.08.014
- Author:
- Vitor Teixeira; Tânia C. Medeiros; Rita Vilaça; João Ferreira; Pedro Moradas-Ferreira; Vítor Costa
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.1 pp. 21-33
- ISSN:
- 1388-1981
- Subject:
- H-transporting ATP synthase; acidification; autophagy; ceramides; digestion; gene expression regulation; homeostasis; mammals; models; phenotype; proteolysis; signal transduction; vacuoles; yeasts
- Abstract:
- ... The vacuoles play important roles in cellular homeostasis and their functions include the digestion of cytoplasmic material and organelles derived from autophagy. Conserved nutrient signaling pathways regulate vacuolar function and autophagy, ensuring normal cell and organismal development and aging. Recent evidence implicates sphingolipids in the modulation of these processes, but the impact of c ...
- DOI:
- 10.1016/j.bbalip.2015.10.004
- https://doi.org/10.1016/j.bbalip.2015.10.004
- Author:
- Masayuki Sugimoto; Yoichi Shimizu; Songji Zhao; Naoyuki Ukon; Ken-ichi Nishijima; Masato Wakabayashi; Takeshi Yoshioka; Kenichi Higashino; Yoshito Numata; Tomohiko Okuda; Nagara Tamaki; Hisatoshi Hanamatsu; Yasuyuki Igarashi; Yuji Kuge
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.8 pp. 688-702
- ISSN:
- 1388-1981
- Subject:
- blood; ceramides; glucose; high fat diet; insulin; insulin resistance; liver; metabolism; mice; obesity; radiolabeling; skeletal muscle; sphingomyelins; very long chain fatty acids; white adipose tissue
- Abstract:
- ... Sphingomyelin synthase 2 (SMS2) is a proposed potential therapeutic target for obesity and insulin resistance. However, the contributions of SMS2 to glucose metabolism in tissues and its possible therapeutic mechanisms remain unclear. Thus, to determine whole-body glucose utilization and the contributions of each insulin-targeted tissue to glucose uptake, we performed a glucose kinetics study, usi ...
- DOI:
- 10.1016/j.bbalip.2016.04.019
- https://doi.org/10.1016/j.bbalip.2016.04.019
- Author:
- Sebastian Brachtendorf; Ruth Anna Wanger; Kerstin Birod; Dominique Thomas; Sandra Trautmann; Marthe-Susanna Wegner; Dominik C. Fuhrmann; Bernhard Brüne; Gerd Geisslinger; Sabine Grösch
- Source:
- Biochimica et biophysica acta 2018 v.1863 no.10 pp. 1214-1227
- ISSN:
- 1388-1981
- Subject:
- autophagy; ceramides; colorectal neoplasms; drug therapy; fluorouracil; humans; messenger RNA; mitochondria; neoplasm cells; sphingosine N-acyltransferase
- Abstract:
- ... Resistance against chemotherapy is a life-threatening complication in colon cancer therapy. To increase response rate, new additional targets that contribute to chemoresistance are still needed to be explored. Ceramides, which belong to the group of sphingolipids, are well-known regulators of cell death and survival, respectively. Here, we show that in human wild-type (ʷᵗ) p53 HCT-116 colon cancer ...
- DOI:
- 10.1016/j.bbalip.2018.07.011
- https://doi.org/10.1016/j.bbalip.2018.07.011
- Author:
- Iva Žebrakovská; Martin Máša; Jaroslav Srp; Martin Horn; Kateřina Vávrová; Michael Mareš
- Source:
- Biochimica et biophysica acta 2011 v.1811 no.12 pp. 1097-1104
- ISSN:
- 1388-1981
- Subject:
- apoptosis; bioactive properties; cathepsin D; ceramides; fluorescence; humans; neurodegenerative diseases; proteolysis
- Abstract:
- ... Cathepsin D is an aspartic peptidase involved in cellular processes including proliferation and apoptosis and implicated in human pathologies such as cancer and neurodegeneration. Our knowledge about the relationship between proteolysis and bioactive sphingolipids is still very limited. Here, we describe a complex pattern of modulation of the peptidolytic activity of cathepsin D by sphingolipids. ...
- DOI:
- 10.1016/j.bbalip.2011.09.005
- https://doi.org/10.1016/j.bbalip.2011.09.005
- Author:
- T. Berkers; W.A. Boiten; S. Absalah; J. van Smeden; A.P.M. Lavrijsen; J.A. Bouwstra
- Source:
- Biochimica et biophysica acta 2019 v.1864 no.8 pp. 1103-1108
- ISSN:
- 1388-1981
- Subject:
- ceramides; humans; lipid composition; models; skin (animal); skin diseases
- Abstract:
- ... Ex vivo regenerated stratum corneum (SC) after tape-stripping can be used as a model to study the barrier function of compromised skin. Yet, details about how close the regenerated SC model mimics the lipid properties (e.g. lipid composition and lipid ordering) of the in vivo situation are not known. Here, we examined using a comprehensive ceramide analysis whether human ex vivo regenerated SC sho ...
- DOI:
- 10.1016/j.bbalip.2019.04.005
- https://doi.org/10.1016/j.bbalip.2019.04.005
- Author:
- Timon Eckes; Sandra Trautmann; Sonja Djudjaj; Sandra Beyer; Sammy Patyna; Stephanie Schwalm; Stefan Gauer; Dominique Thomas; Liliana Schaefer; Peter Boor; Alexander Koch; Josef Pfeilschifter
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.1 pp. 158821
- ISSN:
- 1388-1981
- Subject:
- biomarkers; blood serum; ceramides; cortex; diet; fibrosis; humans; kidneys; males; mice; neoplasms; pyelonephritis
- Abstract:
- ... Several studies revealed alterations of single sphingolipid species, such as chain length-specific ceramides, in plasma and serum of patients with kidney diseases. Here, we investigated whether such alterations occur in kidney tissue from patients and mice suffering from renal fibrosis, the common endpoint of chronic kidney diseases.Human fibrotic kidney samples were collected from nephrectomy spe ...
- DOI:
- 10.1016/j.bbalip.2020.158821
- https://doi.org/10.1016/j.bbalip.2020.158821
- Author:
- David García-Seisdedos; Bohdan Babiy; Milagros Lerma; María E. Casado; Javier Martínez-Botas; Miguel A. Lasunción; Óscar Pastor; Rebeca Busto
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.5 pp. 158638
- ISSN:
- 1388-1981
- Subject:
- Curcuma longa; animal models; ceramides; curcumin; enzyme inhibitors; exosomes; fumonisin B1; hydrophobicity; mice; neuroglia; polyphenols; rhizomes; secretion; serine C-palmitoyltransferase; sphingosine N-acyltransferase
- Abstract:
- ... Curcumin, a hydrophobic polyphenol found in the rhizome of Curcuma longa, has been shown to reduce intracellular lipid accumulation in mouse models of lysosomal storage diseases such as Niemann-Pick type C. Exosomes are small extracellular vesicles secreted by cells in response to changes in intracellular ceramide composition. Curcumin can induce exosome/microvesicle release in cellular models of ...
- DOI:
- 10.1016/j.bbalip.2020.158638
- https://doi.org/10.1016/j.bbalip.2020.158638
- Author:
- S. Rodriguez-Cuenca; N. Barbarroja; A. Vidal-Puig
- Source:
- Biochimica et biophysica acta 2015 v.1851 no.1 pp. 40-50
- ISSN:
- 1388-1981
- Subject:
- biosynthesis; ceramides; hypoxia; inflammation; lipotoxicity; oxidative stress
- Abstract:
- ... The pathogenic relevance of sphingolipid metabolism is increasingly being recognised. Here we elaborate on a new player within the sphingolipid field: the degs1 enzyme, a recently discovered enzyme that catalyses the final step in the de novo biosynthesis of ceramides controlling the step from dihydroceramides to ceramides. Here, we describe its function and dysregulation by factors such as oxidat ...
- DOI:
- 10.1016/j.bbalip.2014.09.021
- https://doi.org/10.1016/j.bbalip.2014.09.021
- Author:
- Mireia Casasampere; Yadira F. Ordóñez; Josefina Casas; Gemma Fabrias
- Source:
- Biochimica et biophysica acta 2017 v.1861 no.2 pp. 264-275
- ISSN:
- 0304-4165
- Subject:
- autophagy; cell viability; ceramides; cytotoxicity; death; drug therapy; drugs; lysosomes; mass spectrometry
- Abstract:
- ... Autophagy consists on the delivery of cytoplasmic material and organelles to lysosomes for degradation. Research on autophagy is a growing field because deciphering the basic mechanisms of autophagy is key to understanding its role in health and disease, and to paving the way to discovering novel therapeutic strategies. Studies with chemotherapeutic drugs and pharmacological tools support a role f ...
- DOI:
- 10.1016/j.bbagen.2016.11.033
- https://doi.org/10.1016/j.bbagen.2016.11.033
- Author:
- Barbora Janůšová; Jarmila Zbytovská; Petr Lorenc; Helena Vavrysová; Karel Palát; Alexandr Hrabálek; Kateřina Vávrová
- Source:
- Biochimica et biophysica acta 2011 v.1811 no.3 pp. 129-137
- ISSN:
- 1388-1981
- Subject:
- phase transition; temperature; theophylline; sphingosine; indomethacin; cholesterol; infrared spectroscopy; differential scanning calorimetry; cell membranes; hydrophobicity; hydrogen bonding; ceramides; structure-activity relationships; skin (animal); permeability
- Abstract:
- ... Stratum corneum ceramides play an essential role in the barrier properties of skin. However, their structure–activity relationships are poorly understood. We investigated the effects of acyl chain length in the non-hydroxy acyl sphingosine type (NS) ceramides on the skin permeability and their thermotropic phase behavior. Neither the long- to medium-chain ceramides (8–24C) nor free sphingosine pro ...
