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You searched for: Journal Biological trace element research Remove constraint Journal: Biological trace element research Publication Year 2014 Remove constraint Publication Year: 2014 Source 2014 v.158 no.2 Remove constraint Source: 2014 v.158 no.2
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1. Cadmium Induces PC12 Cells Apoptosis via an Extracellular Signal-Regulated Kinase and c-Jun N-Terminal Kinase-Mediated Mitochondrial Apoptotic Pathway

Author:
Jiang, Chenyang; Yuan, Yan; Hu, Feifei; Wang, Qiwen; Zhang, Kangbao; Wang, Yi; Gu, Jianhong; Liu, Xuezhong; Bian, Jianchun; Liu, Zongping
Source:
Biological trace element research 2014 v.158 no.2 pp. 249-258
ISSN:
0163-4984
Subject:
apoptosis; cadmium; caspase-3; cell viability; cytochrome c; mitogen-activated protein kinase; models; phosphorylation
Abstract:
... To investigate the role of mitogen-activated protein kinase (MAPK) and downstream events in cadmium (Cd)-induced neuronal apoptosis executed via the mitochondrial apoptotic pathway, this study used the PC-12 cell line as a neuronal model. The result showed that Cd significantly decreased cell viability and the Bcl-2 / Bax ratio and increased the percentage of apoptotic cells, release of cytochrome ...
DOI:
10.1007/s12011-014-9918-6
PubMed:
24577723

2. Cerebellar Hypoplasia in Mice Lacking Selenoprotein Biosynthesis in Neurons

Author:
Wirth, Eva K.; Bharathi, B. Suman; Hatfield, Dolph; Conrad, Marcus; Brielmeier, Markus; Schweizer, Ulrich
Source:
Biological trace element research 2014 v.158 no.2 pp. 203-210
ISSN:
0163-4984
Subject:
atrophy; biochemical pathways; biosynthesis; calcium; cell death; cell proliferation; cerebellum; enzyme activity; gene deletion; genes; glutathione peroxidase; homeostasis; humans; interneurons; mice; models; mutants; patients; phospholipid-hydroperoxide glutathione peroxidase; protein synthesis; selenium; selenocysteine; selenoproteins; transfer RNA
Abstract:
... Selenium exerts many, if not most, of its physiological functions as a selenocysteine moiety in proteins. Selenoproteins are involved in many biochemical processes including regulation of cellular redox state, calcium homeostasis, protein biosynthesis, and degradation. A neurodevelopmental syndrome called progressive cerebello-cortical atrophy (PCCA) is caused by mutations in the selenocysteine sy ...
DOI:
10.1007/s12011-014-9920-z
PubMed:
24599700
PubMed Central:
PMC3984410

3. Concentrations of Chromium, Selenium, and Copper in the Hair of Viscerally Obese Adults are Associated with Insulin Resistance

Author:
Kim, Ha-Na; Song, Sang-Wook
Source:
Biological trace element research 2014 v.158 no.2 pp. 152-157
ISSN:
0163-4984
Subject:
adiposity; adults; bioelectrical impedance; blood glucose; cardiovascular diseases; chromium; correlation; cross-sectional studies; homeostasis; insulin; insulin resistance; mineral content; minerals; obesity; selenium
Abstract:
... Visceral adiposity is linked to the development of insulin resistance, which is a condition that may contribute to metabolic abnormalities and cardiovascular disease. Various minerals play essential roles in different metabolic functions in the body. Thus, the relationships between mineral concentrations in the hair and insulin resistance were analyzed in 144 Korean adults (71 viscerally obese sub ...
DOI:
10.1007/s12011-014-9934-6
PubMed:
24643468

4. Distinct Response of Lactating and Nonlactating Rats Exposed to Inorganic Mercury on Hepatic δ-Aminolevulinic Acid Dehydratase Activity

Author:
Oliveira, Cláudia S.; Favero, Alexandre M.; Franciscato, Carina; da Luz, Sônia C. A.; Pereira, Maria Ester
Source:
Biological trace element research 2014 v.158 no.2 pp. 230-237
ISSN:
0163-4984
Subject:
alanine transaminase; aspartate transaminase; food intake; lactation; liver; mercury; pups; rats
Abstract:
... This study investigated if lactating and nonlactating rats presented differences in relation to hepatic sensitivity to HgCl₂and the potential preventive role of ZnCl₂. Lactating (days 3–12 of lactation) and nonlactating rats received 27 mg/kg ZnCl₂for five consecutive days and 5 mg/kg HgCl₂for five subsequent days. Lactating and nonlactating rats exposed to HgCl₂presented a decrease in food intake ...
DOI:
10.1007/s12011-014-9931-9
PubMed:
24634288

