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You searched for: Journal Biomaterials Remove constraint Journal: Biomaterials Publication Year 2016 Remove constraint Publication Year: 2016 Source 2016 v.103 Remove constraint Source: 2016 v.103
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1. A multifunctional DNA origami as carrier of metal complexes to achieve enhanced tumoral delivery and nullified systemic toxicity

Author:
Huang, Yanyu; Huang, Wei; Chan, Leung; Zhou, Binwei; Chen, Tianfeng
Source:
Biomaterials 2016 v.103 pp. 183-196
ISSN:
0142-9612
Subject:
DNA; antineoplastic activity; apoptosis; biotin; cages; cell nucleus; cytotoxicity; deoxyribonucleases; drugs; heart; human cell lines; kidneys; liver; mice; models; nanocarriers; neoplasms; ruthenium
Abstract:
... The use of metal complexes in cancer treatment is hampered by the insufficient accumulation in tumor regions and observable systemic toxicity due to their nonspecificity in vivo. Herein we present a cancer-targeted DNA origami as biocompatible nanocarrier of metal complexes to achieve advanced antitumor effect. The formation of unique tetrahedral nanostructure of DNA cages effectively enhances the ...
DOI:
10.1016/j.biomaterials.2016.06.053

2. An implantable and controlled drug-release silk fibroin nanofibrous matrix to advance the treatment of solid tumour cancers

Author:
Xie, Maobin; Fan, Dejun; Chen, Yufeng; Zhao, Zheng; He, Xiaowen; Li, Gang; Chen, Aizheng; Wu, Xiaojian; Li, Jiashen; Li, Zhi; Hunt, John A.; Li, Yi; Lan, Ping
Source:
Biomaterials 2016 v.103 pp. 33-43
ISSN:
0142-9612
Subject:
adverse effects; curcumin; drug delivery systems; drug therapy; drugs; fibroins; growth retardation; interphase; nanofibers; neoplasms; silk; tissues; toxicity
Abstract:
... The development of more effective cancer therapeutic strategies are still critically required. The maximization of the therapeutic effect in combination with avoiding the severe side effects on normal tissues when using chemotherapy drugs is still an urgent problem that requires improvements urgently. Here we provide implantable and controllable drug-release that utilises silk fibroin (SF) as a na ...
DOI:
10.1016/j.biomaterials.2016.06.049

3. Approximating bone ECM: Crosslinking directs individual and coupled osteoblast/osteoclast behavior

Author:
Hwang, Mintai P.; Subbiah, Ramesh; Kim, In Gul; Lee, Kyung Eun; Park, Jimin; Kim, Sang Heon; Park, Kwideok
Source:
Biomaterials 2016 v.103 pp. 22-32
ISSN:
0142-9612
Subject:
biocompatibility; crosslinking; elastin; osteoblasts; osteoclasts; roughness; topography
Abstract:
... Osteoblast and osteoclast communication (i.e. osteocoupling) is an intricate process, in which the biophysical profile of bone ECM is an aggregate product of their activities. While the effect of microenvironmental cues on osteoblast and osteoclast maturation has been resolved into individual variables (e.g. stiffness or topography), a single cue can be limited with regards to reflecting the full ...
DOI:
10.1016/j.biomaterials.2016.06.052

4. Balancing stealth and echogenic properties in an ultrasound contrast agent with drug delivery potential

Author:
Jablonowski, Lauren J.; Alfego, David; Andorko, James I.; Eisenbrey, John R.; Teraphongphom, Nutte; Wheatley, Margaret A.
Source:
Biomaterials 2016 v.103 pp. 197-206
ISSN:
0142-9612
Subject:
acoustics; chemical bonding; composite polymers; dose response; drugs; image analysis; lipids; microbubbles; neoplasms; physical properties; polyethylene glycol; polylactic acid; ultrasonics
Abstract:
... Contrast agents are currently being modified to combine diagnostic and therapeutic capabilities. For ultrasound (US) imaging with polymeric contrast agents, it is necessary to modify the shell to create “stealth” microbubbles but without these modifications sacrificing the agent's ability to interact with the focused US beam. We hypothesize that addition of the classic immune shielding molecule po ...
DOI:
10.1016/j.biomaterials.2016.06.036

