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- Ke, Xi-Yu; Lin Ng, Victor Wee; Gao, Shu-Jun; Tong, Yen Wah; Hedrick, James L.; Yang, Yi Yan
- Biomaterials 2014 v.35 no.3 pp. 1096-1108
- antineoplastic activity; breast neoplasms; cell growth; composite polymers; cytotoxicity; doxorubicin; humans; mice; micelles; neoplasm cells; phenotype; polyethylene glycol; stem cells; therapeutics
- ... In this study, thioridazine (THZ), which was reported to kill cancer stem cells, was used in a combination therapy with doxorubicin (DOX) to eradicate both cancer cells and DOX-resistant cancer stem cells to mitigate the reoccurrence of the disease. Both THZ and DOX were loaded into micelles with sizes below 100 nm, narrow size distribution and high drug content. The micelles were self-assembled f ...
- Müller, Karin H.; Motskin, Michael; Philpott, Alistair J.; Routh, Alexander F.; Shanahan, Catherine M.; Duer, Melinda J.; Skepper, Jeremy N.
- Biomaterials 2014 v.35 no.3 pp. 1074-1088
- calcification; cytotoxicity; dispersants; dose response; extracellular space; humans; hydroxyapatite; image analysis; macrophages; medicine; nanoparticles
- ... Agglomeration dramatically affects many aspects of nanoparticle–cell interactions. Here we show that hydroxyapatite nanoparticles formed large agglomerates in biological medium resulting in extensive particle uptake and dose-dependent cytotoxicity in human macrophages. Particle citration and/or the addition of the dispersant Darvan 7 dramatically reduced mean agglomerate sizes, the amount of parti ...