- DOI:
- 10.1016/j.bbalip.2010.12.003
- https://doi.org/10.1016/j.bbalip.2010.12.003
- Author:
- Zhiqiang Li; Yeun-Po Chiang; Mulin He; Ke Zhang; Jiao Zheng; Weihua Wu; Jiajia Cai; Yong Chen; Guangzhi Chen; Yunqin Chen; Jibin Dong; Tilla S. Worgall; Xian-Cheng Jiang
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.5 pp. 158898
- ISSN:
- 1388-1981
- Subject:
- biosynthesis; blood lipids; ceramides; gene targeting; high fat diet; lipoprotein metabolism; liver; low density lipoprotein; metabolites; phosphatidylcholines; sphingomyelins; triacylglycerols; very low density lipoprotein
- Abstract:
- ... Sphingomyelin (SM) is one major phospholipids on lipoproteins. It is enriched on apolipoprotein B-containing particles, including very low-density lipoprotein (VLDL) and its catabolites, low-density lipoprotein (LDL). SM is synthesized by sphingomyelin synthase 1 and 2 (SMS1 and SMS2) which utilizes ceramide and phosphatidylcholine, as two substrates, to produce SM and diacylglyceride. SMS1 and SM ...
- DOI:
- 10.1016/j.bbalip.2021.158898
- https://doi.org/10.1016/j.bbalip.2021.158898
- Author:
- Rebeca Busto; Jorge Serna; Aránzazu Perianes-Cachero; Rocío Quintana-Portillo; David García-Seisdedos; Alberto Canfrán-Duque; Carlos L. Paino; Milagros Lerma; María E. Casado; Antonia Martín-Hidalgo; Eduardo Arilla-Ferreiro; Miguel A. Lasunción; Óscar Pastor
- Source:
- Biochimica et biophysica acta 2018 v.1863 no.9 pp. 958-967
- ISSN:
- 1388-1981
- Subject:
- Mycobacterium tuberculosis; T-lymphocytes; adjuvants; biosynthesis; ceramides; cerebral cortex; cortex; drinking water; ellagic acid; encephalitis; guinea pigs; immunization; metabolites; models; myelin basic protein; myelin sheath; neuroprotective effect; polyphenols; rats; sclerosis; signs and symptoms (animals and humans); spinal cord; weight loss
- Abstract:
- ... Experimental autoimmune encephalomyelitis (EAE), the most common model for multiple sclerosis, is characterized by inflammatory cell infiltration into the central nervous system and demyelination. Previous studies have demonstrated that administration of some polyphenols may reduce the neurological alterations of EAE. In this work, we show that ellagic acid, a polyphenolic compound, is beneficial ...
- DOI:
- 10.1016/j.bbalip.2018.05.009
- https://doi.org/10.1016/j.bbalip.2018.05.009
- Author:
- Aline Bayerle; Christian Marsching; Mariona Rabionet; Shaalee Dworski; Mustafa A. Kamani; Chandramohan Chitraju; Nina L. Gluchowski; Katlyn R. Gabriel; Silke Herzer; Richard Jennemann; Thierry Levade; Jeffrey A. Medin; Roger Sandhoff
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.9 pp. 158741
- ISSN:
- 1388-1981
- Subject:
- brain; ceramide glucosyltransferase; ceramides; colon; diet; esterification; glucosylceramides; heart; kidneys; lipid metabolism; liver; lungs; lymph; mice; small intestine; spleen
- Abstract:
- ... Except for epidermis and liver, little is known about endogenous expression of 1-O-acylceramides (1-OACs) in mammalian tissue. Therefore, we screened several organs (brain, lung, liver, spleen, lymph nodes, heart, kidney, thymus, small intestine, and colon) from mice for the presence of 1-OACs by LC-MS². In most organs, low levels of about 0.25–1.3 pmol 1-OACs/mg wet weight were recorded. Higher l ...
- DOI:
- 10.1016/j.bbalip.2020.158741
- https://doi.org/10.1016/j.bbalip.2020.158741
- Author:
- Lucila G. Pescio; Nicolás O. Favale; María G. Márquez; Norma B. Sterin-Speziale
- Source:
- Biochimica et biophysica acta 2012 v.1821 no.6 pp. 884-894
- ISSN:
- 1388-1981
- Subject:
- cell differentiation; cell membranes; ceramides; cultured cells; dogs; epithelial cells; fumonisins; kidneys; small interfering RNA
- Abstract:
- ... Glycosphingolipids (GSLs), which are highly concentrated at the apical membrane of polarized epithelial cells, are key components of cell membranes and are involved in a large number of processes. Here, we investigated the ability of hypertonicity (high salt medium) to induce Madin–Darby Canine Kidney (MDCK) cell differentiation and found an increase in GSL synthesis under hypertonic conditions. T ...
- DOI:
- 10.1016/j.bbalip.2012.02.009
- https://doi.org/10.1016/j.bbalip.2012.02.009
- Author:
- Masayuki Sugimoto; Yoichi Shimizu; Takeshi Yoshioka; Masato Wakabayashi; Yukari Tanaka; Kenichi Higashino; Yoshito Numata; Shota Sakai; Akio Kihara; Yasuyuki Igarashi; Yuji Kuge
- Source:
- Biochimica et biophysica acta 2015 v.1851 no.12 pp. 1554-1565
- ISSN:
- 1388-1981
- Subject:
- brain; ceramides; gene expression; human cell lines; image analysis; in situ hybridization; mass spectrometry; messenger RNA; mice; signal transduction; small interfering RNA; sphingomyelins; sphingosine N-acyltransferase; substrate specificity; very long chain fatty acids
- Abstract:
- ... Sphingomyelin (SM) is synthesized by SM synthase (SMS) from ceramide (Cer). SM regulates signaling pathways and maintains organ structure. SM comprises a sphingoid base and differing lengths of acyl-chains, but the importance of its various forms and regulatory synthases is not known. It has been reported that Cer synthase (CerS) has restricted substrate specificity, whereas SMS has no specificity ...
- DOI:
- 10.1016/j.bbalip.2015.09.004
- https://doi.org/10.1016/j.bbalip.2015.09.004
- Author:
- Maria A. Ahonen; Muhammad Yasir Asghar; Suvi J. Parviainen; Gerhard Liebisch; Marcus Höring; Marjut Leidenius; Pamela Fischer-Posovszky; Martin Wabitsch; Tomi S. Mikkola; Kid Törnquist; Hanna Savolainen-Peltonen; P.A. Nidhina Haridas; Vesa M. Olkkonen
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.1 pp. 158841
- ISSN:
- 1388-1981
- Subject:
- ATP citrate synthase; adipocytes; adipose tissue; breast neoplasms; ceramides; diacylglycerols; humans; lipogenesis; neoplasm progression; sphingomyelins; triacylglycerols
- Abstract:
- ... MicroRNA-221-3p (miR-221-3p) is associated with both metabolic diseases and cancers. However, its role in terminal adipocyte differentiation and lipid metabolism are uncharacterized. miR-221-3p or its inhibitor was transfected into differentiating or mature human adipocytes. Triglyceride (TG) content and adipogenic gene expression were monitored, global lipidome analysis was carried out, and mecha ...
- DOI:
- 10.1016/j.bbalip.2020.158841
- https://doi.org/10.1016/j.bbalip.2020.158841
- Author:
- Renata Martins Cardoso; Eline Creemers; Samira Absalah; Menno Hoekstra; Gert S. Gooris; Joke A. Bouwstra; Miranda Van Eck
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.3 pp. 158592
- ISSN:
- 1388-1981
- Subject:
- apolipoprotein B; benzoic acids; ceramides; cholesteremic effect; cholesteryl esters; free fatty acids; gene expression regulation; genes; high density lipoprotein cholesterol; hypercholesterolemia; knockout mutants; lipid composition; mice; permeability
- Abstract:
- ... Scavenger receptor class B type I (SR-BI) mediates the selective uptake of cholesteryl esters (CE) from high-density lipoproteins (HDL). An impaired SR-BI function leads to hyperalphalipoproteinemia with elevated levels of cholesterol transported in the HDL fraction. Accumulation of cholesterol in apolipoprotein B (apoB)-containing lipoproteins has been shown to alter skin lipid composition and ba ...
- DOI:
- 10.1016/j.bbalip.2019.158592
- https://doi.org/10.1016/j.bbalip.2019.158592
- Author:
- Richard W.J. Helder; Jannik Rousel; Walter A. Boiten; Gerrit S. Gooris; Andreea Nadaban; Abdoelwaheb El Ghalbzouri; Joke A. Bouwstra
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.4 pp. 158885
- ISSN:
- 1388-1981
- Subject:
- ceramides; homeostasis; lipid content; models; stearoyl-CoA desaturase
- Abstract:
- ... Full thickness models (FTM) are 3D in vitro skin cultures that resemble the native human skin (NHS) to a great extent. However, the barrier function of these skin models is reduced. The skin barrier is located in the stratum corneum (SC) and consists of corneocytes embedded in a lipid matrix. In this matrix, deviations in the composition of the FTMs lipid matrix may contribute to the impaired skin ...
- DOI:
- 10.1016/j.bbalip.2021.158885
- https://doi.org/10.1016/j.bbalip.2021.158885
- Author:
- Andreas Bickert; Paul Kern; Martina van Uelft; Stefanie Herresthal; Thomas Ulas; Katharina Gutbrod; Bernadette Breiden; Joachim Degen; Konrad Sandhoff; Joachim L. Schultze; Peter Dörmann; Dieter Hartmann; Reinhard Bauer; Klaus Willecke
- Source:
- Biochimica et biophysica acta 2018 v.1863 no.7 pp. 734-749
- ISSN:
- 1388-1981
- Subject:
- alanine; catalytic activity; cell division; ceramides; genes; histidine; lipid metabolism; liver; messenger RNA; mice; mutants; protein content; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; sphingosine N-acyltransferase; transcription (genetics); transgenic animals
- Abstract:
- ... The replacement of two consecutive histidine residues by alanine residues in the catalytic center of ceramide synthase 2 in a new transgenic mouse mutant (CerS2 H/A) leads to inactivation of catalytic activity and reduces protein level to 60% of the WT level. We show here by qRT-PCR and transcriptome analyses that several transcripts of genes involved in lipid metabolism and cell division are diff ...