5. Effect of Water-Soluble Silicon Supplementation on Bone Status and Balance of Calcium and Magnesium in Male Mice

Author:
Kim, Mi-Hyun; Kim, Eun-Jin; Jung, Ji-Youn; Choi, Mi-Kyeong
Source:
Biological trace element research 2014 v.158 no.2 pp. 238-242
ISSN:
0163-4984
Subject:
adults; alkaline phosphatase; blood serum; bone density; bone metabolism; calcium; femur; magnesium; males; mice; rats; silicon; skeletal development; tibia; weight gain
Abstract:
... Silicon (Si) is important for the growth and development of bone and connective tissues. Several studies have reported that Si supplementation improved bone mineral density (BMD) in female ovarectomized rats. However, few studies have investigated the effects of Si supplementation on bone status and bone metabolism in male animals. The purpose of this study was to investigate the effects of Si sup ...
DOI:
10.1007/s12011-014-9936-4
PubMed:
24664270

6. Effects of Dietary Copper on Nutrient Digestibility, Tissular Copper Deposition and Fur Quality of Growing-Furring Mink (Mustela vison)

Author:
Wu, Xuezhuang; Liu, Zhi; Zhang, Tietao; Yang, Ying; Yang, Fuhe; Gao, Xiuhua
Source:
Biological trace element research 2014 v.158 no.2 pp. 166-175
ISSN:
0163-4984
Subject:
Neovison vison; alanine transaminase; albumins; aspartate transaminase; blood serum; body weight; color; copper; copper sulfate; dietary fat; dietary supplements; digestibility; digestion; ferroxidase; fur; growth performance; leather; liver; mink
Abstract:
... The present study investigated the effects of dietary copper (Cu) on growth performance and fur quality in growing-furring minks. One hundred and five standard dark female minks were randomly assigned to seven groups with the following dietary treatments: basal diet with no supplemental Cu (control) and basal diet supplemented with either 6, 12, 24, 48, 96 or 192 mg/kg Cu from copper sulphate, res ...
DOI:
10.1007/s12011-014-9933-7
PubMed:
24668161

7. Effects of Dietary Supplementation with Vitamin C and Vitamin E and Their Combination on Growth Performance, Some Biochemical Parameters, and Oxidative Stress Induced by Copper Toxicity in Broilers

Author:
Cinar, Miyase; Yildirim, Ebru; Yigit, A.Arzu; Yalcinkaya, Ilkay; Duru, Ozkan; Kisa, Uçler; Atmaca, Nurgul
Source:
Biological trace element research 2014 v.158 no.2 pp. 186-196
ISSN:
0163-4984
Subject:
alanine transaminase; alkaline phosphatase; ascorbic acid; aspartate transaminase; body weight; chicks; copper; dietary supplements; erythrocytes; feed conversion; glutathione peroxidase; growth performance; iron; lipid peroxidation; malondialdehyde; oxidative stress; superoxide dismutase; toxicity; uric acid; vitamin A; vitamin E
Abstract:
... This study investigated effects of dietary supplementation with vitamin C, vitamin E on performance, biochemical parameters, and oxidative stress induced by copper toxicity in broilers. A total of 240, 1-day-old, broilers were assigned to eight groups with three replicates of 10 chicks each. The groups were fed on the following diets: control (basal diet), vitamin C (250 mg/kg diet), vitamin E (25 ...
DOI:
10.1007/s12011-014-9926-6
PubMed:
24615553

