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- Madhu, Dhanya; Khadir, Abdelkrim; Hammad, Maha; Kavalakatt, Sina; Dehbi, Mohammed; Al-Mulla, Fahd; Abubaker, Jehad; Tiss, Ali
- Biochimica et biophysica acta 2020 v.1868 no.7 pp. 140426
- glucagon-like peptide 1, etc ; Western blotting; apoptosis; cell growth; cell proliferation; endoplasmic reticulum stress; heat shock proteins; heat shock response; homeostasis; inflammation; islets of Langerhans; lipotoxicity; mass spectrometry; mice; mitogen-activated protein kinase; noninsulin-dependent diabetes mellitus; palmitic acid; pathogenesis; phosphorylation; protective effect; proteomics; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; Show all 23 Subjects
- ... Lipotoxicity, an important factor in the pathogenesis of diabetes, leads to defective β-cell proliferation and increased apoptosis. Glucagon-like peptide-1 (GLP-1) analogs, which are used to treat type 2 diabetes, reduce endoplasmic reticulum stress and inflammation in pancreatic β-cells and improve their survival. However, their effects on the heat shock response (HSR) have not been elucidated ye ...