5. Biomimetic cardiovascular stents for in vivo re-endothelialization

Author:
Liang, Chunyong; Hu, Yuecheng; Wang, Hongshui; Xia, Dan; Li, Qiang; Zhang, Jiao; Yang, Jianjun; Li, Baoe; Li, Haipeng; Han, Dong; Dong, Mingdong
Source:
Biomaterials 2016 v.103 pp. 170-182
ISSN:
0142-9612
Subject:
adhesion; biomimetics; human umbilical vein endothelial cells; iliac artery; immigration; rabbits; smooth muscle
Abstract:
... The use of cardiovascular stents for rapid in vivo re-endothelialization is a promising strategy for reducing cardiovascular implantation or preventing local thrombus formation and restenosis. Surface-patterned intravascular endoprosthetic stents have been developed to prevent life-threatening complications. In this study, vascular smooth muscle cell (VSMC)-biomimetic surface patterns were fabrica ...
DOI:
10.1016/j.biomaterials.2016.06.042

6. Cathepsin S-cleavable, multi-block HPMA copolymers for improved SPECT/CT imaging of pancreatic cancer

Author:
Fan, Wei; Shi, Wen; Zhang, Wenting; Jia, Yinnong; Zhou, Zhengyuan; Brusnahan, Susan K.; Garrison, Jered C.
Source:
Biomaterials 2016 v.103 pp. 101-115
ISSN:
0142-9612
Subject:
adenocarcinoma; blood serum; cathepsin S; composite polymers; energy transfer; ethylene glycol; flow cytometry; image analysis; macrophages; nanomedicine; pancreatic neoplasms; polymerization; tissues
Abstract:
... This work continues our efforts to improve the diagnostic and radiotherapeutic effectiveness of nanomedicine platforms by developing approaches to reduce the non-target accumulation of these agents. Herein, we developed multi-block HPMA copolymers with backbones that are susceptible to cleavage by cathepsin S, a protease that is abundantly expressed in tissues of the mononuclear phagocyte system ( ...
DOI:
10.1016/j.biomaterials.2016.05.036
PubMed:
27372424
PubMed Central:
PMC5018995

7. Cyclopamine disrupts tumor extracellular matrix and improves the distribution and efficacy of nanotherapeutics in pancreatic cancer

Author:
Zhang, Bo; Jiang, Ting; Shen, Shun; She, Xiaojian; Tuo, Yanyan; Hu, Yu; Pang, Zhiqing; Jiang, Xinguo
Source:
Biomaterials 2016 v.103 pp. 12-21
ISSN:
0142-9612
Subject:
adenocarcinoma; animal models; blood vessels; cyclopamine; extracellular matrix; fibronectins; fluorescence; growth retardation; nanomedicine; nanoparticles; pancreatic neoplasms; patients; signal transduction; therapeutics
Abstract:
... The dense extracellular matrix in pancreatic ductal adenocarcinoma dramatically reduces the penetration and efficacy of nanotherapeutics. Disruption of the tumor extracellular matrix may help improve the distribution and efficacy of nanotherapeutics in pancreatic cancer. In this study, we tested whether cyclopamine, a special inhibitor of the hedgehog signaling pathway with powerful anti-fibrotic ...
DOI:
10.1016/j.biomaterials.2016.06.048

8. Dimensionality and spreading influence MSC YAP/TAZ signaling in hydrogel environments

Author:
Caliari, Steven R.; Vega, Sebastián L.; Kwon, Michelle; Soulas, Elizabeth M.; Burdick, Jason A.
Source:
Biomaterials 2016 v.103 pp. 314-323
ISSN:
0142-9612
Subject:
actin; crosslinking; humans; hyaluronic acid; hydrocolloids; polymerization; proteolysis; stem cells
Abstract:
... Improved fundamental understanding of how cells interpret microenvironmental signals is integral to designing better biomaterial therapies. YAP/TAZ are key mediators of mechanosensitive signaling; however, it is not clear how they are regulated by the complex interplay of microenvironmental factors (e.g., stiffness and degradability) and culture dimensionality. Using covalently crosslinked norborn ...
DOI:
10.1016/j.biomaterials.2016.06.061
PubMed:
27429252
PubMed Central:
PMC4963302