8. Effects of Selenium on Liver and Muscle Contents and Urinary Excretion of Zinc, Copper, Iron and Manganese

Author:
Monedero-Prieto, María José; González-Pérez, José María; González-Reimers, Emilio; Hernández-Pérez, Onán; Monereo-Muñoz, María; Galindo-Martín, Luis; Quintero-Platt, Geraldine; Abreu-González, Pedro
Source:
Biological trace element research 2014 v.158 no.2 pp. 224-229
ISSN:
0163-4984
Subject:
adults; antioxidants; biochemical pathways; blood serum; copper; excretion; experimental design; glutathione peroxidase; iron; liver; malondialdehyde; manganese; metabolism; oxidative stress; pathogenesis; rats; selenium; selenomethionine; zinc
Abstract:
... Selenium is a main component of glutathione peroxidase (GPX), a key antioxidant enzyme. Other elements, such as zinc, copper, manganese and iron, are also involved in the pathogenesis of oxidative damage as well as in other important metabolic pathways. The effects of selenium supplementation on the metabolism of these elements have yield controversial results .The aim of this study is to analyse ...
DOI:
10.1007/s12011-014-9928-4
PubMed:
24622908

9. Evaluation of Selenium, Redox Status and Their Association with Plasma Amyloid/Tau in Alzheimer’s Disease

Author:
Krishnan, Sreeram; Rani, P.
Source:
Biological trace element research 2014 v.158 no.2 pp. 158-165
ISSN:
0163-4984
Subject:
Alzheimer disease; glutathione; NADP-glucose-6-phosphate dehydrogenase; glutathione-disulfide reductase; malondialdehyde; selenoproteins; selenium; longitudinal studies; cerebrospinal fluid; glutathione peroxidase; amyloid; patients; antioxidant activity; blood; antioxidants; oxidative stress; India
Abstract:
... The aim of the study was to evaluate blood selenium and antioxidants as possible oxidative stress markers in Alzheimer’s disease (AD) along with amyloid β42 (Aβ42) and tau by comparing them with vascular dementia (VD) and age-matched healthy controls. Selenium, total tau, Aβ42, glutathione (GSH) and malondialdehyde (MDA) levels and the activities of antioxidant enzymes were analysed in the blood o ...
DOI:
10.1007/s12011-014-9930-x
PubMed:
24682919

10. Interaction Between Selenium and Mercury in Biological Samples of Pakistani Myocardial Infarction Patients at Different Stages as Related to Controls

Author:
Afridi, Hassan Imran; Kazi, Tasneem Gul; Talpur, Farah Naz; Kazi, Atif; Arain, Sadaf Sadia; Arain, Salma Aslam; Brahman, Kapil Dev; Panhwar, Abdul Haleem; Naeemullah,
Source:
Biological trace element research 2014 v.158 no.2 pp. 143-151
ISSN:
0163-4984
Subject:
atomic absorption spectrometry; blood; cardiac arrest; mercury; myocardial infarction; pathogenesis; patients; risk; selenium; urine; Pakistan
Abstract:
... It has been speculated that trace elements may a play role in the pathogenesis of heart diseases. In the present study, we aimed to assess the levels of selenium (Se) and mercury (Hg) in biological samples (whole blood, urine, and scalp hair) of myocardial infarction (MI) patients of both genders (age range 45–60 years) at the first, second, and third heart attack (n = 130), hospitalized in a card ...
DOI:
10.1007/s12011-014-9932-8
PubMed:
24643467

11. Kinetics Absorption Characteristics of Ferrous Glycinate in SD Rats and Its Impact on the Relevant Transport Protein

Author:
Zhuo, Zhao; Fang, Shenglin; Yue, Min; Zhang, Yiwei; Feng, Jie
Source:
Biological trace element research 2014 v.158 no.2 pp. 197-202
ISSN:
0163-4984
Subject:
absorption; bioavailability; blood; duodenum; ferrous sulfate; iron; pharmacokinetics; rats; tail; transport proteins
Abstract:
... Ferrous glycinate (Fe-Gly) maintains high bioavailability in animals, but its exact absorption mechanism is still unknown. Here, we studied on the absorption kinetics of ferrous glycinate and its impact on the relevant transport protein in Sprague-Dawley (SD) rats. A total of 72 SD rats (male, BW 100 ± 6.25 g) were randomly allotted to three treatments. These treatments were perfused with 1 mL of ...
DOI:
10.1007/s12011-014-9906-x
PubMed:
24615551