- DOI:
- 10.1016/j.bbalip.2018.04.006
- https://doi.org/10.1016/j.bbalip.2018.04.006
- Author:
- Anna Caretti; Riccardo Torelli; Federica Perdoni; Monica Falleni; Delfina Tosi; Aida Zulueta; Josefina Casas; Maurizio Sanguinetti; Riccardo Ghidoni; Elisa Borghi; Paola Signorelli
- Source:
- Biochimica et biophysica acta 2016 v.1860 no.6 pp. 1089-1097
- ISSN:
- 0304-4165
- Subject:
- Aspergillus fumigatus; antifungal agents; antifungal properties; asthma; ceramides; conidia; cystic fibrosis; epithelial cells; epithelium; fungi; immunity; inflammation; intracellular signaling peptides and proteins; lungs; mice; nanocarriers; pathogens; patients
- Abstract:
- ... Fungal infections develop in pulmonary chronic inflammatory diseases such as asthma, Chronic Obstructive Pulmonary Disease (COPD) and Cystic Fibrosis (CF). The available antifungal drugs may fail to eradicate fungal pathogens, that can invade the lungs and vessels and spread by systemic circulation taking advantage of defective lung immunity. An increased rate of sphingolipid de novo synthesis, le ...
- DOI:
- 10.1016/j.bbagen.2016.02.014
- https://doi.org/10.1016/j.bbagen.2016.02.014
- Author:
- Satoshi Tomizawa; Mizuki Tamori; Ai Tanaka; Naoya Utsumi; Hiromi Sato; Hiroto Hatakeyama; Akihiro Hisaka; Takafumi Kohama; Kazuyuki Yamagata; Takuya Honda; Hiroyuki Nakamura; Toshihiko Murayama
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.6 pp. 158675
- ISSN:
- 1388-1981
- Subject:
- breast neoplasms; cell movement; ceramides; enzymes; epidermal growth factor; fibroblasts; intravenous injection; lung neoplasms; lungs; metastasis; mice; neoplasm cells; pseudopodia
- Abstract:
- ... Ceramide kinase (CerK) phosphorylates ceramide to ceramide-1-phosphate (C1P), a bioactive sphingolipid. Since the mechanisms responsible for regulating the proliferation and migration/metastasis of cancer cells by the CerK/C1P pathway remain unclear, we conducted the present study. The knockdown of CerK in A549 lung and MCF-7 breast cancer cells (shCerK cells) increased the formation of lamellipod ...
- DOI:
- 10.1016/j.bbalip.2020.158675
- https://doi.org/10.1016/j.bbalip.2020.158675
- Author:
- Y.Y. Lam; G. Hatzinikolas; J.M. Weir; A. Janovská; A.J. McAinch; P. Game; P.J. Meikle; G.A. Wittert
- Source:
- Biochimica et biophysica acta 2011 v.1811 no.7-8 pp. 468-475
- ISSN:
- 1388-1981
- Subject:
- IKappaB kinase; adipose tissue; ceramides; docosahexaenoic acid; energy metabolism; gene expression; genes; glucose; humans; insulin resistance; linoleic acid; lipid content; lipid metabolism; messenger RNA; myotubes; nutrient utilization; omega-6 fatty acids; palmitic acid; protein synthesis; skeletal muscle; transcription (genetics); transcription factor NF-kappa B; visceral fat
- Abstract:
- ... Aims. The study aims to determine the effect of long-chain saturated and polyunsaturated (PUFA) fatty acids, specifically palmitic acid (PA; 16:0), docosahexaenoic acid (DHA; 22:6n-3) and linoleic acid (LA; 18:2n-6), and their interactions with factors from adipose tissue, on insulin sensitivity and lipid metabolism in skeletal muscle. Methods. L6 myotubes were cultured with PA, DHA or LA (0.4mmol ...
- DOI:
- 10.1016/j.bbalip.2011.04.011
- https://doi.org/10.1016/j.bbalip.2011.04.011
- Author:
- Monilola A. Olayioye; Angelika Hausser
- Source:
- Biochimica et biophysica acta 2012 v.1821 no.8 pp. 1096-1103
- ISSN:
- 1388-1981
- Subject:
- Golgi apparatus; ceramides; endoplasmic reticulum; homeostasis; lipid composition
- Abstract:
- ... Non-vesicular transport of ceramide from endoplasmic reticulum to Golgi membranes is essential for cellular lipid homeostasis. Protein kinase D (PKD) is a serine–threonine kinase that controls vesicle fission at Golgi membranes. Here we highlight the intimate connections between non-vesicular and vesicular transport at the level of the Golgi complex, and suggest that PKD and its substrate CERT, th ...
- DOI:
- 10.1016/j.bbalip.2011.12.005
- https://doi.org/10.1016/j.bbalip.2011.12.005
- Author:
- Kazuhito Tsuboi; Tatsuya Tai; Ryouhei Yamashita; Hanif Ali; Takashi Watanabe; Toru Uyama; Yoko Okamoto; Keisuke Kitakaze; Yasuhiro Takenouchi; Shinji Go; Iffat Ara Sonia Rahman; Hitoshi Houchi; Tamotsu Tanaka; Yasuo Okamoto; Akira Tokumura; Junko Matsuda; Natsuo Ueda
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.9 pp. 158972
- ISSN:
- 1388-1981
- Subject:
- amidase; ceramides; ethanolamine; fatty acids; humans; liquid chromatography; tandem mass spectrometry
- Abstract:
- ... Bioactive N-acylethanolamines (NAEs) include palmitoylethanolamide, oleoylethanolamide, and anandamide, which exert anti-inflammatory, anorexic, and cannabimimetic actions, respectively. The degradation of NAEs has been attributed to two hydrolases, fatty acid amide hydrolase and NAE acid amidase (NAAA). Acid ceramidase (AC) is a lysosomal enzyme that hydrolyzes ceramide (N-acylsphingosine), which ...
- DOI:
- 10.1016/j.bbalip.2021.158972
- https://doi.org/10.1016/j.bbalip.2021.158972
- Author:
- Andrea Dichlberger; Kecheng Zhou; Nils Bäck; Thomas Nyholm; Anders Backman; Peter Mattjus; Elina Ikonen; Tomas Blom
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.2 pp. 158855
- ISSN:
- 1388-1981
- Subject:
- cell culture; ceramides; culture media; endosomes; humans; lipid composition; lipidomics; lysosomes; mutants; urine
- Abstract:
- ... Lysosome Associated Protein Transmembrane 4B (LAPTM4B) is a four-membrane spanning ceramide interacting protein that regulates mTORC1 signaling. Here, we show that LAPTM4B is sorted into intraluminal vesicles (ILVs) of multivesicular endosomes (MVEs) and released in small extracellular vesicles (sEVs) into conditioned cell culture medium and human urine. Efficient sorting of LAPTM4B into ILV membr ...
- DOI:
- 10.1016/j.bbalip.2020.158855
- https://doi.org/10.1016/j.bbalip.2020.158855
- Author:
- Felipe Macedo; Gabriel Loureiro Martins; Luis A. Luévano-Martínez; Gustavo Monteiro Viana; Karin A. Riske; Alex Inague; Marcos Y. Yoshinaga; Hugo Aguilaniu; Sayuri Miyamoto; Isaias Glezer; Fernanda Marques da Cunha
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.2 pp. 158539
- ISSN:
- 1388-1981
- Subject:
- Caenorhabditis elegans; carboxylic ester hydrolases; cardiolipins; ceramides; fatty acids; food deprivation; gastric acid; genes; humans; lipid composition; mitochondria; mutants; starvation
- Abstract:
- ... The C. elegans lipase-like 5 (lipl-5) gene is predicted to code for a lipase homologous to the human gastric acid lipase. Its expression was previously shown to be modulated by nutritional or immune cues, but nothing is known about its impact on the lipid landscape and ensuing functional consequences. In the present work, we used mutants lacking LIPL-5 protein and found that lipl-5 is important fo ...
- DOI:
- 10.1016/j.bbalip.2019.158539
- https://doi.org/10.1016/j.bbalip.2019.158539
- Author:
- Tianci Jiang; Lingling Dai; Pengfei Li; Junwei Zhao; Xi Wang; Lin An; Meng Liu; Shujun Wu; Yu Wang; Youmei Peng; Di Sun; Caopei Zheng; Tingting Wang; Xuejun Wen; Zhe Cheng
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.2 pp. 158853
- ISSN:
- 1388-1981
- Subject:
- asthma; biomarkers; blood lipids; ceramides; energy; lipid composition; lipid metabolism; lipidomics; liquid chromatography; lysophosphatidylcholine; mass spectrometry; metabolites; phosphatidylethanolamines; signal transduction; sphingomyelins; triacylglycerols
- Abstract:
- ... Lipids participate in many important biological functions through energy storage, material transport, signal transduction, and molecular recognition processes. Studies have reported that asthmatic patients have abnormal lipid metabolism. However, there are limited studies on the characterization of lipid metabolism in asthmatic patients by lipidomics.We characterized the plasma lipid profile of 28 ...
- DOI:
- 10.1016/j.bbalip.2020.158853
- https://doi.org/10.1016/j.bbalip.2020.158853
- Author:
- Kenneth D'Souza; Carine Nzirorera; Petra C. Kienesberger
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.10 pp. 1513-1524
- ISSN:
- 1388-1981
- Subject:
- adenosine triphosphate; beta oxidation; biosynthesis; cardiomyocytes; cardiomyopathy; ceramides; diabetes; diacylglycerols; droplets; enzymes; lipotoxicity; metabolites; mice; mutants; obesity; oxidation; phospholipids; signal transduction; toxicity; triacylglycerols
- Abstract:
- ... The heart balances uptake, metabolism and oxidation of fatty acids (FAs) to maintain ATP production, membrane biosynthesis and lipid signaling. Under conditions where FA uptake outpaces FA oxidation and FA sequestration as triacylglycerols in lipid droplets, toxic FA metabolites such as ceramides, diacylglycerols, long-chain acyl-CoAs, and acylcarnitines can accumulate in cardiomyocytes and cause ...
