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- Parker, Michael W., et al. Show all 5 Authors
- Biochimie 2016 v.128-129 pp. 114-121
- DNA; DNA primers; binding capacity; humans; models; molecular dynamics; mutants; mutation; neoplasms; ribonucleoproteins; telomerase; telomeres
- ... The ribonucleoprotein enzyme telomerase maintains telomeres and is essential for cellular immortality in most cancers. Insight into the telomerase mechanism can be gained from short telomere syndromes, in which mutation of telomerase components manifests in telomere dysfunction. We carried out detailed kinetic analyses and molecular modelling of a disease-associated mutant in the C-terminal extens ...