12. Non-intercalative, Deoxyribose Binding of Boric Acid to Calf Thymus DNA

Author:
Ozdemir, Ayse; Gursaclı, Refiye Tekiner; Tekinay, Turgay
Source:
Biological trace element research 2014 v.158 no.2 pp. 268-274
ISSN:
0163-4984
Subject:
DNA; absorbance; binding properties; boric acid; calorimetry; calves; spectroscopy; sugars; titration; transmission electron microscopy
Abstract:
... The present study characterizes the effects of the boric acid binding on calf thymus DNA (ct-DNA) by spectroscopic and calorimetric methods. UV–Vis absorbance spectroscopy, circular dichroism (CD) spectroscopy, transmission electron microscopy (TEM), isothermal titration calorimetry (ITC), and Fourier transform infrared (FT-IR) spectroscopy were employed to characterize binding properties. Changes ...
DOI:
10.1007/s12011-014-9924-8
PubMed:
24652629

13. Protective Effects of Selenium on Cadmium-Induced Brain Damage in Chickens

Author:
Liu, Li-li; Li, Cheng-ming; Zhang, Zi-wei; Zhang, Jiu-li; Yao, Hai-dong; Xu, Shi-wen
Source:
Biological trace element research 2014 v.158 no.2 pp. 176-185
ISSN:
0163-4984
Subject:
brain damage; cadmium; cerebellum; cerebrum; chickens; diet; gene expression; histopathology; messenger RNA; nitric oxide; nitric oxide synthase; oxidative stress; protective effect; selenium
Abstract:
... Selenium (Se) is an important dietary micronutrient with antioxidative roles. Cadmium (Cd), a ubiquitous environmental pollutant, is known to cause brain lesion in rats and humans. However, little is reported about the deleterious effects of subchronic Cd exposure on the brain of poultry and the protective roles on the brain by Se against Cd. The aim of this study was to investigate the protective ...
DOI:
10.1007/s12011-014-9919-5
PubMed:
24573406

14. Selenium Reduces Oxidative Stress and Calcium Entry Through TRPV1 Channels in the Neutrophils of Patients with Polycystic Ovary Syndrome

Author:
Köse, Seyit Ali; Nazıroğlu, Mustafa
Source:
Biological trace element research 2014 v.158 no.2 pp. 136-142
ISSN:
0163-4984
Subject:
antioxidants; calcium; calcium channels; glutathione; glutathione peroxidase; humans; lipid peroxidation; neutrophils; oxidation; oxidative stress; pathogenesis; patients; polycystic ovary syndrome; protective effect; selenium; sodium selenite
Abstract:
... Polycystic ovary syndrome (PCOS) is a common inflammatory disease with an uncertain pathogenesis, although one consistent finding is increased neutrophil activity. It has been recently reported that the essential antioxidant element selenium has protective effects on oxidative stress and cytosolic Ca²⁺ concentrations in human neutrophil. We aimed to investigate the effects of selenium on oxidative ...
DOI:
10.1007/s12011-014-9929-3
PubMed:
24634287

15. Serum Zn Levels and Cu/Zn Ratios Worsen in Hemodialysis Patients, Implying Increased Cardiovascular Risk: A 2-Year Longitudinal Study

Author:
Reina de la Torre, Maria Luisa; Navarro-Alarcón, Miguel; del Moral, Loreto Martí; de la Serrana, Herminia López-Gª; Palomares-Bayo, Magdalena; Oliveras López, María Jesús; Herrera, Rosa María Blanca; Agil, Ahmad
Source:
Biological trace element research 2014 v.158 no.2 pp. 129-135
ISSN:
0163-4984
Subject:
blood serum; cardiovascular diseases; copper; correlation; diuretics; etiology; hemodialysis; hyperlipidemia; inflammation; longitudinal studies; low density lipoprotein cholesterol; oxidative stress; patients; risk; zinc
Abstract:
... The objective of this study was to analyze serum Zn and Cu concentrations and Cu/Zn ratios in 116 hemodialysis patients (HPs) over a 2-year longitudinal study at four time points (6-month intervals). The relation exerted on these values by 26 biochemical and nutritional indexes, the age and drug consumption of the patients, and the etiology of their disease were also evaluated. A healthy control g ...
DOI:
10.1007/s12011-014-9921-y
PubMed:
24585396