- DOI:
- 10.1016/j.bbalip.2016.02.016
- https://doi.org/10.1016/j.bbalip.2016.02.016
- Author:
- Stephen C. Kolwicz
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.10 pp. 1472-1480
- ISSN:
- 1388-1981
- Subject:
- beta oxidation; biosynthesis; ceramides; diacylglycerols; exercise; fatty acids; fuels; heart failure; hypertrophy; models; myocardium; oxidation; phospholipids; triacylglycerols
- Abstract:
- ... It is well documented that fatty acids serve as the primary fuel substrate for the contracting myocardium. However, extensive research has identified significant changes in the myocardial oxidation of fatty acids during acute or chronic cardiac stress. As a result, the redistribution or partitioning of fatty acids due to metabolic derangements could have biological implications. Fatty acids can be ...
- DOI:
- 10.1016/j.bbalip.2016.03.028
- https://doi.org/10.1016/j.bbalip.2016.03.028
- Author:
- Romain Magny; Karima Kessal; Anne Regazzetti; Asma Ben Yedder; Christophe Baudouin; Stéphane Mélik Parsadaniantz; Françoise Brignole-Baudouin; Olivier Laprévote; Nicolas Auzeil
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.9 pp. 158728
- ISSN:
- 1388-1981
- Subject:
- ammonium salts; benzalkonium chloride; biomarkers; ceramides; cornea; droplets; epithelium; eye diseases; glycerophospholipids; humans; inflammation; lipid metabolism; lipidomics; lysophospholipids; quaternary ammonium compounds; therapeutics; triacylglycerols
- Abstract:
- ... Dry eye disease (DED) is a multifactorial chronic inflammatory disease of the ocular surface characterized by tear film instability, hyperosmolarity, cell damage and inflammation. Hyperosmolarity is strongly established as the core mechanism of the DED. Benzalkonium chloride (BAK) - a quaternary ammonium salt commonly used in eye drops for its microbicidal properties - is well known to favor the o ...
- DOI:
- 10.1016/j.bbalip.2020.158728
- https://doi.org/10.1016/j.bbalip.2020.158728
- Author:
- Meike Siebers; Mathias Brands; Vera Wewer; Yanjiao Duan; Georg Hölzl; Peter Dörmann
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.9 pp. 1379-1395
- ISSN:
- 1388-1981
- Subject:
- bacteria; ceramides; diacylglycerols; free fatty acids; fungi; jasmonic acid; oxylipins; phospholipids; systemic acquired resistance
- Abstract:
- ... Bacteria and fungi can undergo symbiotic or pathogenic interactions with plants. Membrane lipids and lipid-derived molecules from the plant or the microbial organism play important roles during the infection process. For example, lipids (phospholipids, glycolipids, sphingolipids, sterol lipids) are involved in establishing the membrane interface between the two organisms. Furthermore, lipid-derive ...
- DOI:
- 10.1016/j.bbalip.2016.02.021
- https://doi.org/10.1016/j.bbalip.2016.02.021
- Author:
- Igor Zlobine; Keshav Gopal; John R. Ussher
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.10 pp. 1555-1568
- ISSN:
- 1388-1981
- Subject:
- acyl coenzyme A; animal models; beta oxidation; cardiomyopathy; ceramides; coronary artery disease; diacylglycerols; fatty acids; heart; humans; hypertension; lipotoxicity; noninsulin-dependent diabetes mellitus; obesity; pathophysiology; patients; risk; toxicity; triacylglycerols
- Abstract:
- ... Patients with type 2 diabetes (T2D) are at increased risk for cardiovascular diseases including diabetic cardiomyopathy, which is ventricular dysfunction independent of underlying coronary artery disease and/or hypertension. With numerous advancements in our ability to detect ventricular dysfunction, as well as the molecular mechanisms contributing to ventricular dysfunction in diabetic patients, ...
- DOI:
- 10.1016/j.bbalip.2016.02.011
- https://doi.org/10.1016/j.bbalip.2016.02.011
- Author:
- Hany Farwanah; Thomas Kolter; Konrad Sandhoff
- Source:
- Biochimica et biophysica acta 2011 v.1811 no.11 pp. 854-860
- ISSN:
- 1388-1981
- Subject:
- ceramides; cholesterol; image analysis; lipid metabolism; mass spectrometry; sphingomyelins
- Abstract:
- ... Sphingolipids represent an important class among lipids, especially when considering their vital roles in lipid metabolism. Thus, a variety of methods have been created to accomplish their analysis and the term “sphingolipidomics” has recently been coined to underline the motivation to enable a comprehensive analysis of all sphingolipid species including the acidic and the neutral ones. In this re ...
- DOI:
- 10.1016/j.bbalip.2011.05.011
- https://doi.org/10.1016/j.bbalip.2011.05.011
- Author:
- Lian-Ying Wu; Thomas De Luca; Takahiro Watanabe; Dorothy M. Morré; D. James Morré
- Source:
- Biochimica et biophysica acta 2011 v.1810 no.8 pp. 784-789
- ISSN:
- 0304-4165
- Subject:
- 4',6-diamidino-2-phenylindole; NAD (coenzyme); apoptosis; catechin; ceramides; dose response; fluorescence; green tea; growth retardation; isoflavones; metabolic inhibitors; metabolism; metabolites; plasma membrane; sphingosine
- Abstract:
- ... BACKGROUND: Constituents and inhibitors of intermediary metabolism resulting in alterations in levels of cytosolic NADH, stimulation of sphingomyelinase and inhibition of sphingosine kinase were evaluated for effects on growth inhibition and induction of apoptosis by the ENOX2 inhibitors EGCG, the principal catechin of green tea, and phenoxodiol, a naturally occurring isoflavone. METHODS: Response ...
- DOI:
- 10.1016/j.bbagen.2011.04.011
- https://doi.org/10.1016/j.bbagen.2011.04.011
- Author:
- Ian A. Trounce; Peter J. Crouch; Kirstyn T. Carey; Matthew McKenzie
- Source:
- Biochimica et biophysica acta 2013 v.1827 no.7 pp. 817-825
- ISSN:
- 0005-2728
- Subject:
- Rattus norvegicus; binding sites; biogenesis; cell death; ceramides; cytochrome b; fibroblasts; mice; mitochondria; mitochondrial DNA; mutation; oxidative phosphorylation; reactive oxygen species; ubiquinones
- Abstract:
- ... Mitochondria play an integral role in cell death signaling, yet how mitochondrial defects disrupt this important function is not well understood. We have used a mouse L-cell fibroblast model harboring Rattus norvegicus mtDNA (Rn xenocybrids) to examine the effects of multiple oxidative phosphorylation (OXPHOS) defects on reactive oxygen species (ROS) generation and cell death signaling. Blue nativ ...
- DOI:
- 10.1016/j.bbabio.2013.03.012
- https://doi.org/10.1016/j.bbabio.2013.03.012
- Author:
- Frédérique Sabourdy; Leonardo Astudillo; Céline Colacios; Patricia Dubot; Marguerite Mrad; Bruno Ségui; Nathalie Andrieu-Abadie; Thierry Levade
- Source:
- Biochimica et biophysica acta 2015 v.1851 no.8 pp. 1040-1051
- ISSN:
- 1388-1981
- Subject:
- brain; ceramides; enzyme deficiencies; enzymes; gene targeting; genes; humans; metabolism; mice; mutation; nervous system diseases; neurons
- Abstract:
- ... Sphingolipids comprise a wide variety of molecules containing a sphingoid long-chain base that can be N-acylated. These lipids are particularly abundant in the central nervous system, being membrane components of neurons as well as non-neuronal cells. Direct evidence that these brain lipids play critical functions in brain physiology is illustrated by the dramatic consequences of genetic disturban ...
- DOI:
- 10.1016/j.bbalip.2015.01.010
- https://doi.org/10.1016/j.bbalip.2015.01.010
- Author:
- Natalia Presa; Ana Gomez-Larrauri; Asier Dominguez-Herrera; Miguel Trueba; Antonio Gomez-Muñoz
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.4 pp. 158630
- ISSN:
- 1388-1981
- Subject:
- adipocytes; adipogenesis; adipose tissue; anti-inflammatory activity; apoptosis; arachidonic acid; cell growth; cell movement; cell viability; ceramides; fibroblasts; inflammation; interleukin-10; lungs; macrophages; mammals; monocytes; neoplasms; phospholipase A2; phospholipases; pulmonary emphysema; transcription factor NF-kappa B
- Abstract:
- ... The bioactive sphingolipid ceramide 1-phosphate (C1P) regulates key physiologic cell functions and is implicated in a number of metabolic alterations and pathological processes. Initial studies using different types of fibroblasts and monocytes/macrophages revealed that C1P was mitogenic and that it promoted cell survival through inhibition of apoptosis. Subsequent studies implicated C1P in inflam ...
- DOI:
- 10.1016/j.bbalip.2020.158630
- https://doi.org/10.1016/j.bbalip.2020.158630
- Author:
- Hisako Akiyama; Narie Sasaki; Shuwa Hanazawa; Mari Gotoh; Susumu Kobayashi; Yoshio Hirabayashi; Kimiko Murakami-Murofushi
- Source:
- Biochimica et biophysica acta 2011 v.1811 no.5 pp. 314-322
- ISSN:
- 1388-1981
- Subject:
- ceramides; cholesterol; cultured cells; fibroblasts; fungi; glucose; heat production; heat shock response; heat-shock protein 70; humans; mass spectrometry; melanoma; mutants; stomach; substrate specificity; swine; transcription factors; uridine diphosphate
- Abstract:
- ... Cholesteryl glucoside (CG), a membrane glycolipid, regulates heat shock response. CG is rapidly induced by heat shock before the activation of heat shock transcription factor 1 (HSF1) and production of heat shock protein 70 (HSP70), and the addition of CG in turn induces HSF1 activation and HSP70 production in human fibroblasts; thus, a reasonable correlation is that CG functions as a crucial lipi ...
