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- Briquez, Priscilla S.; Lorentz, Kristen M.; Larsson, Hans M.; Frey, Peter; Hubbell, Jeffrey A.
- Biomaterials 2017 v.135 pp. 1-9
- biocompatible materials; cattle; coagulation; engineering; extracellular matrix; fibrin; fibrinolysis; humans; hypersensitivity; immune response; longevity; patients; protein-glutamine gamma-glutamyltransferase; proteinase inhibitors; sealants; sequence homology; serine proteinases
- ... Aprotinin is a broad-spectrum serine protease inhibitor used in the clinic as an anti-fibrinolytic agent in fibrin-based tissue sealants. However, upon re-exposure, some patients suffer from hypersensitivity immune reactions likely related to the bovine origin of aprotinin. Here, we aimed to develop a human-derived substitute to aprotinin. Based on sequence homology analyses, we identified the Kun ...
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