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- Author:
- Huang, Yanyu; Huang, Wei; Chan, Leung; Zhou, Binwei; Chen, Tianfeng
- Source:
- Biomaterials 2016 v.103 pp. 183-196
- ISSN:
- 0142-9612
- Subject:
- DNA; antineoplastic activity; apoptosis; biotin; cages; cell nucleus; cytotoxicity; deoxyribonucleases; drugs; heart; human cell lines; kidneys; liver; mice; models; nanocarriers; neoplasms; ruthenium
- Abstract:
- ... The use of metal complexes in cancer treatment is hampered by the insufficient accumulation in tumor regions and observable systemic toxicity due to their nonspecificity in vivo. Herein we present a cancer-targeted DNA origami as biocompatible nanocarrier of metal complexes to achieve advanced antitumor effect. The formation of unique tetrahedral nanostructure of DNA cages effectively enhances the ...
- DOI:
- 10.1016/j.biomaterials.2016.06.053
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.053
- Author:
- Xie, Maobin; Fan, Dejun; Chen, Yufeng; Zhao, Zheng; He, Xiaowen; Li, Gang; Chen, Aizheng; Wu, Xiaojian; Li, Jiashen; Li, Zhi; Hunt, John A.; Li, Yi; Lan, Ping
- Source:
- Biomaterials 2016 v.103 pp. 33-43
- ISSN:
- 0142-9612
- Subject:
- adverse effects; curcumin; drug delivery systems; drug therapy; drugs; fibroins; growth retardation; interphase; nanofibers; neoplasms; silk; tissues; toxicity
- Abstract:
- ... The development of more effective cancer therapeutic strategies are still critically required. The maximization of the therapeutic effect in combination with avoiding the severe side effects on normal tissues when using chemotherapy drugs is still an urgent problem that requires improvements urgently. Here we provide implantable and controllable drug-release that utilises silk fibroin (SF) as a na ...
- DOI:
- 10.1016/j.biomaterials.2016.06.049
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.049
- Author:
- Hwang, Mintai P.; Subbiah, Ramesh; Kim, In Gul; Lee, Kyung Eun; Park, Jimin; Kim, Sang Heon; Park, Kwideok
- Source:
- Biomaterials 2016 v.103 pp. 22-32
- ISSN:
- 0142-9612
- Subject:
- biocompatibility; crosslinking; elastin; osteoblasts; osteoclasts; roughness; topography
- Abstract:
- ... Osteoblast and osteoclast communication (i.e. osteocoupling) is an intricate process, in which the biophysical profile of bone ECM is an aggregate product of their activities. While the effect of microenvironmental cues on osteoblast and osteoclast maturation has been resolved into individual variables (e.g. stiffness or topography), a single cue can be limited with regards to reflecting the full ...
- DOI:
- 10.1016/j.biomaterials.2016.06.052
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.052
- Author:
- Jablonowski, Lauren J.; Alfego, David; Andorko, James I.; Eisenbrey, John R.; Teraphongphom, Nutte; Wheatley, Margaret A.
- Source:
- Biomaterials 2016 v.103 pp. 197-206
- ISSN:
- 0142-9612
- Subject:
- acoustics; chemical bonding; composite polymers; dose response; drugs; image analysis; lipids; microbubbles; neoplasms; physical properties; polyethylene glycol; polylactic acid; ultrasonics
- Abstract:
- ... Contrast agents are currently being modified to combine diagnostic and therapeutic capabilities. For ultrasound (US) imaging with polymeric contrast agents, it is necessary to modify the shell to create “stealth” microbubbles but without these modifications sacrificing the agent's ability to interact with the focused US beam. We hypothesize that addition of the classic immune shielding molecule po ...
