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- Anitua, Eduardo; Nurden, Paquita; Prado, Roberto; Nurden, Alan T.; Padilla, Sabino
- Biomaterials 2019 v.192 pp. 440-460
- angiogenesis; biocompatible materials; biodegradability; blood platelets; cornea; dose response; extracellular matrix; fibrin; growth factors; hemorrhage; hemostasis; immunomodulation; inflammation; mammals; microparticles; musculoskeletal system; patients; skin (animal); therapeutics; tissue repair
- ... The healing of vascularized mammalian tissue injuries initiate with hemostasis and clotting as part of biological defense system leading to the formation of a fibrin clot in which activated platelets are trapped to quickly stop bleeding and destroy microbials. In order to harness the therapeutic potential of biomolecules secreted by platelets and stemmed from plasma, blood deconstruction has allow ...
- Liu, Lu; Liu, Yaqin; Feng, Chun; Chang, Jiang; Fu, Runqing; Wu, Tingting; Yu, Fei; Wang, Xiaoting; Xia, Lunguo; Wu, Chengtie; Fang, Bing
- Biomaterials 2019 v.192 pp. 523-536
- angiogenesis; biocompatible materials; blood vessels; bone marrow; ceramics; endothelial cells; exosomes; gene expression regulation; genes; glass; mesenchymal stromal cells; microRNA; models; secretion; signal transduction; transcription factor NF-kappa B
- ... The chemical signals of biomaterials could influence bone marrow stromal cells (BMSCs)-endothelial cells (ECs) communication during vascularized bone regeneration. However, the underlying mechanisms still remain unknown. Exosomes, a series of extracellular vesicles, have recently emerged as potential paracrine mediators in cell-cell communication. However, whether exosomes and exosomal microRNAs ( ...