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- Johnson, W. Thomas; Prohaska, Joseph R.
- Biofactors 2000 v.11 no.3 pp. 163–169
- copper; pregnancy; maternal nutrition; protein kinase C; protein content; cerebellum; gender differences; males; females; rats
- ... Change in cerebellar protein kinase C gamma (PKC(γ)) content caused by perinatal copper (Cu) deficiency was determined in 22-day old rats. The offspring of dams with low Cu intake during gestation and lactation exhibited signs characteristic of Cu deficiency including anemia, greater than 90% reduction in liver Cu concentration, and undetectable serum ceruloplasmin. In addition, brain Cu concentra ...