- DOI:
- 10.1016/j.biomaterials.2016.06.036
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.036
- Author:
- Liang, Chunyong; Hu, Yuecheng; Wang, Hongshui; Xia, Dan; Li, Qiang; Zhang, Jiao; Yang, Jianjun; Li, Baoe; Li, Haipeng; Han, Dong; Dong, Mingdong
- Source:
- Biomaterials 2016 v.103 pp. 170-182
- ISSN:
- 0142-9612
- Subject:
- adhesion; biomimetics; human umbilical vein endothelial cells; iliac artery; immigration; rabbits; smooth muscle
- Abstract:
- ... The use of cardiovascular stents for rapid in vivo re-endothelialization is a promising strategy for reducing cardiovascular implantation or preventing local thrombus formation and restenosis. Surface-patterned intravascular endoprosthetic stents have been developed to prevent life-threatening complications. In this study, vascular smooth muscle cell (VSMC)-biomimetic surface patterns were fabrica ...
- DOI:
- 10.1016/j.biomaterials.2016.06.042
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.042
- Author:
- Fan, Wei; Shi, Wen; Zhang, Wenting; Jia, Yinnong; Zhou, Zhengyuan; Brusnahan, Susan K.; Garrison, Jered C.
- Source:
- Biomaterials 2016 v.103 pp. 101-115
- ISSN:
- 0142-9612
- Subject:
- adenocarcinoma; blood serum; cathepsin S; composite polymers; energy transfer; ethylene glycol; flow cytometry; image analysis; macrophages; nanomedicine; pancreatic neoplasms; polymerization; tissues
- Abstract:
- ... This work continues our efforts to improve the diagnostic and radiotherapeutic effectiveness of nanomedicine platforms by developing approaches to reduce the non-target accumulation of these agents. Herein, we developed multi-block HPMA copolymers with backbones that are susceptible to cleavage by cathepsin S, a protease that is abundantly expressed in tissues of the mononuclear phagocyte system ( ...
- DOI:
- 10.1016/j.biomaterials.2016.05.036
- PubMed:
- 27372424
- PubMed Central:
- PMC5018995
-
http://dx.doi.org/10.1016/j.biomaterials.2016.05.036
- Author:
- Zhang, Bo; Jiang, Ting; Shen, Shun; She, Xiaojian; Tuo, Yanyan; Hu, Yu; Pang, Zhiqing; Jiang, Xinguo
- Source:
- Biomaterials 2016 v.103 pp. 12-21
- ISSN:
- 0142-9612
- Subject:
- adenocarcinoma; animal models; blood vessels; cyclopamine; extracellular matrix; fibronectins; fluorescence; growth retardation; nanomedicine; nanoparticles; pancreatic neoplasms; patients; signal transduction; therapeutics
- Abstract:
- ... The dense extracellular matrix in pancreatic ductal adenocarcinoma dramatically reduces the penetration and efficacy of nanotherapeutics. Disruption of the tumor extracellular matrix may help improve the distribution and efficacy of nanotherapeutics in pancreatic cancer. In this study, we tested whether cyclopamine, a special inhibitor of the hedgehog signaling pathway with powerful anti-fibrotic ...
- DOI:
- 10.1016/j.biomaterials.2016.06.048
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.048
- Author:
- Caliari, Steven R.; Vega, Sebastián L.; Kwon, Michelle; Soulas, Elizabeth M.; Burdick, Jason A.
- Source:
- Biomaterials 2016 v.103 pp. 314-323
- ISSN:
- 0142-9612
- Subject:
- actin; crosslinking; humans; hyaluronic acid; hydrocolloids; polymerization; proteolysis; stem cells
- Abstract:
- ... Improved fundamental understanding of how cells interpret microenvironmental signals is integral to designing better biomaterial therapies. YAP/TAZ are key mediators of mechanosensitive signaling; however, it is not clear how they are regulated by the complex interplay of microenvironmental factors (e.g., stiffness and degradability) and culture dimensionality. Using covalently crosslinked norborn ...