16. The Effect of Copper on the mRNA Expression Profile of Xenobiotic-Metabolizing Enzymes in Cultured Rat H4-II-E Cells

Author:
Darwish, Wageh Sobhy; Ikenaka, Yoshinori; Nakayama, Shouta; Ishizuka, Mayumi
Source:
Biological trace element research 2014 v.158 no.2 pp. 243-248
ISSN:
0163-4984
Subject:
copper; copper sulfate; cytochrome P-450; enzymes; gene expression; gene expression regulation; liver; messenger RNA; metallothionein; quantitative polymerase chain reaction; rats; toxicity
Abstract:
... Copper (Cu²⁺) is an essential element that plays important roles in physiological functions of the body. However, high Cu²⁺levels can have toxic implications. This study aims to investigate the constitutive response to Cu²⁺exposure of xenobiotic-metabolizing enzymes in cultured rat liver (H4-II-E) cell lines. Rat cells were exposed to copper sulfate (0–500 μM) for 24 h. The effects of Cu²⁺on the m ...
DOI:
10.1007/s12011-014-9915-9
PubMed:
24599699

17. The Protective Effect of Vanadium Against Diabetic Cataracts in Diabetic Rat Model

Author:
Sun, Lei; Shi, De-Jing; Gao, Xiang-Chun; Mi, Shu-Yong; Yu, Ying; Han, Qing
Source:
Biological trace element research 2014 v.158 no.2 pp. 219-223
ISSN:
0163-4984
Subject:
aldehyde reductase; animal models; blood glucose; cataract; diabetes; hyperglycemia; malondialdehyde; mechanism of action; oxidative stress; protective effect; rats; sorbitol; superoxide dismutase; vanadium
Abstract:
... The present study was designed to investigate the effect of vanadium in alloxan-induced diabetes and cataract in rats. Different doses of vanadium was administered once daily for 8 weeks to alloxan-induced diabetic rats. To know the mechanism of action of vanadium, lens malondialdehyde (MDA), protein carbonyl content, activity of superoxide dismutase (SOD), activities of aldose reductase (AR), and ...
DOI:
10.1007/s12011-014-9925-7
PubMed:
24604151

18. Zinc Modulates High Glucose-Induced Apoptosis by Suppressing Oxidative Stress in Renal Tubular Epithelial Cells

Author:
Zhang, Xiuli; Zhao, Yue; Chu, Qingqing; Wang, Zhan-You; Li, Hongjuan; Chi, Zhi-Hong
Source:
Biological trace element research 2014 v.158 no.2 pp. 259-267
ISSN:
0163-4984
Subject:
reactive oxygen species; epithelial cells; signal transduction; cytosol; mitogen-activated protein kinase; oxidative stress; protective effect; cell viability; glucose; electron transfer; mitochondria; hyperglycemia; apoptosis; caspase-3; diabetic nephropathy; cytotoxicity; caspase-9; zinc; inflammation; cytochrome c; gene induction
Abstract:
... Hyperglycemia is a characteristic of diabetic nephropathy, inducing renal tubular cell apoptosis by eliciting oxidative stress and inflammation. Zinc (Zn) is known as an essential trace element in many enzymes and proteins involved in antioxidant defenses, electron transport, and exerting antiapoptotic or cytoprotective effects. In this study, the underlying mechanisms involved in the protective e ...
DOI:
10.1007/s12011-014-9922-x
PubMed:
24591003

19. Zinc Supplementation Alleviates Diabetic Peripheral Neuropathy by Inhibiting Oxidative Stress and Upregulating Metallothionein in Peripheral Nerves of Diabetic Rats

Author:
liu, Fangyao; Ma, Feiyu; Kong, Gengbin; Wu, Kezhou; Deng, Zhihua; Wang, Hu
Source:
Biological trace element research 2014 v.158 no.2 pp. 211-218
ISSN:
0163-4984
Subject:
diabetes; lipid peroxidation; malondialdehyde; messenger RNA; metallothionein; nerve tissue; oxidative stress; peripheral nerves; peripheral nervous system diseases; protective effect; rats; streptozotocin; tibia; zinc
Abstract:
... We investigated the effect of zinc supplementation on the expression of metallothionein, lipid peroxidation (malondialdehyde, MDA), and poly(ADP-ribose) polymerase-1 (PARP-1) in the sciatic nerve, motor nerve conduction velocity of the left sciatic posterior tibial nerve in streptozotocin (STZ)-induced diabetic rats. Twenty-four male rats were equally divided into four groups. The first group serv ...
DOI:
10.1007/s12011-014-9923-9
PubMed:
24615552