Author: "YANG, Guang" / Journal: Biological trace element research / Publication Year: 2014 / Subject: cell culture and DNA methylation / Text Availability: Citation in PubAg

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Author:: Yang, Guang, et al. ; Zhu, Yanhe; Dong, Xin; Duan, Zongming; Niu, Xiaolin; Wei, Jin; Show all 6 Authors
Source:: Biological trace element research 2014 v.159 no.1-3 pp. 69-80
ISSN:: 0163-4984
Subject:: DNA; DNA methylation; animal models; cardiomyopathy; cell culture; epigenetics; etiology; gene expression; gene expression regulation; genes; genomic islands; inflammation; messenger RNA; myocardium; patients; precipitin tests; promoter regions; rats; reverse transcriptase polymerase chain reaction; selenium
Abstract:: ... Keshan disease (KD) is a fatal dilated cardiomyopathy with unknown etiology, and selenium deficiency is considered the main cause of KD. Several observations implicate a role for altered DNA methylation in selenium deficiency-related diseases. The aim of the present study was to investigate the epigenetic effects of selenium (Se) on DNA methylation and gene expression in Keshan disease. Using meth ...
DOI:: 10.1007/s12011-014-9985-8
PubMed:: 24811888
: http://dx.doi.org/10.1007/s12011-014-9985-8