- DOI:
- 10.1016/j.bbalip.2011.02.005
- https://doi.org/10.1016/j.bbalip.2011.02.005
- Author:
- Alexandre Pinel; Jean-Paul Rigaudière; Brigitte Laillet; Corinne Pouyet; Corinne Malpuech-Brugère; Carina Prip-Buus; Béatrice Morio; Frédéric Capel
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.1 pp. 12-20
- ISSN:
- 1388-1981
- Subject:
- alpha-linolenic acid; beta oxidation; ceramides; diacylglycerols; docosahexaenoic acid; eicosapentaenoic acid; energy intake; fatty acid metabolism; glucose; insulin resistance; lipotoxicity; mitochondria; myotubes; omega-3 fatty acids; palmitates; saturated fatty acids; skeletal muscle
- Abstract:
- ... Excessive energy intake leads to fat overload and the formation of lipotoxic compounds mainly derived from the saturated fatty acid palmitate (PAL), thus promoting insulin resistance (IR) in skeletal muscle. N−3 polyunsaturated fatty acids (n−3PUFA) may prevent lipotoxicity and IR. The purpose of this study was to examine the differential effects of n−3PUFA on fatty acid metabolism and insulin sen ...
- DOI:
- 10.1016/j.bbalip.2015.10.003
- https://doi.org/10.1016/j.bbalip.2015.10.003
- Author:
- Frédéric Capel; Naoufel Cheraiti; Cécile Acquaviva; Carole Hénique; Justine Bertrand-Michel; Christine Vianey-Saban; Carina Prip-Buus; Béatrice Morio
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.12 pp. 2000-2010
- ISSN:
- 1388-1981
- Subject:
- beta oxidation; carbon dioxide; ceramides; diacylglycerols; insulin; insulin resistance; mitochondria; mitogen-activated protein kinase; muscles; myotubes; oleic acid; oxidation; palmitates; phosphorylation; protective effect; protein kinase C; radiolabeling; signal transduction; skeletal muscle; triacylglycerols
- Abstract:
- ... Because the protective effect of oleate against palmitate-induced insulin resistance may be lessened in skeletal muscle once cell metabolism is overloaded by fatty acids (FAs), we examined the impact of varying amounts of oleate on palmitate metabolic channeling and insulin signaling in C2C12 myotubes. Cells were exposed to 0.5mM of palmitate and to increasing doses of oleate (0.05, 0.25 and 0.5mM ...
- DOI:
- 10.1016/j.bbalip.2016.10.002
- https://doi.org/10.1016/j.bbalip.2016.10.002
- Author:
- Elodie Lafont; Romain Dupont; Nathalie Andrieu-Abadie; Toshiro Okazaki; Klaus Schulze-Osthoff; Thierry Levade; Hervé Benoist; Bruno Ségui
- Source:
- Biochimica et biophysica acta 2012 v.1821 no.4 pp. 684-693
- ISSN:
- 1388-1981
- Subject:
- T-lymphocytes; apoptosis; caspase-3; caspase-8; caspase-9; ceramides; cytochrome c; leukemia; mitochondria; sphingomyelins
- Abstract:
- ... Ceramide, a biologically active sphingolipid in cell death signaling, accumulates upon CD95L treatment, concomitantly to apoptosis induction in Jurkat leukemia T cells. Herein, we show that ceramide did not increase in caspase-8 and -10-doubly deficient Jurkat cells in response to CD95L, indicating that apical caspases are essential for CD95L-triggered ceramide formation. Jurkat cells are typicall ...
- DOI:
- 10.1016/j.bbalip.2012.01.012
- https://doi.org/10.1016/j.bbalip.2012.01.012
- Author:
- Greg M. Kowalski; Joachim Kloehn; Micah L. Burch; Ahrathy Selathurai; Steven Hamley; Stéphanie A.M. Bayol; Séverine Lamon; Matthew J. Watt; Robert S. Lee-Young; Malcolm J. McConville; Clinton R. Bruce
- Source:
- Biochimica et biophysica acta 2015 v.1851 no.2 pp. 210-219
- ISSN:
- 1388-1981
- Subject:
- ceramides; diacylglycerols; enzymes; gluconeogenesis; glucose; glucose tolerance; glucose tolerance tests; glycogenolysis; high fat diet; insulin resistance; liver; low fat diet; mice; noninsulin-dependent diabetes mellitus; risk factors; sphingosine; triacylglycerols
- Abstract:
- ... Hepatic insulin resistance is a major risk factor for the development of type 2 diabetes and is associated with the accumulation of lipids, including diacylglycerol (DAG), triacylglycerols (TAG) and ceramide. There is evidence that enzymes involved in ceramide or sphingolipid metabolism may have a role in regulating concentrations of glycerolipids such as DAG and TAG. Here we have investigated the ...
- DOI:
- 10.1016/j.bbalip.2014.12.002
- https://doi.org/10.1016/j.bbalip.2014.12.002
- Author:
- Jessica Seeßle; Gerhard Liebisch; Gerd Schmitz; Wolfgang Stremmel; Walee Chamulitrat
- Source:
- Biochimica et biophysica acta 2015 v.1851 no.5 pp. 549-565
- ISSN:
- 1388-1981
- Subject:
- acyl coenzyme A; acylation; apoptosis; ceramides; cytoskeleton; endoplasmic reticulum; fatty acid composition; fatty acids; fatty liver; insulin resistance; ligases; lipid metabolism; liver; lysophosphatidylcholine; mitochondria; mitogen-activated protein kinase; palmitates; phosphatidylethanolamines; sphingosine N-acyltransferase; transport proteins; triacylglycerols
- Abstract:
- ... Fatty acid transport protein (FATP) 4 is a minor FATP in the liver but it has some activity towards palmitate 16:0 (Pal). We here chose FATP4 as a representative model enzyme for acyl-CoA synthetases (ACSs), and FATPs to determine whether Pal activation would lead to apoptosis and alteration in lipid metabolism. By using FATP4 overexpressed (FATP4) Huh-7 cells, we showed that FATP4 was localized i ...
- DOI:
- 10.1016/j.bbalip.2015.01.004
- https://doi.org/10.1016/j.bbalip.2015.01.004
- Author:
- Sara Ghezzal; Barbara Graziela Postal; Elodie Quevrain; Loic Brot; Philippe Seksik; Armelle Leturque; Sophie Thenet; Véronique Carrière
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.2 pp. 158530
- ISSN:
- 1388-1981
- Subject:
- Clostridium leptum; bacteria; ceramides; cytokines; epithelium; humans; inflammation; intestines; metabolic diseases; mice; obesity; oleic acid; palm oils; palmitic acid; permeability; proteins
- Abstract:
- ... The mechanisms leading to the low-grade inflammation observed during obesity are not fully understood. Seeking the initiating events, we tested the hypothesis that the intestine could be damaged by repeated lipid supply and therefore participate in inflammation. In mice, 1–5 palm oil gavages increased intestinal permeability via decreased expression and mislocalization of junctional proteins at th ...
- DOI:
- 10.1016/j.bbalip.2019.158530
- https://doi.org/10.1016/j.bbalip.2019.158530
- Author:
- Lorissa J. Niebergall; René L. Jacobs; Todd Chaba; Dennis E. Vance
- Source:
- Biochimica et biophysica acta 2011 v.1811 no.12 pp. 1177-1185
- ISSN:
- 1388-1981
- Subject:
- Adenoviridae; betaine; biosynthesis; ceramides; fatty liver; high fat diet; liver; mice; pathogenesis; phosphatidylcholines; secretion; triacylglycerols; very low density lipoprotein
- Abstract:
- ... Several studies suggest that low levels of hepatic phosphatidylcholine (PC) play a role in the pathogenesis of non-alcoholic steatohepatitis (NASH). CTP: phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-choline pathway for PC biosynthesis. Liver-specific elimination of CTα (LCTα⁻/⁻) in mice fed a chow diet decreases very-low-density lipoprotein secretion, reduces li ...
- DOI:
- 10.1016/j.bbalip.2011.06.021
- https://doi.org/10.1016/j.bbalip.2011.06.021
- Author:
- Honoka Tanno; Takayuki Sassa; Megumi Sawai; Akio Kihara
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.1 pp. 158842
- ISSN:
- 1388-1981
- Subject:
- ceramides; eyes; fatty acid elongase; isozymes; liquid chromatography; liver; mice; mutants; tandem mass spectrometry; tissue distribution
- Abstract:
- ... Although most mammalian fatty acids (FAs) are straight-chain, there also exist branched-chain FAs such as iso- and anteiso-FAs, especially in the meibomian glands. Meibum lipids, which are secreted from the meibomian glands and are important for dry eye prevention, contain abundant branched-chain lipids, such as cholesteryl esters and wax esters with chain-lengths of ≥C21 (very-long-chain; VLC). H ...
- DOI:
- 10.1016/j.bbalip.2020.158842
- https://doi.org/10.1016/j.bbalip.2020.158842
- Author:
- Faisal Thayyullathil; Shahanas Chathoth; Abdulkader Hago; Mahendra Patel; Zdzislaw M. Szulc; Yusuf Hannun; Sehamuddin Galadari
- Source:
- Biochimica et biophysica acta 2011 v.1811 no.4 pp. 242-252
- ISSN:
- 1388-1981
- Subject:
- EDTA (chelating agent); brain; calcium; ceramides; enzyme activity; enzymes; free fatty acids; hydrolysis; hydrophobicity; iron; manganese; mercury; metal ions; molecular weight; octoxynol; polyacrylamide gel electrophoresis; rats; sphingosine; uridine monophosphate
- Abstract:
- ... Ceramidases (CDase) are enzymes that catalyze the hydrolysis of N-acyl linkage of ceramide (Cer) to generate sphingosine and free fatty acids. In this study we report the purification and characterization of a novel second type of neutral ceramidase from rat brain (RBCDase II). Triton X-100 protein extract from rat brain membrane was purified sequentially using Q-Sepharose, HiLoad16/60 Superdex 20 ...