9. Effect of biophysical cues on reprogramming to cardiomyocytes

Author:
Sia, Junren; Yu, Pengzhi; Srivastava, Deepak; Li, Song
Source:
Biomaterials 2016 v.103 pp. 1-11
ISSN:
0142-9612
Subject:
cardiomyocytes; fibroblasts; genes; medicine; staining; therapeutics; troponin T
Abstract:
... Reprogramming of fibroblasts to cardiomyocytes offers exciting potential in cell therapy and regenerative medicine, but has low efficiency. We hypothesize that physical cues may positively affect the reprogramming process, and studied the effects of periodic mechanical stretch, substrate stiffness and microgrooved substrate on reprogramming yield. Subjecting reprogramming fibroblasts to periodic m ...
DOI:
10.1016/j.biomaterials.2016.06.034

10. Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy

Author:
Guan, Mirong; Ge, Jiechao; Wu, Jingyi; Zhang, Guoqiang; Chen, Daiqin; Zhang, Wei; Zhang, Ying; Zou, Toujun; Zhen, Mingming; Wang, Chunru; Chu, Taiwei; Hao, Xiaojuan; Shu, Chunying
Source:
Biomaterials 2016 v.103 pp. 75-85
ISSN:
0142-9612
Subject:
absorption; biocompatibility; chlorins; ethylene glycol; fullerene; image analysis; neoplasms; therapeutics
Abstract:
... A novel phototheranostic platform based on tri-malonate derivative of fullerene C70 (TFC70)/photosensitizer (Chlorin e6, Ce6) nanovesicles (FCNVs) has been developed for effective tumor imaging and treatment. The FCNVs were prepared from amphiphilic TFC70-oligo ethylene glycol -Ce6 molecules. The developed FCNVs possessed the following advantages: (i) high loading efficiency of Ce6 (up to ∼57 wt%) ...
DOI:
10.1016/j.biomaterials.2016.06.023

11. Functional long circulating single walled carbon nanotubes for fluorescent/photoacoustic imaging-guided enhanced phototherapy

Author:
Xie, Lisi; Wang, Guohao; Zhou, Hao; Zhang, Fan; Guo, Zhide; Liu, Chuan; Zhang, Xianzhong; Zhu, Lei
Source:
Biomaterials 2016 v.103 pp. 219-228
ISSN:
0142-9612
Subject:
albumins; carbon; carbon nanotubes; chlorins; fluorescence; image analysis; intravenous injection; neoplasms; phototherapy
Abstract:
... Nanotherapeutics have been investigated for years, but only modest survival benefits were observed clinic. This is partially attributed to the short and rapid elimination of nanodrug after intravenous administration. In this study, a long circulation single wall carbon nanotube (SWCNT) complex was successfully fabricated through a new SWCNT dispersion agent, evans blue (EB). The complex was endowe ...
DOI:
10.1016/j.biomaterials.2016.06.058

12. HB-EGF embedded in PGA/PLLA scaffolds via subcritical CO2 augments the production of tissue engineered intestine

Author:
Liu, Yanchun; Nelson, Tyler; Cromeens, Barrett; Rager, Terrence; Lannutti, John; Johnson, Jed; Besner, Gail E.
Source:
Biomaterials 2016 v.103 pp. 150-159
ISSN:
0142-9612
Subject:
dissolved carbon dioxide; polymers; proteins; tissue repair; staining; intestines; scanning electron microscopy; patients; digestive system diseases; tissue engineering; growth factors; half life; foaming
Abstract:
... The ability to deliver sustained-release, biologically active growth factors through custom designed tissue engineering scaffolds at sites of tissue regeneration offers great therapeutic opportunity. Due to the short in vivo half-lives of most growth factors, it is challenging to deliver these proteins to sites of interest where they may be used before being degraded. The application of subcritica ...
DOI:
10.1016/j.biomaterials.2016.06.039

