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- Hashii, Noritaka, et al. Show all 5 Authors
- Biologicals 2019 v.58 pp. 35-43
- biopharmaceuticals; consensus sequence; databases; dissociation; glucagon-like peptide 1; glycosylation; liquid chromatography; mammals; mass spectrometry; peptides; proteins; therapeutics
- ... Unexpected O-glycosylations, including O-xylosylations and mucin-type O-glycosylations, have been reported in recent glycosylation analyses of Fc-fusion proteins produced in mammalian cell expression systems. This observation suggests that therapeutic proteins with novel structures can undergo unintended O-glycosylations, having implications regarding their efficacy and safety. Therefore, the impl ...