- DOI:
- 10.1016/j.bbalip.2010.12.012
- https://doi.org/10.1016/j.bbalip.2010.12.012
- Author:
- Walter Boiten; Samira Absalah; Rob Vreeken; Joke Bouwstra; Jeroen van Smeden
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.11 pp. 1652-1661
- ISSN:
- 1388-1981
- Subject:
- carbon; ceramides; harvesting; humans; models; quantitative analysis; sphingosine
- Abstract:
- ... In the outermost layer of the skin, the stratum corneum (SC), ceramides form a diverse and essential pool of lipids. Due to their diversity and the limited availability of synthetic standards it is challenging to quantitatively analyse all SC ceramides independently. We aim to perform a detailed analysis of ceramides on SC harvested from in vivo and ex vivo skin, therefore, a LC/MS method was deve ...
- DOI:
- 10.1016/j.bbalip.2016.07.004
- https://doi.org/10.1016/j.bbalip.2016.07.004
- Author:
- Natalia Presa; Ana Gomez-Larrauri; Io-Guané Rivera; Marta Ordoñez; Miguel Trueba; Antonio Gomez-Muñoz
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.5 pp. 402-409
- ISSN:
- 1388-1981
- Subject:
- anti-inflammatory activity; arachidonic acid; biosynthesis; cell death; cell growth; cell movement; ceramides; cytokines; inflammation; metabolites; phospholipase A2; prostaglandins; pulmonary emphysema; tissues; transcription factor NF-kappa B
- Abstract:
- ... Ceramide 1-phosphate (C1P) is a bioactive sphingolipid metabolite first shown to regulate cell growth and death. Subsequent studies revealed that C1P was a potent stimulator of cytosolic phospholipase A2 (cPLA2) with ensuing release of arachidonic acid and prostaglandin biosynthesis. The latter findings placed C1P on the list of pro-inflammatory metabolites. More recently, C1P was found to potentl ...
- DOI:
- 10.1016/j.bbalip.2016.02.007
- https://doi.org/10.1016/j.bbalip.2016.02.007
- Author:
- Magdalene K. Montgomery; Simon H.J. Brown; Xin Y. Lim; Corrine E. Fiveash; Brenna Osborne; Nicholas L. Bentley; Jeremy P. Braude; Todd W. Mitchell; Adelle C.F. Coster; Anthony S. Don; Gregory J. Cooney; Carsten Schmitz-Peiffer; Nigel Turner
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.11 pp. 1828-1839
- ISSN:
- 1388-1981
- Subject:
- acylation; ceramides; glucose; glucose tolerance; hepatocytes; homeostasis; insulin; insulin resistance; liver; mice; protective effect; protein content; signal transduction; sphingomyelins; sphingosine N-acyltransferase
- Abstract:
- ... In a recent study, we showed that in response to high fat feeding C57BL/6, 129X1, DBA/2 and FVB/N mice all developed glucose intolerance, while BALB/c mice displayed minimal deterioration in glucose tolerance and insulin action. Lipidomic analysis of livers across these five strains has revealed marked strain-specific differences in ceramide (Cer) and sphingomyelin (SM) species with high-fat feedi ...
- DOI:
- 10.1016/j.bbalip.2016.08.016
- https://doi.org/10.1016/j.bbalip.2016.08.016
- Author:
- Vincent Rioux; Frédérique Pédrono; Philippe Legrand
- Source:
- Biochimica et biophysica acta 2011 v.1811 no.1 pp. 1-8
- ISSN:
- 1388-1981
- Subject:
- acyl coenzyme A; animal tissues; cardiovascular diseases; ceramides; cholesterol; correlation; developed countries; dodecanoic acid; eukaryotic cells; fatty acid composition; functional properties; human health; mammals; mortality; myristic acid; myristoylation; palmitic acid; polyunsaturated fatty acids; stearoyl-CoA desaturase; viral proteins
- Abstract:
- ... Myristic acid, the 14-carbon saturated fatty acid (C14:0), usually accounts for small amounts (0.5%–1% weight of total fatty acids) in animal tissues. Since it is a relatively rare molecule in the cells, the specific properties and functional roles of myristic acid have not been fully studied and described. Like other dietary saturated fatty acids (palmitic acid, lauric acid), this fatty acid is u ...
- DOI:
- 10.1016/j.bbalip.2010.09.005
- https://doi.org/10.1016/j.bbalip.2010.09.005
- Author:
- Gabriel S. Matos; Juliana B. Madeira; Caroline Mota Fernandes; Deveney Dasilva; Claudio A. Masuda; Maurizio Del Poeta; Monica Montero-Lomelí
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.9 pp. 158983
- ISSN:
- 1388-1981
- Subject:
- Saccharomyces cerevisiae; ceramides; homeostasis; lipidomics; metabolites; mitosis; phenotype; transcription (genetics); transcription factors
- Abstract:
- ... SBF (Swi4/Swi6 Binding Factor) complex is a crucial regulator of G1/S transition in Saccharomyces cerevisiae. Here, we show that SBF complex is required for myriocin resistance, an inhibitor of sphingolipid synthesis. This phenotype was not shared with MBF complex mutants nor with deletion of the Swi4p downstream targets, CLN1/CLN2. Based on data mining results, we selected putative Swi4p targets ...
- DOI:
- 10.1016/j.bbalip.2021.158983
- https://doi.org/10.1016/j.bbalip.2021.158983
63. Role of endothelial dysfunction in modulating the plasma redox homeostasis in visceral leishmaniasis
- Author:
- Kaustav Dutta Chowdhury; Gargi Sen; Avik Sarkar; Tuli Biswas
- Source:
- Biochimica et biophysica acta 2011 v.1810 no.7 pp. 652-665
- ISSN:
- 0304-4165
- Subject:
- NAD(P)H oxidase (H2O2-forming); animals; bioavailability; ceramides; endothelial cells; endothelial nitric oxide synthase; enzyme-linked immunosorbent assay; flow cytometry; fluorescence; high performance liquid chromatography; homeostasis; nitric oxide; oxidative stress; superoxide anion; visceral leishmaniasis
- Abstract:
- ... BACKGROUND: Evidence in the literature suggests that down-regulation of nitric oxide (NO) is associated with the pathophysiological conditions during visceral leishmaniasis (VL). Here we have investigated the mechanism that leads to the down regulation of systemic NO in the infected condition. Moreover, we have determined whether down regulation of NO is associated with increased generation of rea ...
- DOI:
- 10.1016/j.bbagen.2011.03.019
- https://doi.org/10.1016/j.bbagen.2011.03.019
- Author:
- Christa Buechler; Charalampos Aslanidis
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.5 pp. 158658
- ISSN:
- 1388-1981
- Subject:
- apoptosis; biomarkers; carcinogenicity; cell proliferation; ceramides; cholesterol; early diagnosis; hepatoma; homeostasis; lipid composition; lipid metabolism; liver; liver cirrhosis; metabolites; oxidative stress; pathophysiology; patients; risk; therapeutics; tissues
- Abstract:
- ... Hepatocellular carcinoma (HCC) is an aggressive and widespread cancer. Patients with liver cirrhosis of different aetiologies are at a risk to develop HCC. It is important to know that in approximately 20% of cases primary liver tumors arise in a non-cirrhotic liver. Lipid metabolism is variable in patients with chronic liver diseases, and lipid metabolites involved therein do play a role in the d ...
- DOI:
- 10.1016/j.bbalip.2020.158658
- https://doi.org/10.1016/j.bbalip.2020.158658
65. Role of protein kinase C δ in apoptotic signaling of oxidized phospholipids in RAW 264.7 macrophages
- Author:
- F. Vogl; J. Humpolícková; M. Amaro; D. Koller; H. Köfeler; E. Zenzmaier; M. Hof; A. Hermetter
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.4 pp. 320-330
- ISSN:
- 1388-1981
- Subject:
- aldehydes; apoptosis; atherosclerosis; caspases; ceramides; chemical bonding; color; cytotoxicity; fluorescence microscopy; fluorescent proteins; low density lipoprotein; macrophages; phospholipids; plasma membrane; protein kinase C; small interfering RNA
- Abstract:
- ... The oxidized phospholipids (oxPl) 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC) and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC) are cytotoxic components of oxidized LDL (oxLDL). Sustained exposure to oxLDL or isolated oxPl induces apoptotic signaling in vascular cells, which is a hallmark of the late phase of atherosclerosis. Activation of sphingomyelinase, the c ...
- DOI:
- 10.1016/j.bbalip.2015.12.009
- https://doi.org/10.1016/j.bbalip.2015.12.009
- Author:
- Samir Mandal; Sudip Mukherjee; Kaustav Dutta Chowdhury; Avik Sarkar; Kankana Basu; Soumosish Paul; Debasish Karmakar; Mahasweta Chatterjee; Tuli Biswas; Gobinda Chandra Sadhukhan; Gargi Sen
- Source:
- Biochimica et biophysica acta 2012 v.1820 no.1 pp. 9-23
- ISSN:
- 0304-4165
- Subject:
- apoptosis; ceramides; clotrimazole; confocal microscopy; death; diallyl disulfide; erythrocytes; flow cytometry; gels; immunoblotting; lead; longevity; mass spectrometry; mice; oxidative stress; plasma membrane; potassium; scanning electron microscopy; therapeutics; toxicity
- Abstract:
- ... BACKGROUND: Chronic lead (Pb²⁺) exposure leads to the reduced lifespan of erythrocytes. Oxidative stress and K⁺ loss accelerate Fas translocation into lipid raft microdomains inducing Fas mediated death signaling in these erythrocytes. Pathophysiological-based therapeutic strategies to combat against erythrocyte death were evaluated using garlic-derived organosulfur compounds like diallyl disulfid ...