13. Hybrid anisotropic nanostructures for dual-modal cancer imaging and image-guided chemo-thermo therapies

Author:
Zhang, Ruiping; Cheng, Kai; Antaris, Alexander L.; Ma, Xiaowei; Yang, Min; Ramakrishnan, Sindhuja; Liu, Guifeng; Lu, Alex; Dai, Hongjie; Tian, Mei; Cheng, Zhen
Source:
Biomaterials 2016 v.103 pp. 265-277
ISSN:
0142-9612
Subject:
colon; drug therapy; hybrids; image analysis; magnetic resonance imaging; mice; nanoparticles; neoplasms; thermotherapy
Abstract:
... The multimodality theranostic system, which can integrate two or more different therapeutic modalities and multimodal imaging agents into a nanoentity, shows great promising prospects for the cancer treatment. Herein, we developed an efficient and novel strategy to synthesize hybrid anisotropic nanoparticles (HANs) with intrinsic multimodal theranostic capability [chemotherapy, photothermal therap ...
DOI:
10.1016/j.biomaterials.2016.06.063
PubMed:
27394161
PubMed Central:
PMC4970737

14. In situ diselenide-crosslinked polymeric micelles for ROS-mediated anticancer drug delivery

Author:
Deepagan, V.G.; Kwon, Seunglee; You, Dong Gil; Nguyen, Van Quy; Um, Wooram; Ko, Hyewon; Lee, Hansang; Jo, Dong-Gyu; Kang, Young Mo; Park, Jae Hyung
Source:
Biomaterials 2016 v.103 pp. 56-66
ISSN:
0142-9612
Subject:
antineoplastic agents; composite polymers; crosslinking; drug carriers; hydrophilicity; hydrophobicity; mice; micelles; neoplasms; polyethylene glycol; polypeptides
Abstract:
... Stimuli-responsive micelles have emerged as the drug carrier for cancer therapy since they can exclusively release the drug via their structural changes in response to the specific stimuli of the target site. Herein, we developed the in situ diselenide-crosslinked micelles (DCMs), which are responsive to the abnormal ROS levels of tumoral region, as anticancer drug carriers. The DCMs were spontane ...
DOI:
10.1016/j.biomaterials.2016.06.044

15. Installing an additional emission quenching pathway in the design of iridium(III)-based phosphorogenic biomaterials for bioorthogonal labelling and imaging

Author:
Li, Steve Po-Yam; Yip, Alex Man-Hei; Liu, Hua-Wei; Lo, Kenneth Kam-Wing
Source:
Biomaterials 2016 v.103 pp. 305-313
ISSN:
0142-9612
Subject:
biocompatible materials; bovine serum albumin; electrochemistry; electron transfer; energy transfer; image analysis; iridium; labeling techniques; luminescence; polysaccharides
Abstract:
... We report the synthesis, characterization, photophysical and electrochemical behaviour and biological labelling applications of new phosphorogenic bioorthogonal probes derived from iridium(III) polypyridine complexes containing a 1,2,4,5-tetrazine moiety. In contrast to common luminescent cyclometallated iridium(III) polypyridine complexes, these tetrazine complexes are almost non-emissive due to ...
DOI:
10.1016/j.biomaterials.2016.06.065

16. Integration of antimicrobial peptides with gold nanoparticles as unique non-viral vectors for gene delivery to mesenchymal stem cells with antibacterial activity

Author:
Peng, Li-Hua; Huang, Yan-Fen; Zhang, Chen-Zhen; Niu, Jie; Chen, Ying; Chu, Yang; Jiang, Zhi-Hong; Gao, Jian-Qing; Mao, Zheng-Wei
Source:
Biomaterials 2016 v.103 pp. 137-149
ISSN:
0142-9612
Subject:
DNA; antibacterial properties; antimicrobial peptides; gene activation; genes; medicine; nanogold; rats; stem cells; tissue repair; transfection
Abstract:
... Gold nanoparticles (AuNPs) have emerged as attractive non-viral gene vectors. However their application in regenerative medicine is still limited partially due to a lack of an intrinsic capacity to transfect difficult-to-transfect cells such as primary cells or stem cells. In current study, we report the synthesis of antimicrobial peptide conjugated cationic AuNPs (AuNPs@PEP) as highly efficient c ...
DOI:
10.1016/j.biomaterials.2016.06.057

