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- Chai, Feng; Maton, Mickael; Degoutin, Stephanie; Vermet, Guillaume; Simon, Nicolas; Rousseaux, Christelle; Martel, Bernard; Blanchemain, Nicolas
- Biomaterials 2019 v.192 pp. 260-270
- adsorption; analgesics; animal models; beta-cyclodextrin; bioavailability; biodegradation; coatings; drug carriers; health services; hernia; high performance liquid chromatography; histology; in vivo studies; inflammation; pain; patients; pharmacokinetics; polyesters; porous media; quality of life; rats
- ... The avoidance of post-herniorrhaphy pain can be challenging for hernia repair and has the greatest impact on patient's quality of life, health care utilisation and cost to society. Visceral meshes, functionalised with an efficient drug carrier system – hydroxypropyl beta-cyclodextrin polymer (polyHPβCD) coating, were developed to give a prolonged intraperitoneal analgesic drug release. We attempte ...