Subject: "serine C-palmitoyltransferase" / Journal: Biochimica et biophysica acta / Subject: enzymology and biosynthesis

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Author:: Ikushiro, Hiroko; Hayashi, Hideyuki
Source:: Biochimica et biophysica acta 2011 v.1814 no.11 pp. 1474-1480
ISSN:: 1878-1454
Subject:: serine C-palmitoyltransferase, etc ; biosynthesis; pyridoxal phosphate; sphingolipids; spectroscopy; enzymology; Show all 6 Subjects
Abstract:: ... Serine palmitoyltransferase, which is one of the α-oxamine synthase family enzymes, catalyzes the condensation reaction of L-serine and palmitoyl-CoA to form 3-ketodihydrosphingosine, the first and rate-determining step of the sphingolipid biosynthesis. As with other α-oxamine synthase family enzymes, the catalytic reaction is composed of multiple elementary steps, and the mechanism to control the ...
DOI:: 10.1016/j.bbapap.2011.02.005
: http://dx.doi.org/10.1016/j.bbapap.2011.02.005