- DOI:
- 10.1016/j.biomaterials.2016.06.061
- PubMed:
- 27429252
- PubMed Central:
- PMC4963302
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.061
- Author:
- Sia, Junren; Yu, Pengzhi; Srivastava, Deepak; Li, Song
- Source:
- Biomaterials 2016 v.103 pp. 1-11
- ISSN:
- 0142-9612
- Subject:
- cardiomyocytes; fibroblasts; genes; medicine; staining; therapeutics; troponin T
- Abstract:
- ... Reprogramming of fibroblasts to cardiomyocytes offers exciting potential in cell therapy and regenerative medicine, but has low efficiency. We hypothesize that physical cues may positively affect the reprogramming process, and studied the effects of periodic mechanical stretch, substrate stiffness and microgrooved substrate on reprogramming yield. Subjecting reprogramming fibroblasts to periodic m ...
- DOI:
- 10.1016/j.biomaterials.2016.06.034
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.034
- Author:
- Guan, Mirong; Ge, Jiechao; Wu, Jingyi; Zhang, Guoqiang; Chen, Daiqin; Zhang, Wei; Zhang, Ying; Zou, Toujun; Zhen, Mingming; Wang, Chunru; Chu, Taiwei; Hao, Xiaojuan; Shu, Chunying
- Source:
- Biomaterials 2016 v.103 pp. 75-85
- ISSN:
- 0142-9612
- Subject:
- absorption; biocompatibility; chlorins; ethylene glycol; fullerene; image analysis; neoplasms; therapeutics
- Abstract:
- ... A novel phototheranostic platform based on tri-malonate derivative of fullerene C70 (TFC70)/photosensitizer (Chlorin e6, Ce6) nanovesicles (FCNVs) has been developed for effective tumor imaging and treatment. The FCNVs were prepared from amphiphilic TFC70-oligo ethylene glycol -Ce6 molecules. The developed FCNVs possessed the following advantages: (i) high loading efficiency of Ce6 (up to ∼57 wt%) ...
- DOI:
- 10.1016/j.biomaterials.2016.06.023
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.023
- Author:
- Xie, Lisi; Wang, Guohao; Zhou, Hao; Zhang, Fan; Guo, Zhide; Liu, Chuan; Zhang, Xianzhong; Zhu, Lei
- Source:
- Biomaterials 2016 v.103 pp. 219-228
- ISSN:
- 0142-9612
- Subject:
- albumins; carbon; carbon nanotubes; chlorins; fluorescence; image analysis; intravenous injection; neoplasms; phototherapy
- Abstract:
- ... Nanotherapeutics have been investigated for years, but only modest survival benefits were observed clinic. This is partially attributed to the short and rapid elimination of nanodrug after intravenous administration. In this study, a long circulation single wall carbon nanotube (SWCNT) complex was successfully fabricated through a new SWCNT dispersion agent, evans blue (EB). The complex was endowe ...
- DOI:
- 10.1016/j.biomaterials.2016.06.058
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.058
- Author:
- Liu, Yanchun; Nelson, Tyler; Cromeens, Barrett; Rager, Terrence; Lannutti, John; Johnson, Jed; Besner, Gail E.
- Source:
- Biomaterials 2016 v.103 pp. 150-159
- ISSN:
- 0142-9612
- Subject:
- dissolved carbon dioxide; polymers; proteins; tissue repair; staining; intestines; scanning electron microscopy; patients; digestive system diseases; tissue engineering; growth factors; half life; foaming
- Abstract:
- ... The ability to deliver sustained-release, biologically active growth factors through custom designed tissue engineering scaffolds at sites of tissue regeneration offers great therapeutic opportunity. Due to the short in vivo half-lives of most growth factors, it is challenging to deliver these proteins to sites of interest where they may be used before being degraded. The application of subcritica ...
