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You searched for: Journal Biomaterials Remove constraint Journal: Biomaterials Publication Year 2014 Remove constraint Publication Year: 2014 Source 2014 v.35 Remove constraint Source: 2014 v.35
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1. A novel Bruch's membrane-mimetic electrospun substrate scaffold for human retinal pigment epithelium cells

Author:
Xiang, Ping; Wu, Kun-Chao; Zhu, Ying; Xiang, Lue; Li, Chong; Chen, Deng-Long; Chen, Feng; Xu, Guotong; Wang, Aijun; Li, Min; Jin, Zi-Bing
Source:
Biomaterials 2014 v.35 pp. 9777-9788
ISSN:
0142-9612
Subject:
Antheraea pernyi; artificial membranes; biocompatibility; cell growth; cell viability; coculture; epithelium; fibroins; gelatin; genes; humans; inflammation; microvilli; nanofibers; porosity; prostheses; silk; swine
Abstract:
... Various artificial membranes have been used as scaffolds for retinal pigment epithelium cells (RPE) for monolayer reconstruction, however, long-term cell viability and functionality are still largely unknown. This study aimed to construct an ultrathin porous nanofibrous film to mimic Bruch's membrane, and in particular to investigate human RPE cell responses to the resultant substrates. An ultrath ...
DOI:
10.1016/j.biomaterials.2014.08.040

2. A platform technique for growth factor delivery with novel mode of action

Author:
Kim, Nam Hee; Cha, Yong Hoon; Kim, Hyun Sil; Lee, Soo Eon; Huh, Jong-Ki; Kim, Jung Kook; Kim, Jeong Moon; Ryu, Joo Kyung; Kim, Hee-Jin; Lee, Yoonmi; Lee, Su Yeon; Noh, Insup; Li, Xiao-Yan; Weiss, Stephen J.; Jahng, Tae-Ahn; Yook, Jong In
Source:
Biomaterials 2014 v.35 pp. 9888-9896
ISSN:
0142-9612
Subject:
adverse effects; mechanism of action; pharmacokinetics; polypeptides; proteolysis; secretion; therapeutics; tissue repair; transforming growth factor beta
Abstract:
... Though growth factors allow tissue regeneration, the trade-off between their effectiveness and adverse effects limits clinical application. The key issues in current growth factor therapy largely derive from initial burst pharmacokinetics, rapid clearance, and proteolytic cleavage resulting in clinical ineffectiveness and diverse complications. While a number of studies have focused on the develop ...
DOI:
10.1016/j.biomaterials.2014.08.005

3. A self-assembled polymeric micellar immunomodulator for cancer treatment based on cationic amphiphilic polymers

Author:
Yim, Hyeona; Park, Wooram; Kim, Dongin; Fahmy, Tarek M.; Na, Kun
Source:
Biomaterials 2014 v.35 pp. 9912-9919
ISSN:
0142-9612
Subject:
antineoplastic activity; cisplatin; drug resistance; hyaluronic acid; hydrophilicity; hydrophobicity; immune response; immunomodulators; mice; micelles; necrosis; neoplasms; particle size; polymers; retinoic acid; synergism; toxicity
Abstract:
... Here, we report a self-assembled polymeric micellar immunomodulator (SPI) for enhanced cancer treatment based on cationic amphiphilic polymers. To obtain the cationic amphiphilic polymer, the hydrophobic all-trans-retinoic acid (ATRA) was conjugated with a hydrophilic low-molecular-weight PEI (LowPEI, Mn = 1.8 kDa). The ATRA–LowPEI conjugates could self-assemble in aqueous media, forming micelles ...
DOI:
10.1016/j.biomaterials.2014.08.029

4. Biocompatibility and inflammatory response in vitro and in vivo to gelatin-based biomaterials with tailorable elastic properties

Author:
Ullm, Sandra; Krüger, Anne; Tondera, Christoph; Gebauer, Tim P.; Neffe, Axel T.; Lendlein, Andreas; Jung, Friedrich; Pietzsch, Jens
Source:
Biomaterials 2014 v.35 pp. 9755-9766
ISSN:
0142-9612
Subject:
biocompatibility; biocompatible materials; cell adhesion; cytokines; endothelial cells; gelatin; granulocytes; humans; hydrogels; inflammation; lysine; macrophages; metalloproteinases; mice; prostaglandin synthase; secretion; tight junctions; tissues
Abstract:
... Hydrogels prepared from gelatin and lysine diisocyanate ethyl ester provide tailorable elastic properties and degradation behavior. Their interaction with human aortic endothelial cells (HAEC) as well as human macrophages (Mɸ) and granulocytes (Gɸ) were explored. The experiments revealed a good biocompatibility, appropriate cell adhesion, and cell infiltration. Direct contact to hydrogels, but not ...
DOI:
10.1016/j.biomaterials.2014.08.023

