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- Maitz, Manfred F.; Zitzmann, Jan; Hanke, Jasmin; Renneberg, Claudia; Tsurkan, Mikhail V.; Sperling, Claudia; Freudenberg, Uwe; Werner, Carsten
- Biomaterials 2017 v.135 pp. 53-61
- anticoagulants; biocompatible materials; blood coagulation; coagulation; crosslinking; ethylene glycol; heparin; humans; hydrogels; polyethylene glycol; proteolysis; thrombin
- ... Feedback-controlled anticoagulant hydrogels were formed by crosslinking the anticoagulant heparin with star-shaped poly(ethylene glycol) using peptide linkers, which are selectively cleaved by different activated blood coagulation factors acting as proteolytic enzymes. Various cleavable peptide units, differing either in their thrombin turnover rates or in their responsiveness to factors activated ...
- Briquez, Priscilla S.; Lorentz, Kristen M.; Larsson, Hans M.; Frey, Peter; Hubbell, Jeffrey A.
- Biomaterials 2017 v.135 pp. 1-9
- biocompatible materials; cattle; coagulation; engineering; extracellular matrix; fibrin; fibrinolysis; humans; hypersensitivity; immune response; longevity; patients; protein-glutamine gamma-glutamyltransferase; proteinase inhibitors; sealants; sequence homology; serine proteinases
- ... Aprotinin is a broad-spectrum serine protease inhibitor used in the clinic as an anti-fibrinolytic agent in fibrin-based tissue sealants. However, upon re-exposure, some patients suffer from hypersensitivity immune reactions likely related to the bovine origin of aprotinin. Here, we aimed to develop a human-derived substitute to aprotinin. Based on sequence homology analyses, we identified the Kun ...
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