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1. Self-deploying shape memory polymer scaffolds for grafting and stabilizing complex bone defects: A mouse femoral segmental defect study

Author:
Baker, Richard M.; Tseng, Ling-Fang; Iannolo, Maria T.; Oest, Megan E.; Henderson, James H.
Source:
Biomaterials 2016 v.76 pp. 388-398
ISSN:
0142-9612
Subject:
micro-computed tomography,   etc   ; X-radiation; allografting; bone formation; fracture fixation; health services; mechanical properties; mice; models; polymers; radiography; synthetic products; United States;     Show all 13 Subjects
Abstract:
... Treatment of complex bone defects places a significant burden on the US health care system. Current strategies for treatment include grafting and stabilization using internal metal plates/screws, intramedullary rods, or external fixators. Here, we introduce the use of shape memory polymer (SMP) materials for grafting and adjunct stabilization of segmental defects. Self-deploying SMP grafts and SMP ...
DOI:
10.1016/j.biomaterials.2015.10.064

2. Influence of sulfur content on bone formation and antibacterial ability of sulfonated PEEK

Author:
Ouyang, Liping; Zhao, Yaochao; Jin, Guodong; Lu, Tao; Li, Jinhua; Qiao, Yuqin; Ning, Congqin; Zhang, Xianlong; Chu, Paul K.; Liu, Xuanyong
Source:
Biomaterials 2016 v.83 pp. 115-126
ISSN:
0142-9612
Subject:
micro-computed tomography,   etc   ; Escherichia coli; Staphylococcus aureus; X-radiation; bacteria; bone formation; cell proliferation; femur; hot water treatment; mechanical properties; models; orthopedics; quantitative polymerase chain reaction; rats; stem cells; sulfur; sulfuric acid; temperature;     Show all 18 Subjects
Abstract:
... Polyetheretherketone (PEEK) is desirable in orthopedic and dental applications because its mechanical properties are similar to those of natural bones but the bioinertness and inferior osteoconduction of PEEK have hampered many clinical applications. In this work, PEEK is sulfonated by concentrated sulfuric acid to fabricate a three-dimensional (3D) network. A hydrothermal treatment is subsequentl ...
DOI:
10.1016/j.biomaterials.2016.01.017

3. Synthesis and comparative evaluation of novel 64Cu-labeled high affinity cell-specific peptides for positron emission tomography imaging of tumor vasculature

Author:
Merrill, Joseph R.; Krajewski, Krzysztof; Yuan, Hong; Frank, Jonathan E.; Lalush, David S.; Patterson, Cam; Veleva, Anka N.
Source:
Biomaterials 2016 v.84 pp. 241-249
ISSN:
0142-9612
Subject:
computed tomography,   etc   ; absorbed dose; angiogenesis; bacteriophages; blood; humans; image analysis; lung neoplasms; models; peptide libraries; positron-emission tomography; rodents; screening; subcutaneous injection;     Show all 14 Subjects
Abstract:
... Tumor angiogenesis, the formation of new tumor blood supply, has been recognized as a hallmark of cancer and represents an important target for clinical management of various angiogenesis-dependent solid tumors. Previously, by screening a bacteriophage peptide library we have discovered the FHT-peptide sequence that binds specifically to bone marrow-derived tumor vasculature with high affinity. He ...
DOI:
10.1016/j.biomaterials.2016.01.031

4. Aligned nanofibrillar collagen scaffolds – Guiding lymphangiogenesis for treatment of acquired lymphedema

Author:
Hadamitzky, Catarina; Zaitseva, Tatiana S.; Bazalova-Carter, Magdalena; Paukshto, Michael V.; Hou, Luqia; Strassberg, Zachary; Ferguson, James; Matsuura, Yuka; Dash, Rajesh; Yang, Phillip C.; Kretchetov, Shura; Vogt, Peter M.; Rockson, Stanley G.; Cooke, John P.; Huang, Ngan F.
Source:
Biomaterials 2016 v.102 pp. 259-267
ISSN:
0142-9612
Subject:
computed tomography,   etc   ; bioelectrical impedance; collagen; collectors; fluorescent antibody technique; lymph nodes; models; staining; swine; vascular endothelial growth factor C;     Show all 10 Subjects
Abstract:
... Secondary lymphedema is a common disorder associated with acquired functional impairment of the lymphatic system. The goal of this study was to evaluate the therapeutic efficacy of aligned nanofibrillar collagen scaffolds (BioBridge) positioned across the area of lymphatic obstruction in guiding lymphatic regeneration. In a porcine model of acquired lymphedema, animals were treated with BioBridge ...
DOI:
10.1016/j.biomaterials.2016.05.040
PubMed:
27348849
PubMed Central:
PMC5157930

5. Dental cell sheet biomimetic tooth bud model

Author:
Monteiro, Nelson; Smith, Elizabeth E.; Angstadt, Shantel; Zhang, Weibo; Khademhosseini, Ali; Yelick, Pamela C.
Source:
Biomaterials 2016 v.106 pp. 167-179
ISSN:
0142-9612
Subject:
micro-computed tomography,   etc   ; biomimetics; cell differentiation; dentistry; enamel; epithelium; humans; hydrocolloids; immunohistochemistry; in vitro culture; microscopy; mineralization; models; polarized light; pulp; staining; teeth; tissue engineering;     Show all 18 Subjects
Abstract:
... Tissue engineering and regenerative medicine technologies offer promising therapies for both medicine and dentistry. Our long-term goal is to create functional biomimetic tooth buds for eventual tooth replacement in humans. Here, our objective was to create a biomimetic 3D tooth bud model consisting of dental epithelial (DE) – dental mesenchymal (DM) cell sheets (CSs) combined with biomimetic enam ...
DOI:
10.1016/j.biomaterials.2016.08.024
PubMed:
27565550
PubMed Central:
PMC5025039

6. Functional regeneration of ligament-bone interface using a triphasic silk-based graft

Author:
Li, Hongguo; Fan, Jiabing; Sun, Liguo; Liu, Xincheng; Cheng, Pengzhen; Fan, Hongbin
Source:
Biomaterials 2016 v.106 pp. 180-192
ISSN:
0142-9612
Subject:
micro-computed tomography,   etc   ; anterior cruciate ligament; biocompatibility; biodegradability; bone marrow; cartilage; chondrocytes; coatings; mechanical properties; models; osteoblasts; rabbits; silk; stem cells; therapeutics;     Show all 15 Subjects
Abstract:
... The biodegradable silk-based scaffold with unique mechanical property and biocompatibility represents a favorable ligamentous graft for tissue-engineering anterior cruciate ligament (ACL) reconstruction. However, the low efficiency of ligament-bone interface restoration barriers the isotropic silk graft to common ACL therapeutics. To enhance the regeneration of the silk-mediated interface, we deve ...
DOI:
10.1016/j.biomaterials.2016.08.012