5. Cerium oxide nanoparticles attenuate monocrotaline induced right ventricular hypertrophy following pulmonary arterial hypertension

Author:
Kolli, Madhukar B.; Manne, Nandini D.P.K.; Para, Radhakrishna; Nalabotu, Siva K.; Nandyala, Geeta; Shokuhfar, Tolou; He, Kun; Hamlekhan, Azhang; Ma, Jane Y.; Wehner, Paulette S.; Dornon, Lucy; Arvapalli, Ravikumar; Rice, Kevin M.; Blough, Eric R.
Source:
Biomaterials 2014 v.35 pp. 9951-9962
ISSN:
0142-9612
Subject:
antioxidant activity; blood serum; body weight; cardiac output; cardiomyocytes; caspase-3; ceric oxide; echocardiography; fibronectins; heart ventricle; hypertension; hypertrophy; males; monocrotaline; nanoparticles; rats
Abstract:
... Cerium oxide (CeO2) nanoparticles have been posited to exhibit potent anti-oxidant activity which may allow for the use of these materials in biomedical applications. Herein, we investigate whether CeO2 nanoparticle administration can diminish right ventricular (RV) hypertrophy following four weeks of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). Male Sprague Dawley rats were ...
DOI:
10.1016/j.biomaterials.2014.08.037
PubMed:
25224369
PubMed Central:
PMC4758344

6. Delayed animal aging through the recovery of stem cell senescence by platelet rich plasma

Author:
Liu, Hen-Yu; Huang, Chiung-Fang; Lin, Tzu-Chieh; Tsai, Ching-Yu; Tina Chen, Szu-Yu; Liu, Alice; Chen, Wei-Hong; Wei, Hong-Jian; Wang, Ming-Fu; Williams, David F.; Deng, Win-Ping
Source:
Biomaterials 2014 v.35 pp. 9767-9776
ISSN:
0142-9612
Subject:
adipogenesis; alternative medicine; body weight; bone formation; bone marrow; cell growth; cell proliferation; cell senescence; fibroblasts; longevity; mice; oxidative stress; phenotype; stem cells; tissue repair
Abstract:
... Aging is related to loss of functional stem cell accompanying loss of tissue and organ regeneration potentials. Previously, we demonstrated that the life span of ovariectomy-senescence accelerated mice (OVX-SAMP8) was significantly prolonged and similar to that of the congenic senescence-resistant strain of mice after platelet rich plasma (PRP)/embryonic fibroblast transplantation. The aim of this ...
DOI:
10.1016/j.biomaterials.2014.08.034

7. Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

Author:
Kettenberger, Ulrike; Ston, Julien; Thein, Eric; Procter, Philip; Pioletti, Dominique P.
Source:
Biomaterials 2014 v.35 pp. 9995-10006
ISSN:
0142-9612
Subject:
bone formation; bone resorption; crosslinking; drugs; hyaluronic acid; hydrogels; micro-computed tomography; models; monitoring; ovariectomy; polymers; rats; resorption
Abstract:
... Bisphosphonates are known for their strong inhibitory effect on bone resorption. Their influence on bone formation however is less clear. In this study we investigated the spatio-temporal effect of locally delivered Zoledronate on peri-implant bone formation and resorption in an ovariectomized rat femoral model. A cross-linked hyaluronic acid hydrogel was loaded with the drug and applied bilateral ...
DOI:
10.1016/j.biomaterials.2014.09.005

8. Down-regulating ERK1/2 and SMAD2/3 phosphorylation by physical barrier of celecoxib-loaded electrospun fibrous membranes prevents tendon adhesions

Author:
Jiang, Shichao; Zhao, Xin; Chen, Shuai; Pan, Guoqing; Song, Jialin; He, Ning; Li, Fengfeng; Cui, Wenguo; Fan, Cunyi
Source:
Biomaterials 2014 v.35 pp. 9920-9929
ISSN:
0142-9612
Subject:
collagen; composite polymers; drugs; fibroblasts; inflammation; models; phosphorylation; polylactic acid; rabbits; surgery
Abstract:
... Peritendinous adhesions, as a major problem in hand surgery, may be due to the proliferation of fibroblasts and excessive collagen synthesis, in which ERK1/2 and SMAD2/3 plays crucial roles. In this study, we hypothesized that the complication progression could be inhibited by down-regulating ERK1/2 and SMAD2/3 phosphorylation of exogenous fibroblasts with celecoxib. Celecoxib was incorporated in ...
DOI:
10.1016/j.biomaterials.2014.08.028

9. Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets

Author:
Zhou, Teng; Zhang, Bo; Wei, Peng; Du, Yipeng; Zhou, Hejiang; Yu, Meifang; Yan, Liang; Zhang, Wendi; Nie, Guangjun; Chen, Chunying; Tu, Yaping; Wei, Taotao
Source:
Biomaterials 2014 v.35 pp. 9833-9843
ISSN:
0142-9612
Subject:
actin; adenosine triphosphate; amino acids; biocompatibility; breast neoplasms; cell culture; cell movement; cytoskeleton; energy; graphene oxide; isotope labeling; metastasis; mitochondria; nanomedicine; nanosheets; neoplasm cells; oxidative phosphorylation; patients; phenotype; polyethylene glycol; protein synthesis; stable isotopes; viability
Abstract:
... Recent advances in nanomedicine provide promising alternatives for cancer treatment that may improve the survival of patients with metastatic disease. The goal of the present study was to evaluate graphene oxide (GO) as a potential anti-metastatic agent. For this purpose, GO was modified with polyethylene glycol (PEG) to form PEG-modified GO (PEG-GO), which improves its aqueous stability and bioco ...
DOI:
10.1016/j.biomaterials.2014.08.033

10. Enhanced effect of pH-sensitive mixed copolymer micelles for overcoming multidrug resistance of doxorubicin

Author:
Qiu, Lipeng; Qiao, Mingxi; Chen, Qing; Tian, Chenmin; Long, Miaomiao; Wang, Mingyue; Li, Zhen; Hu, Wen; Li, Gang; Cheng, Liang; Cheng, Lifang; Hu, Haiyang; Zhao, Xiuli; Chen, Dawei
Source:
Biomaterials 2014 v.35 pp. 9877-9887
ISSN:
0142-9612
Subject:
P-glycoproteins; adenosine triphosphate; breast neoplasms; composite polymers; cytotoxicity; doxorubicin; histidine; in vivo studies; membrane potential; mice; micelles; mitochondrial membrane; multiple drug resistance; neoplasm cells; pH; polyethylene glycol
Abstract:
... P-glycoprotein (P-gp) mediated drug efflux has been recognized as a key factor contributing to the multidrug resistance (MDR) in tumor cells. To address this issue, a new pH-sensitive mixed copolymer micelles system composed of hyaluronic acid-g-poly(l-histidine) (HA-PHis) and d-α-tocopheryl polyethylene glycol 2000 (TPGS2k) copolymers was developed to co-deliver doxorubicin (DOX) and TPGS2k into ...
DOI:
10.1016/j.biomaterials.2014.08.008

11. High-content imaging and gene expression analysis to study cell–nanomaterial interactions: The effect of surface hydrophobicity

Author:
Manshian, Bella B.; Moyano, Daniel F.; Corthout, Nikky; Munck, Sebastian; Himmelreich, Uwe; Rotello, Vincent M.; Soenen, Stefaan J.
Source:
Biomaterials 2014 v.35 pp. 9941-9950
ISSN:
0142-9612
Subject:
autophagy; cell cycle; cell viability; cultured cells; gene expression; hydrophobicity; image analysis; mitochondria; nanogold; nanoparticles; statistical analysis
Abstract:
... The effects of nanoparticle (NP)-related parameters on cellular interactions are currently uncertain as analysis is complicated by the combinatorial diversity arising from the array of size, shape and surface properties. Here, we present a validated multiparametric high-content imaging method, with the utility of this approach demonstrated by in-depth analysis of the role of hydrophobicity on the ...
DOI:
10.1016/j.biomaterials.2014.08.031

12. Immunostimulatory oligonucleotides-loaded cationic graphene oxide with photothermally enhanced immunogenicity for photothermal/immune cancer therapy