- DOI:
- 10.1016/j.bbagen.2011.09.019
- https://doi.org/10.1016/j.bbagen.2011.09.019
- Author:
- Nadine Hagen-Euteneuer; Shah Alam; Hannah Rindsfuesser; Dagmar Meyer zu Heringdorf; Gerhild van Echten-Deckert
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.8 pp. 158708
- ISSN:
- 1388-1981
- Subject:
- angiogenesis; biosynthesis; cell viability; ceramides; fibroblasts; gangliosides; glucosylceramides; immunity; lipid metabolism; mice; neurons
- Abstract:
- ... Sphingosine-1-phosphate (S1P) is not only a catabolic intermediate of all sphingolipids but also an evolutionary conserved bioactive lipid with critical functions in cell survival, differentiation, and migration as well as in immunity and angiogenesis. S1P-lyase (SGPL1) irreversibly cleaves S1P in the final step of sphingolipid catabolism. As sphingoid bases and their 1-phosphates are not only met ...
- DOI:
- 10.1016/j.bbalip.2020.158708
- https://doi.org/10.1016/j.bbalip.2020.158708
- Author:
- Walter Boiten; Richard Helder; Jeroen van Smeden; Joke Bouwstra
- Source:
- Biochimica et biophysica acta 2019 v.1864 no.9 pp. 1206-1213
- ISSN:
- 1388-1981
- Subject:
- agonists; antagonists; ceramides; chemical bonding; glucosylceramides; liver; models; skin (animal)
- Abstract:
- ... The cornified lipid envelope (CLE) is a lipid monolayer covalently bound to the outside of corneocytes and is part of the stratum corneum (SC). The CLE is suggested to act as a scaffold for the unbound SC lipids. By profiling the bound CLE ceramides, a new subclass was discovered and identified as an omega-hydroxylated dihydrosphingosine (OdS) ceramide. Bound glucosylceramides were observed in sup ...
- DOI:
- 10.1016/j.bbalip.2019.05.003
- https://doi.org/10.1016/j.bbalip.2019.05.003
- Author:
- Daphne E.C. Boer; Jeroen van Smeden; Hanin Al-Khakany; Elizaveta Melnik; Rianne van Dijk; Samira Absalah; Rob J. Vreeken; Caroline C.P. Haenen; Adriana P.M. Lavrijsen; Herman S. Overkleeft; Johannes M.F.G. Aerts; Joke A. Bouwstra
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.6 pp. 158673
- ISSN:
- 1388-1981
- Subject:
- antimicrobial peptides; atopic dermatitis; biomarkers; ceramides; chemokines; enzyme activity; free fatty acids; glucosylceramidase; lipid composition; patients
- Abstract:
- ... Patients with Atopic Dermatitis (AD) suffer from inflamed skin and skin barrier defects. Proper formation of the outermost part of the skin, the stratum corneum (SC), is crucial for the skin barrier function. In this study we analyzed the localization and activity of lipid enzymes β-glucocerebrosidase (GBA) and acid sphingomyelinase (ASM) in the skin of AD patients and controls. Localization of bo ...
- DOI:
- 10.1016/j.bbalip.2020.158673
- https://doi.org/10.1016/j.bbalip.2020.158673
- Author:
- Tatsuro Mutoh; Yoshiki Niimi; Shota Sakai; Hirohisa Watanabe; Akihiro Ueda; Sayuri Shima; Yasuyuki Igarashi
- Source:
- Biochimica et biophysica acta 2022 v.1867 no.3 pp. 159092
- ISSN:
- 1388-1981
- Subject:
- autoantibodies; ceramides; cerebrospinal fluid; complement; immunochemistry; mass spectrometry; pathogenesis; pathophysiology; sphingomyelins; therapeutics
- Abstract:
- ... Glycolipids are now known to be rapidly converted to mediators for inflammatory reactions or to signaling molecules that control inflammatory events in the nervous system. The present study aimed to explore whether disturbed glycolipids metabolism in the nervous system is present in patients with a neuroinflammatory disorder, encephalo-myelo-radiculo-neuropathy (EMRN), because most EMRN patients h ...
- DOI:
- 10.1016/j.bbalip.2021.159092
- https://doi.org/10.1016/j.bbalip.2021.159092
- Author:
- Patamat Patanapirunhakit; Helen Karlsson; Monique Mulder; Stefan Ljunggren; Delyth Graham; Dilys Freeman
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.8 pp. 158955
- ISSN:
- 1388-1981
- Subject:
- cardiovascular diseases; ceramides; cholesterol; endothelial nitric oxide synthase; endothelium; high density lipoprotein; lifestyle; metabolic diseases; pre-eclampsia; pregnancy
- Abstract:
- ... Plasma high density lipoprotein (HDL) exhibits many functions that render it an effective endothelial protective agent and may underlie its potential role in protecting the maternal vascular endothelium during pregnancy. In non-pregnant individuals, the HDL lipidome is altered in metabolic disease compared to healthy individuals and is linked to reduced cholesterol efflux, an effect that can be re ...
- DOI:
- 10.1016/j.bbalip.2021.158955
- https://doi.org/10.1016/j.bbalip.2021.158955
- Author:
- Raquel Roman Faedo; Gabriel da Silva; Rodrigo Moreira da Silva; Tatiane Resende Ushida; Ricardo Roberto da Silva; Riccardo Lacchini; Leandro Luongo Matos; Luiz Paulo Kowalski; Noberto Peporine Lopes; Andréia Machado Leopoldino
- Source:
- Biochimica et biophysica acta 2022 v.1867 no.1 pp. 159057
- ISSN:
- 1388-1981
- Subject:
- biomarkers; ceramides; glucosylceramides; mass spectrometry; prognosis; squamous cell carcinoma
- Abstract:
- ... Enzymes related to sphingolipids metabolism has been suggested as altered in oral squamous cell carcinoma (OSCC). However, clinical relevance of diverse sphingolipids in OSCC is not fully known. Here, we evaluated sphingolipidomics in plasma and tumor tissues as a tool for diagnosis/prognosis in OSCC patients. Plasma was obtained from 58 controls and 56 OSCC patients, and paired tumor and surgical ...
- DOI:
- 10.1016/j.bbalip.2021.159057
- https://doi.org/10.1016/j.bbalip.2021.159057
- Author:
- Yeun-po Chiang; Zhiqiang Li; Yang Chen; Yu Cao; Xian-Cheng Jiang
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.11 pp. 159017
- ISSN:
- 1388-1981
- Subject:
- ceramides; hydrolysis; mammals; phosphatidylcholines; phosphatidylethanolamines; phosphatidylserines; phospholipase C; phospholipases; sphingomyelins
- Abstract:
- ... Sphingomyelin synthase related protein (SMSr) has no SM synthase activity but has ceramide phosphorylethanolamine (CPE) synthase activity in vitro. Although SMSr is ubiquitously expressed in all tested tissues, the CPE levels in most mammalian tissues or cells are extremely low or undetectable. Therefore, SMSr seems not to be a functional CPE synthase in vivo and its real biological function needs ...
- DOI:
- 10.1016/j.bbalip.2021.159017
- https://doi.org/10.1016/j.bbalip.2021.159017
- Author:
- Tomasz Bednarski; Adam Olichwier; Agnieszka Opasinska; Aleksandra Pyrkowska; Ana-Maria Gan; James M. Ntambi; Pawel Dobrzyn
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.12 pp. 2029-2037
- ISSN:
- 1388-1981
- Subject:
- beta oxidation; cardiomyocytes; ceramides; critical control points; diacylglycerols; fatty acids; free fatty acids; lipid content; lipogenesis; lipolysis; mice; mitochondria; peroxisome proliferator-activated receptors; phosphorylation; stearoyl-CoA desaturase; triacylglycerol lipase; triacylglycerols
- Abstract:
- ... Stearoyl-CoA desaturase 1 (SCD1) has recently been shown to be a critical control point in the regulation of cardiac metabolism and function. Peroxisome proliferator-activated receptor α (PPARα) is an important regulator of myocardial fatty acid uptake and utilization. The present study used SCD1 and PPARα double knockout (SCD1⁻/⁻/PPARα⁻/⁻) mice to test the hypothesis that PPARα is involved in met ...
- DOI:
- 10.1016/j.bbalip.2016.10.005
- https://doi.org/10.1016/j.bbalip.2016.10.005
- Author:
- Iris Meisen; Michael Mormann; Johannes Müthing
- Source:
- Biochimica et biophysica acta 2011 v.1811 no.11 pp. 875-896
- ISSN:
- 1388-1981
- Subject:
- amino alcohols; antibodies; bacteria; ceramides; fatty acids; mass spectrometry; monosaccharides; silica gel; thin layer chromatography; toxins; vertebrates; yields
- Abstract:
- ... Much effort is currently invested in the development of mass spectrometry-based strategies for investigating the entirety of glycosphingolipids (GSLs) of a certain cell type, tissue, organ or body encompassing the respective glycosphingolipidome. As part of the investigation of the vertebrate glycosphingolipidome, GSL analysis is undergoing rapid expansion owing to the application of novel mass sp ...