- DOI:
- 10.1016/j.biomaterials.2016.06.039
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.039
- Author:
- Zhang, Ruiping; Cheng, Kai; Antaris, Alexander L.; Ma, Xiaowei; Yang, Min; Ramakrishnan, Sindhuja; Liu, Guifeng; Lu, Alex; Dai, Hongjie; Tian, Mei; Cheng, Zhen
- Source:
- Biomaterials 2016 v.103 pp. 265-277
- ISSN:
- 0142-9612
- Subject:
- colon; drug therapy; hybrids; image analysis; magnetic resonance imaging; mice; nanoparticles; neoplasms; thermotherapy
- Abstract:
- ... The multimodality theranostic system, which can integrate two or more different therapeutic modalities and multimodal imaging agents into a nanoentity, shows great promising prospects for the cancer treatment. Herein, we developed an efficient and novel strategy to synthesize hybrid anisotropic nanoparticles (HANs) with intrinsic multimodal theranostic capability [chemotherapy, photothermal therap ...
- DOI:
- 10.1016/j.biomaterials.2016.06.063
- PubMed:
- 27394161
- PubMed Central:
- PMC4970737
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.063
- Author:
- Deepagan, V.G.; Kwon, Seunglee; You, Dong Gil; Nguyen, Van Quy; Um, Wooram; Ko, Hyewon; Lee, Hansang; Jo, Dong-Gyu; Kang, Young Mo; Park, Jae Hyung
- Source:
- Biomaterials 2016 v.103 pp. 56-66
- ISSN:
- 0142-9612
- Subject:
- antineoplastic agents; composite polymers; crosslinking; drug carriers; hydrophilicity; hydrophobicity; mice; micelles; neoplasms; polyethylene glycol; polypeptides
- Abstract:
- ... Stimuli-responsive micelles have emerged as the drug carrier for cancer therapy since they can exclusively release the drug via their structural changes in response to the specific stimuli of the target site. Herein, we developed the in situ diselenide-crosslinked micelles (DCMs), which are responsive to the abnormal ROS levels of tumoral region, as anticancer drug carriers. The DCMs were spontane ...
- DOI:
- 10.1016/j.biomaterials.2016.06.044
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.044
- Author:
- Li, Steve Po-Yam; Yip, Alex Man-Hei; Liu, Hua-Wei; Lo, Kenneth Kam-Wing
- Source:
- Biomaterials 2016 v.103 pp. 305-313
- ISSN:
- 0142-9612
- Subject:
- biocompatible materials; bovine serum albumin; electrochemistry; electron transfer; energy transfer; image analysis; iridium; labeling techniques; luminescence; polysaccharides
- Abstract:
- ... We report the synthesis, characterization, photophysical and electrochemical behaviour and biological labelling applications of new phosphorogenic bioorthogonal probes derived from iridium(III) polypyridine complexes containing a 1,2,4,5-tetrazine moiety. In contrast to common luminescent cyclometallated iridium(III) polypyridine complexes, these tetrazine complexes are almost non-emissive due to ...
- DOI:
- 10.1016/j.biomaterials.2016.06.065
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.065
- Author:
- Peng, Li-Hua; Huang, Yan-Fen; Zhang, Chen-Zhen; Niu, Jie; Chen, Ying; Chu, Yang; Jiang, Zhi-Hong; Gao, Jian-Qing; Mao, Zheng-Wei
- Source:
- Biomaterials 2016 v.103 pp. 137-149
- ISSN:
- 0142-9612
- Subject:
- DNA; antibacterial properties; antimicrobial peptides; gene activation; genes; medicine; nanogold; rats; stem cells; tissue repair; transfection
- Abstract:
- ... Gold nanoparticles (AuNPs) have emerged as attractive non-viral gene vectors. However their application in regenerative medicine is still limited partially due to a lack of an intrinsic capacity to transfect difficult-to-transfect cells such as primary cells or stem cells. In current study, we report the synthesis of antimicrobial peptide conjugated cationic AuNPs (AuNPs@PEP) as highly efficient c ...