Author:
Tao, Yu; Ju, Enguo; Ren, Jinsong; Qu, Xiaogang
Source:
Biomaterials 2014 v.35 pp. 9963-9971
ISSN:
0142-9612
Subject:
absorbance; cytokines; graphene oxide; heat; immune response; immunostimulants; irradiation; mechanical properties; nanocarriers; neoplasms; physiological transport; polyethylene glycol; polyethyleneimine
Abstract:
... Graphene oxide (GO) has attracted tremendous research interest due to its excellent electrical, thermal, and mechanical properties. Here, we apply the polyethylene glycol (PEG) and polyethylenimine (PEI) dual-polymer-functionalized GO (GO-PEG-PEI) as the carrier for efficient CpG delivery. GO-PEG-PEI can significantly promote the production of proinflammatory cytokines and enhance the immunostimul ...
DOI:
10.1016/j.biomaterials.2014.08.036

13. Improved implant osseointegration of a nanostructured titanium surface via mediation of macrophage polarization

Author:
Ma, Qian-Li; Zhao, Ling-Zhou; Liu, Rong-Rong; Jin, Bo-Quan; Song, Wen; Wang, Ying; Zhang, Yu-Si; Chen, Li-Hua; Zhang, Yu-Mei
Source:
Biomaterials 2014 v.35 pp. 9853-9867
ISSN:
0142-9612
Subject:
adverse effects; bone formation; hydrophilicity; inflammation; macrophages; nanomaterials; titanium; titanium dioxide; ultraviolet radiation
Abstract:
... The use of endosseous implanted materials is often limited by undesirable effects that may be due to macrophage-related inflammation. The purpose of this study was to fabricate a nanostructured surface on a titanium implant to regulate the macrophage inflammatory response and improve the performance of the implant. Anodization at 5 and 20 V as well as UV irradiation were used to generate hydrophil ...
DOI:
10.1016/j.biomaterials.2014.08.025

14. Intra-articular administration of gelatin hydrogels incorporating rapamycin–micelles reduces the development of experimental osteoarthritis in a murine model

Author:
Matsuzaki, Tokio; Matsushita, Takehiko; Tabata, Yasuhiko; Saito, Takashi; Matsumoto, Tomoyuki; Nagai, Kanto; Kuroda, Ryosuke; Kurosaka, Masahiro
Source:
Biomaterials 2014 v.35 pp. 9904-9911
ISSN:
0142-9612
Subject:
animal models; autophagy; chondrocytes; gelatin; gene expression regulation; genes; homeostasis; hydrogels; immunohistochemistry; mice; microarray technology; osteoarthritis; patients; protective effect; quantitative polymerase chain reaction; rapamycin; surgery
Abstract:
... Autophagy is a cellular homeostasis mechanism that may have a protective role against osteoarthritis (OA). The present study investigated the therapeutic effect of local administration of rapamycin, a potent activator of autophagy, against OA. To achieve controlled intra-articular administration of rapamycin, gelatin hydrogels incorporating rapamycin-micelles were created and the release profile w ...
DOI:
10.1016/j.biomaterials.2014.08.041

15. Intra-articular delivery of kartogenin-conjugated chitosan nano/microparticles for cartilage regeneration

Author:
Kang, Mi Lan; Ko, Ji-Yun; Kim, Ji Eun; Im, Gun-Il
Source:
Biomaterials 2014 v.35 pp. 9984-9994
ISSN:
0142-9612
Subject:
bone marrow; cartilage; catalysts; chitosan; chondrocytes; drug delivery systems; gelation; humans; microparticles; models; nanoparticles; osteoarthritis; rats; stem cells; tripolyphosphates
Abstract:
... We developed an intra-articular (IA) drug delivery system to treat osteoarthritis (OA) that consisted of kartogenin conjugated chitosan (CHI-KGN). Kartogenin, which promotes the selective differentiation of mesenchymal stem cells (MSCs) into chondrocytes, was conjugated with low-molecular-weight chitosan (LMWCS) and medium-molecular-weight chitosan (MMWCS) by covalent coupling of kartogenin to eac ...
DOI:
10.1016/j.biomaterials.2014.08.042

16. Liquid-solid phase transition alloy as reversible and rapid molding bone cement

Author:
Yi, Liting; Jin, Chao; Wang, Lei; Liu, Jing
Source:
Biomaterials 2014 v.35 pp. 9789-9801
ISSN:
0142-9612
Subject:
alloys; biocompatibility; cement; image analysis; melting point; monitoring; necrosis; phase transition; plasticity; polymerization; polymethylmethacrylate; prostheses; strength (mechanics); surgery; tin; zinc
Abstract:
... Acrylic bone cement has been an essential non-metallic implant used as fixing agent in the cemented total joint arthroplasty (THA). However, the currently available materials based mainly on polymethylmethacrylate (PMMA) still encounter certain limitations, such as time-consuming polymerization, thermal and chemical necrosis and troublesome revision procedure. Here from an alternative way, we prop ...
DOI:
10.1016/j.biomaterials.2014.08.048

