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1. Bacteria-like mesoporous silica-coated gold nanorods for positron emission tomography and photoacoustic imaging-guided chemo-photothermal combined therapy

Author:
Xu, Cheng; Chen, Feng; Valdovinos, Hector F.; Jiang, Dawei; Goel, Shreya; Yu, Bo; Sun, Haiyan; Barnhart, Todd E.; Moon, James J.; Cai, Weibo
Source:
Biomaterials 2018 v.165 pp. 56-65
ISSN:
0142-9612
Subject:
coatings; doxorubicin; gold; mice; nanoparticles; nanorods; neoplasms; permeability; porosity; porous media; positron-emission tomography; silica; surface area; therapeutics
Abstract:
... Mesoporous silica nanoshell (MSN) coating has been demonstrated as a versatile surface modification strategy for various kinds of inorganic functional nanoparticles, such as gold nanorods (GNRs), to achieve not only improved nanoparticle stability but also concomitant drug loading capability. However, limited drug loading capacity and low tumor accumulation rate in vivo are two major challenges fo ...
DOI:
10.1016/j.biomaterials.2018.02.043

2. Hydrotalcite monolayer toward high performance synergistic dual-modal imaging and cancer therapy

Author:
Mei, Xuan; Wang, Wei; Yan, Liang; Hu, Tingting; Liang, Ruizheng; Yan, Dan; Wei, Min; Evans, David G.; Duan, Xue
Source:
Biomaterials 2018 v.165 pp. 14-24
ISSN:
0142-9612
Subject:
chlorins; fluorescence; gold; hydrotalcite; image analysis; magnetic resonance imaging; magnetism; nanogold; nanosheets; neoplasms; photosensitizing agents; synergism; therapeutics
Abstract:
... Recently, theranostic has drawn tremendous attention by virtue of the nanotechnology development and new material exploration. Herein, we reported a novel theranostic system by loading Au nanoclusters (AuNCs) and Chlorin e6 (photosensitizer, Ce6) onto the monolayer nanosheet surface of Gd-doped layered double hydroxide (Gd-LDH). The as-prepared Ce6&AuNCs/Gd-LDH exhibits a largely enhanced fluoresc ...
DOI:
10.1016/j.biomaterials.2018.02.032

3. Perfluorooctyl bromide & indocyanine green co-loaded nanoliposomes for enhanced multimodal imaging-guided phototherapy

Author:
Sheng, Danli; Liu, Tianzhi; Deng, Liming; Zhang, Liang; Li, Xuelin; Xu, Jie; Hao, Lan; Li, Pan; Ran, Haitao; Chen, Hangrong; Wang, Zhigang
Source:
Biomaterials 2018 v.165 pp. 1-13
ISSN:
0142-9612
Subject:
bromides; computed tomography; emulsions; energy transfer; fluorescence; heat shock proteins; hypoxia; image analysis; intravenous injection; neoplasms; oxygen; perfluorocarbons; phototherapy
Abstract:
... As a highly biocompatible NIR dye, indocyanine green (ICG) has been widely explored for cancer treatment due to its various energy level transition pathways upon NIR light excitation simultaneously, which leads to different theranostic effects (eg. Photoacoustic (PA) and fluorescence imaging (FL), photodynamic and photothermal therapy (PDT&PTT)). However, the theranostic efficiency of ICG is restr ...
DOI:
10.1016/j.biomaterials.2018.02.041