- DOI:
- 10.1016/j.bbalip.2011.04.006
- https://doi.org/10.1016/j.bbalip.2011.04.006
- Author:
- Takuya Honda; Kaisei Motoyoshi; Junya Kasahara; Kazuyuki Yamagata; Hiromasa Takahashi; Hiroyuki Nakamura; Toshihiko Murayama
- Source:
- Biochimica et biophysica acta 2021 v.1866 no.1 pp. 158817
- ISSN:
- 1388-1981
- Subject:
- cell death; ceramide glucosyltransferase; ceramides; cytotoxicity; glucosylceramides; humans; metabolites; multiple drug resistance; mutants; mutation; phenylalanine; phosphorylation; phosphotransferases (kinases); tyrosine
- Abstract:
- ... Sphingolipids represent a family of cellular lipid-molecules that regulate physiological and pathophysiological processes. Glucosylceramide (GlcCer), the simplest glycosphingolipid (GSL), is synthesized from ceramide and UDP-glucose by GlcCer synthase (GCS). Both GlcCer (and resulting GSLs) and ceramide regulate various cellular functions including cell death and multiple drug resistance. Src fami ...
- DOI:
- 10.1016/j.bbalip.2020.158817
- https://doi.org/10.1016/j.bbalip.2020.158817
- Author:
- Mai Edagawa; Megumi Sawai; Yusuke Ohno; Akio Kihara
- Source:
- Biochimica et biophysica acta 2018 v.1863 no.12 pp. 1441-1448
- ISSN:
- 1388-1981
- Subject:
- cell membranes; ceramides; eukaryotic cells; linoleic acid; mammals; moieties; monounsaturated fatty acids; polyunsaturated fatty acids; small intestine; sphingomyelins; sphingosine N-acyltransferase; spleen; tissue distribution; tissues
- Abstract:
- ... Sphingolipids are multifunctional lipids and a major constituent of the cell membranes of eukaryotes. Although the fatty acid (FA) moiety of sphingolipids is usually a saturated or monounsaturated FA, polyunsaturated FA (PUFA)-containing species also exist in mammalian tissues. In the present study, we showed that C24:2 PUFA-containing ceramide is one of the seven major ceramide species in a wide ...
- DOI:
- 10.1016/j.bbalip.2018.09.002
- https://doi.org/10.1016/j.bbalip.2018.09.002
- Author:
- Joseph V. Varre; William L. Holland; Scott A. Summers
- Source:
- Biochimica et biophysica acta 2022 v.1867 no.6 pp. 159125
- ISSN:
- 1388-1981
- Subject:
- apoptosis; biochemical pathways; cardiovascular diseases; ceramides; diabetes; innate immunity; macrophages; metabolism; obesity; oxidative stress; tumor necrosis factor-alpha
- Abstract:
- ... Obesity leads to persistent increases in immune responses that contribute to cardiometabolic pathologies such as diabetes and cardiovascular disease. Pro-inflammatory macrophages infiltrate the expanding fat mass, which leads to increased production of cytokines such as tumor necrosis factor-alpha. Moreover, saturated fatty acids enhance signaling through the toll-like receptors involved in innate ...
- DOI:
- 10.1016/j.bbalip.2022.159125
- https://doi.org/10.1016/j.bbalip.2022.159125
79. The adaptation of lipid profile of human fibroblasts to alginate 2D films and 3D printed scaffolds
- Author:
- Ilaria Zanotti; Silvia Marando; Giulia Remaggi; Carlo Bergonzi; Franco Bernini; Ruggero Bettini; Lisa Elviri
- Source:
- Biochimica et biophysica acta 2021 v.1865 no.1 pp. 129734
- ISSN:
- 0304-4165
- Subject:
- alginates; biocompatible materials; cell membranes; ceramides; fibroblasts; geometry; humans; hydrogels; lipid composition; lipidomics; lysophosphatidylcholine; mechanical properties; sowing; three-dimensional printing; water content
- Abstract:
- ... The investigation of the interactions between cells and active materials is pivotal in the emerging 3D printing-biomaterial application fields. Here, lipidomics has been used to explore the early impact of alginate (ALG) hydrogel architecture (2D films or 3D printed scaffolds) and the type of gelling agent (CaCl₂ or FeCl₃) on the lipid profile of human fibroblasts.2D and 3D ALG scaffolds were prep ...
- DOI:
- 10.1016/j.bbagen.2020.129734
- https://doi.org/10.1016/j.bbagen.2020.129734
- Author:
- Giorgio Cozza; Mauro Salvi; Sourav Banerjee; Elena Tibaldi; Vincent S. Tagliabracci; Jack E. Dixon; Lorenzo A. Pinna
- Source:
- Biochimica et biophysica acta 2015 v.1854 no.10 pp. 1718-1726
- ISSN:
- 1570-9639
- Subject:
- adenosine triphosphate; biochemical pathways; biomineralization; casein; ceramides; drugs; heat inactivation; homeostasis; immunosuppression; magnesium; manganese; metabolites; mutants; non-specific serine/threonine protein kinase; phosphates; protein secretion; sclerosis; serine; sphingosine
- Abstract:
- ... Fam20C is an atypical kinase implicated in bio-mineralization and phosphate homeostasis disorders, and has recently been shown to account for the activity of an orphan enzyme (“genuine casein kinase”, G-CK) previously characterized for its ability to phosphorylate casein and a plethora of secreted proteins at serine residues specified by the S-x-E/pS motif. Fam20C/G-CK activity is only appreciable ...
- DOI:
- 10.1016/j.bbapap.2015.04.023
- https://doi.org/10.1016/j.bbapap.2015.04.023
- Author:
- Tetsuya Hirabayashi; Makoto Murakami; Akio Kihara
- Source:
- Biochimica et biophysica acta 2019 v.1864 no.6 pp. 869-879
- ISSN:
- 1388-1981
- Subject:
- biochemical pathways; biosynthesis; ceramides; gene targeting; genes; ichthyosis; keratinocytes; linoleic acid; lipid metabolism; mutation; phospholipase A2; phospholipases; phospholipids; triacylglycerols
- Abstract:
- ... The human genome encodes nine enzymes belonging to the patatin-like phospholipase domain-containing lipase (PNPLA)/Ca2+-independent phospholipase A2 (iPLA2) family. Although most PNPLA/iPLA2 enzymes are widely distributed and act on phospholipids or neutral lipids as (phospho)lipases to play homeostatic roles in lipid metabolism, the function of PNPLA1 remained a mystery until a few years ago. How ...
- DOI:
- 10.1016/j.bbalip.2018.09.010
- https://doi.org/10.1016/j.bbalip.2018.09.010
- Author:
- Qun Zhu; Lianku Lin; Qi Cheng; Qing Xu; Jingmei Zhang; Stephen Tomlinson; Junfei Jin; Xiaoping Chen; Songqing He
- Source:
- Biochimica et biophysica acta 2012 v.1821 no.12 pp. 1453-1461
- ISSN:
- 1388-1981
- Subject:
- apoptosis; caspases; ceramides; hepatocytes; humans; hypoxia; ischemia; liver; mouth neoplasms; neoplasm cells
- Abstract:
- ... A previous data showed that the hypoxia mimetic compound CoCl₂ induced cleavage of HuR and subsequent apoptosis in human oral cancer cells. We also previously demonstrated that exposure of NT-2 human neuronal precursor cells to hypoxia resulted in changes in sphingolipid levels and apoptosis. Since it is known that CoCl₂ induces cleavage of HuR, we investigated whether there is a link between HuR ...
- DOI:
- 10.1016/j.bbalip.2012.08.005
- https://doi.org/10.1016/j.bbalip.2012.08.005
- Author:
- Iris D. Zelnik; Ana E. Ventura; Jiyoon L. Kim; Liana C. Silva; Anthony H. Futerman
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.1 pp. 158489
- ISSN:
- 1388-1981
- Subject:
- Golgi apparatus; apoptosis; ceramides; endoplasmic reticulum
- Abstract:
- ... Sphingolipids (SLs) are an important class of membrane lipids containing a long chain sphingoid base backbone. SL synthesis is compartmentalized between two major cell organelles, the endoplasmic reticulum (ER) and the Golgi apparatus. The initial steps of sphingolipid synthesis take place in the ER, where the simplest SL, ceramide, is synthesized. Although ceramide is a critical membrane componen ...
- DOI:
- 10.1016/j.bbalip.2019.06.015
- https://doi.org/10.1016/j.bbalip.2019.06.015
- Author:
- Takayuki Sassa; Shota Suto; Yuriko Okayasu; Akio Kihara
- Source:
- Biochimica et biophysica acta 2012 v.1821 no.7 pp. 1031-1037
- ISSN:
- 1388-1981
- Subject:
- apoptosis; ceramides; mammals; metabolism; plasma membrane; tissues; ultraviolet radiation
- Abstract:
- ... Sphingolipids, major lipid components of the eukaryotic plasma membrane, have a variety of physiological functions and have been associated with many diseases. They have also been implicated in apoptosis. Sphingolipids are heterogeneous in their acyl chain length, with long-chain (C16) and very long-chain (C24) sphingolipids being predominant in most mammalian tissues. We demonstrate that knockdow ...
- DOI:
- 10.1016/j.bbalip.2012.04.008
- https://doi.org/10.1016/j.bbalip.2012.04.008
- Author:
- Emily Chen; Michael A. Kiebish; Justice McDaniel; Fei Gao; Niven R. Narain; Rangaprasad Sarangarajan; Gergely Kacso; Dora Ravasz; Thomas N. Seyfried; Vera Adam-Vizi; Christos Chinopoulos
- Source:
- Biochimica et biophysica acta 2016 v.1861 no.11 pp. 1727-1735
- ISSN:
- 1388-1981
- Subject:
- Artemia franciscana; animals; ceramides; embryogenesis; hypoxia; lipid composition; mitochondria; phosphatidylethanolamines; phosphatidylglycerols; phosphatidylserines; proteins; salinity
- Abstract:
- ... Encysted embryos (cysts) of the crustacean Artemia franciscana exhibit enormous tolerance to adverse conditions encompassing high doses of radiation, years of anoxia, desiccation and extreme salinity. So far, several mechanisms have been proposed to contribute to this extremophilia, however, none were sought in the lipid profile of the cysts. Here in, we used high resolution shotgun lipidomics sui ...
- DOI:
- 10.1016/j.bbalip.2016.08.007
- https://doi.org/10.1016/j.bbalip.2016.08.007