17. Micro-patterned cell-sheets fabricated with stamping-force-controlled micro-contact printing

Author:
Tanaka, Nobuyuki; Ota, Hiroki; Fukumori, Kazuhiro; Miyake, Jun; Yamato, Masayuki; Okano, Teruo
Source:
Biomaterials 2014 v.35 pp. 9802-9810
ISSN:
0142-9612
Subject:
clinical trials; coculture; endothelial cells; extracellular matrix; fibroblasts; fibronectins; medicine; polydimethylsiloxane; temperature; tissue engineering
Abstract:
... Cell-sheet-engineering based regenerative medicine is successfully applied to clinical studies, though cell sheets contain uniformly distributed cells. For the further application to complex tissues/organs, cell sheets with a multi-cellular pattern were highly demanded. Micro-contact printing is a quite useful technique for patterning proteins contained in extracellular matrix (ECM). Because ECM i ...
DOI:
10.1016/j.biomaterials.2014.08.043

18. One-step mixing with humanized anti-mPEG bispecific antibody enhances tumor accumulation and therapeutic efficacy of mPEGylated nanoparticles

Author:
Kao, Chien-Han; Wang, Jaw-Yuan; Chuang, Kuo-Hsiang; Chuang, Chih-Hung; Cheng, Ta-Chun; Hsieh, Yuan-Chin; Tseng, Yun-long; Chen, Bing-Mae; Roffler, Steve R.; Cheng, Tian-Lu
Source:
Biomaterials 2014 v.35 pp. 9930-9940
ISSN:
0142-9612
Subject:
animal models; antibodies; antineoplastic activity; doxorubicin; humans; image analysis; mixing; nanoparticles; neoplasm cells; neoplasms; polyethylene glycol; therapeutics
Abstract:
... Methoxy PEGylated nanoparticles (mPEG-NPs) are increasingly used for cancer imaging and therapy. Here we describe a general and simple approach to confer tumor tropism to any mPEG-NP. We demonstrate this approach with humanized bispecific antibodies (BsAbs) that can bind to both mPEG molecules on mPEG-NPs and to EGFR or HER2 molecules overexpressed on the surface of cancer cells. Simple mixing of ...
DOI:
10.1016/j.biomaterials.2014.08.032

19. Paper-based bioactive scaffolds for stem cell-mediated bone tissue engineering

Author:
Park, Hyun-Ji; Yu, Seung Jung; Yang, Kisuk; Jin, Yoonhee; Cho, Ann-Na; Kim, Jin; Lee, Bora; Yang, Hee Seok; Im, Sung Gap; Cho, Seung-Woo
Source:
Biomaterials 2014 v.35 pp. 9811-9823
ISSN:
0142-9612
Subject:
bone formation; bones; cell culture; coatings; cost effectiveness; endothelial cells; films (materials); humans; paper; polymers; stem cells; tissue engineering; tissue repair; vapors
Abstract:
... Bioactive, functional scaffolds are required to improve the regenerative potential of stem cells for tissue reconstruction and functional recovery of damaged tissues. Here, we report a paper-based bioactive scaffold platform for stem cell culture and transplantation for bone reconstruction. The paper scaffolds are surface-engineered by an initiated chemical vapor deposition process for serial coat ...
DOI:
10.1016/j.biomaterials.2014.09.002

20. PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy

Author:
Cheng, Liang; Gong, Hua; Zhu, Wenwen; Liu, Jingjing; Wang, Xiaoyong; Liu, Gang; Liu, Zhuang
Source:
Biomaterials 2014 v.35 pp. 9844-9852
ISSN:
0142-9612
Subject:
image analysis; magnetism; intravenous injection; hematologic tests; absorbance; coatings; nanomaterials; neoplasms; models; tomography; mice; polyethylene glycol; toxicity; irradiation
Abstract:
... Theranostic agents with both imaging and therapeutic functions have attracted enormous interests in cancer diagnosis and treatment in recent years. In this work, we develop a novel theranostic agent based on Prussian blue nanocubes (PB NCs), a clinically approved agent with strong near-infrared (NIR) absorbance and intrinsic paramagnetic property, for in vivo bimodal imaging-guided photothermal th ...
DOI:
10.1016/j.biomaterials.2014.09.004