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- Ma, Bohan; Niu, Fan; Qu, Xiaoyan; He, Wangxiao; Feng, Chao; Wang, Simeng; Ouyang, Zhenlin; Yan, Jin; Wen, Yurong; Xu, Dan; Shao, Yongping; Ma, Peter X.; Lu, Wuyuan
- Biomaterials 2019 v.204 pp. 1-12
- apoptosis; drugs; membrane permeability; mice; models; myeloid leukemia; nanocarriers; nanoparticles; peptides; protein-protein interactions; proteolysis; scaffolding proteins
- ... A major pharmacological barrier to peptide therapeutics is their susceptibility to proteolytic degradation and poor membrane permeability, which, in principle, can be overcome by nanoparticle-based delivery technologies. Proteins, by definition, are nano materials and have been clinically proven as an efficient delivery vehicle for small molecule drugs. Here we describe the design of a protein-bas ...
- Sun, Tao; Zhang, Guangping; Wang, Qingbing; Guo, Zhongyuan; Chen, Qinjun; Chen, Xinli; Lu, Yifei; Zhang, Yu; Zhang, Yujie; Guo, Qin; Gao, Xiang; Cheng, Yongzhong; Jiang, Chen
- Biomaterials 2019 v.204 pp. 46-58
- adverse effects; breast neoplasms; drug formulations; drugs; dyes; image analysis; near-infrared spectroscopy; peptides; precision medicine
- ... Real-time monitor of drug-release from drug formulations in a noninvasive way can provide spatio-temporal information for drug activation and guide further clinical rational administration. In this work, a molecular shuttle, as a typical nanosized artificial molecular machine, was managed to act as a conceptually-new nanotheranostics for oxaliplatin. A post-recognition strategy was utilized, where ...