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- He, Chuanxin, et al. Show all 6 Authors
- Biomacromolecules 2018 v.19 no.6 pp. 1990-1998
- micelles; palmitates; aqueous solutions; hydroxyl radicals; intravenous injection; moieties; neoplasms; hydrogen peroxide; polyethylene glycol; neoplasm cells; polyglutamic acid; beta-cyclodextrin; composite polymers; nanoparticles; oxygen; carboxylic acids; ascorbic acid
- ... Relative to normal cells, tumor cells lack adequate capability of reactive oxygen scavenging. Thus, tumor cells can be selectively killed by increasing the concentration of reactive oxygen species in tumor tissue. In this report, we construct an integrated multifunctional polymeric nanoparticle which can selectively improve hydrogen peroxide (H₂O₂) levels in tumor tissue and convert them into more ...