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1. TLR2-ICAM1-Gadd45α Axis Mediates the Epigenetic Effect of Selenium on DNA Methylation and Gene Expression in Keshan Disease

Author:
Yang, Guang,   et al.   ; Zhu, Yanhe; Dong, Xin; Duan, Zongming; Niu, Xiaolin; Wei, Jin;     Show all 6 Authors
Source:
Biological trace element research 2014 v.159 no.1-3 pp. 69-80
ISSN:
0163-4984
Subject:
DNA; DNA methylation; animal models; cardiomyopathy; cell culture; epigenetics; etiology; gene expression; gene expression regulation; genes; genomic islands; inflammation; messenger RNA; myocardium; patients; precipitin tests; promoter regions; rats; reverse transcriptase polymerase chain reaction; selenium
Abstract:
... Keshan disease (KD) is a fatal dilated cardiomyopathy with unknown etiology, and selenium deficiency is considered the main cause of KD. Several observations implicate a role for altered DNA methylation in selenium deficiency-related diseases. The aim of the present study was to investigate the epigenetic effects of selenium (Se) on DNA methylation and gene expression in Keshan disease. Using meth ...
DOI:
10.1007/s12011-014-9985-8
PubMed:
24811888