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- Yang, Guang, et al. Show all 6 Authors
- Biological trace element research 2014 v.159 no.1-3 pp. 69-80
- DNA; DNA methylation; animal models; cardiomyopathy; cell culture; epigenetics; etiology; gene expression; gene expression regulation; genes; genomic islands; inflammation; messenger RNA; myocardium; patients; precipitin tests; promoter regions; rats; reverse transcriptase polymerase chain reaction; selenium
- ... Keshan disease (KD) is a fatal dilated cardiomyopathy with unknown etiology, and selenium deficiency is considered the main cause of KD. Several observations implicate a role for altered DNA methylation in selenium deficiency-related diseases. The aim of the present study was to investigate the epigenetic effects of selenium (Se) on DNA methylation and gene expression in Keshan disease. Using meth ...