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You searched for: Author "Ma, Xiaoqian" Remove constraint Author: "Ma, Xiaoqian" Journal Biomacromolecules Remove constraint Journal: Biomacromolecules Publication Year 2019 Remove constraint Publication Year: 2019
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1. Enhanced Tumor Penetration and Chemotherapy Efficiency by Covalent Self-Assembled Nanomicelle Responsive to Tumor Microenvironment

Author:
Ma, Xiaoqian,   et al.   ; Bai, Shuang; Zhang, Xiaoli; Ma, Xianbin; Jia, Die; Shi, Xiaoxiao; Shao, Jinjun; Xue, Peng; Kang, Yuejun; Xu, Zhigang;     Show all 10 Authors
Source:
Biomacromolecules 2019 v.20 no.7 pp. 2637-2648
ISSN:
1526-4602
Subject:
cell membranes; composite polymers; disulfide bonds; drug therapy; drugs; hydrophilicity; micelles; nanomedicine; neoplasm cells; neoplasms
Abstract:
... The physicochemical properties of nanomedicine can be altered with a tumor microenvironment, which influence the precise delivery of drug molecules to the lesion. Thus, the therapeutic efficiency is restrained. Here, a covalent self-assembled nanomicelle (CSNM) based starburst polyprodrug was constructed with the unimolecular micelle-templated self-assembly method and was expected to overcome biol ...
DOI:
10.1021/acs.biomac.9b00424

2. Starburst Diblock Polyprodrugs: Reduction-Responsive Unimolecular Micelles with High Drug Loading and Robust Micellar Stability for Programmed Delivery of Anticancer Drugs

Author:
Ma, Xiaoqian,   et al.   ; Shi, Xiaoxiao; Hou, Meili; Bai, Shuang; Zhang, Tian; Xue, Peng; Zhang, Xiaoli; Liu, Gang; Kang, Yuejun; Xu, Zhigang;     Show all 10 Authors
Source:
Biomacromolecules 2019 v.20 no.3 pp. 1190-1202
ISSN:
1526-4602
Subject:
antineoplastic agents; beta-cyclodextrin; composite polymers; disulfide bonds; drug therapy; hydrophilicity; hydrophobicity; methyl ethers; micelles; nanomedicine; neoplasms; polymerization; tissues; water solubility
Abstract:
... Polymeric prodrug based on therapeutic nanomedicine has demonstrated great promise for effective tumor growth inhibition, however, the drawbacks of low drug-loading and weak micellar stability limit its application for clinical cancer therapy. Herein, a reduction-responsive starburst block copolymer prodrug CCP [β-cyclodextrin (β-CD)-PCPTXX-POEGMA, XX: SS or CC] has been developed for cancer thera ...
DOI:
10.1021/acs.biomac.8b01566