17. In vitro screening of nanomedicines through the blood brain barrier: A critical review

Author:
Aparicio-Blanco, Juan; Martín-Sabroso, Cristina; Torres-Suárez, Ana-Isabel
Source:
Biomaterials 2016 v.103 pp. 229-255
ISSN:
0142-9612
Subject:
biocompatible materials; blood-brain barrier; brain; drug delivery systems; drugs; health services; image analysis; models; nanomedicine; screening
Abstract:
... The blood-brain barrier accounts for the high attrition rate of the treatments of most brain disorders, which therefore remain one of the greatest health-care challenges of the twenty first century. Against this background of hindrance to brain delivery, nanomedicine takes advantage of the assembly at the nanoscale of available biomaterials to provide a delivery platform with potential to raising ...
DOI:
10.1016/j.biomaterials.2016.06.051

18. Laminin-511 and laminin-521-based matrices for efficient hepatic specification of human pluripotent stem cells

Author:
Kanninen, Liisa K.; Harjumäki, Riina; Peltoniemi, Pasi; Bogacheva, Mariia S.; Salmi, Tuuli; Porola, Pauliina; Niklander, Johanna; Smutný, Tomáš; Urtti, Arto; Yliperttula, Marjo L.; Lou, Yan-Ru
Source:
Biomaterials 2016 v.103 pp. 86-100
ISSN:
0142-9612
Subject:
albumins; cytochrome P-450; drugs; enzyme activity; extracellular matrix; fibronectins; gene expression regulation; glycogen; human development; humans; in vitro studies; integrins; laminin; liver; messenger RNA; pharmaceutical industry; somatic cells; stem cells
Abstract:
... Human pluripotent stem cells (hPSCs) have gained a solid foothold in basic research and drug industry as they can be used in vitro to study human development and have potential to offer limitless supply of various somatic cell types needed in drug development. Although the hepatic differentiation of hPSCs has been extensively studied, only a little attention has been paid to the role of the extrac ...
DOI:
10.1016/j.biomaterials.2016.06.054

19. Long-term biocompatibility, imaging appearance and tissue effects associated with delivery of a novel radiopaque embolization bead for image-guided therapy

Author:
Sharma, Karun V.; Bascal, Zainab; Kilpatrick, Hugh; Ashrafi, Koorosh; Willis, Sean L.; Dreher, Matthew R.; Lewis, Andrew L.
Source:
Biomaterials 2016 v.103 pp. 293-304
ISSN:
0142-9612
Subject:
histopathology; image analysis; fibrosis; intravenous injection; liver; cytotoxicity; necrosis; models; mutagenicity; swine; arteries; blood; biocompatibility; X-radiation
Abstract:
... The objective of this study was to undertake a comprehensive long-term biocompatibility and imaging assessment of a new intrinsically radiopaque bead (LC Bead LUMI™) for use in transarterial embolization. The sterilized device and its extracts were subjected to the raft of ISO10993 biocompatibility tests that demonstrated safety with respect to cytotoxicity, mutagenicity, blood contact, irritation ...
DOI:
10.1016/j.biomaterials.2016.06.064

20. Mechanisms by which acellular biologic scaffolds promote functional skeletal muscle restoration

Author:
Badylak, Stephen F.; Dziki, Jenna L.; Sicari, Brian M.; Ambrosio, Fabrisia; Boninger, Michael L.
Source:
Biomaterials 2016 v.103 pp. 128-136
ISSN:
0142-9612
Subject:
clinical trials; extracellular matrix; medicine; muscles; skeletal muscle
Abstract:
... Acellular biologic scaffolds derived from extracellular matrix have been investigated in preclinical and clinical studies as a regenerative medicine approach for volumetric muscle loss treatment. The present manuscript provides a review of previous studies supporting the use of extracellular matrix derived biologic scaffolds for the promotion of functional skeletal muscle tissue formation that is ...
DOI:
10.1016/j.biomaterials.2016.06.047