- DOI:
- 10.1016/j.biomaterials.2016.06.057
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.057
- Author:
- Aparicio-Blanco, Juan; Martín-Sabroso, Cristina; Torres-Suárez, Ana-Isabel
- Source:
- Biomaterials 2016 v.103 pp. 229-255
- ISSN:
- 0142-9612
- Subject:
- biocompatible materials; blood-brain barrier; brain; drug delivery systems; drugs; health services; image analysis; models; nanomedicine; screening
- Abstract:
- ... The blood-brain barrier accounts for the high attrition rate of the treatments of most brain disorders, which therefore remain one of the greatest health-care challenges of the twenty first century. Against this background of hindrance to brain delivery, nanomedicine takes advantage of the assembly at the nanoscale of available biomaterials to provide a delivery platform with potential to raising ...
- DOI:
- 10.1016/j.biomaterials.2016.06.051
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.051
- Author:
- Kanninen, Liisa K.; Harjumäki, Riina; Peltoniemi, Pasi; Bogacheva, Mariia S.; Salmi, Tuuli; Porola, Pauliina; Niklander, Johanna; Smutný, Tomáš; Urtti, Arto; Yliperttula, Marjo L.; Lou, Yan-Ru
- Source:
- Biomaterials 2016 v.103 pp. 86-100
- ISSN:
- 0142-9612
- Subject:
- albumins; cytochrome P-450; drugs; enzyme activity; extracellular matrix; fibronectins; gene expression regulation; glycogen; human development; humans; in vitro studies; integrins; laminin; liver; messenger RNA; pharmaceutical industry; somatic cells; stem cells
- Abstract:
- ... Human pluripotent stem cells (hPSCs) have gained a solid foothold in basic research and drug industry as they can be used in vitro to study human development and have potential to offer limitless supply of various somatic cell types needed in drug development. Although the hepatic differentiation of hPSCs has been extensively studied, only a little attention has been paid to the role of the extrac ...
- DOI:
- 10.1016/j.biomaterials.2016.06.054
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.054
- Author:
- Sharma, Karun V.; Bascal, Zainab; Kilpatrick, Hugh; Ashrafi, Koorosh; Willis, Sean L.; Dreher, Matthew R.; Lewis, Andrew L.
- Source:
- Biomaterials 2016 v.103 pp. 293-304
- ISSN:
- 0142-9612
- Subject:
- histopathology; image analysis; fibrosis; intravenous injection; liver; cytotoxicity; necrosis; models; mutagenicity; swine; arteries; blood; biocompatibility; X-radiation
- Abstract:
- ... The objective of this study was to undertake a comprehensive long-term biocompatibility and imaging assessment of a new intrinsically radiopaque bead (LC Bead LUMI™) for use in transarterial embolization. The sterilized device and its extracts were subjected to the raft of ISO10993 biocompatibility tests that demonstrated safety with respect to cytotoxicity, mutagenicity, blood contact, irritation ...
- DOI:
- 10.1016/j.biomaterials.2016.06.064
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.064
- Author:
- Badylak, Stephen F.; Dziki, Jenna L.; Sicari, Brian M.; Ambrosio, Fabrisia; Boninger, Michael L.
- Source:
- Biomaterials 2016 v.103 pp. 128-136
- ISSN:
- 0142-9612
- Subject:
- clinical trials; extracellular matrix; medicine; muscles; skeletal muscle
- Abstract:
- ... Acellular biologic scaffolds derived from extracellular matrix have been investigated in preclinical and clinical studies as a regenerative medicine approach for volumetric muscle loss treatment. The present manuscript provides a review of previous studies supporting the use of extracellular matrix derived biologic scaffolds for the promotion of functional skeletal muscle tissue formation that is ...
- DOI:
- 10.1016/j.biomaterials.2016.06.047
-
http://dx.doi.org/10.1016/j.biomaterials.2016.06.047