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You searched for: Journal name Biomaterials Remove constraint Journal name: Biomaterials Subject term calcitonin Remove constraint Subject term: calcitonin
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1. RANKL-associated suppression of particle-induced osteolysis in an aged model of Calcitonin and α-CGRP deficiency

Author:
Max D. Kauther; Carl Neuerburg; Florian Wefelnberg; Hagen S. Bachmann; Rüdiger Schlepper; Gero Hilken; Martina Broecker-Preuss; Florian Grabellus; Arndt F. Schilling; Marcus Jäger; Christian Wedemeyer
Source:
Biomaterials 2013 v.34 pp. 2911-2919
ISSN:
0142-9612
Subject:
blood serum; bone metabolism; calcitonin; calcitonin gene-related peptide; mice; models; morphometry; surgery; young animals
Abstract:
... An aging population with higher bone turnover intensifies the need for joint replacement surgery. However, particle-induced osteolysis (PIO) remains a major cause of early implant loosening. Differences in bone remodeling between young and aged Calcitonin (CT)- and α-CGRP (Calcitonin gene-related peptide)-deficient mice (Calca−/−) might modify our previous findings regarding CT/α-CGRP in PIO. This ...
DOI:
10.1016/j.biomaterials.2013.01.034

2. The role of the ERK1/2 pathway as an alternative to the aging-diminished cyclic AMP pathway in calcitonin-mediated chondrogenesis in human nucleus pulposus

Author:
Wei-Hong Chen; Rong Zeng; Wen-Cheng Lo; Szu-Yu Tina Chen; Tung-Yuan Lai; David F. Williams; Win-Ping Deng
Source:
Biomaterials 2012 v.33 no.33 pp. 8256-8264
ISSN:
0142-9612
Subject:
calcitonin; calcitonin receptors; chondrogenesis; cyclic AMP; humans; phenotype; signal transduction; therapeutics
Abstract:
... Human disc degeneration initiated by aging in the central nucleus pulposus (hNP) is an irreversible process and the recovery has become seriously emerging. In this study, the related mechanisms of calcitonin on the regeneration of hNP and the effects of calcitonin on the age-related alterations were examined. The harvested hNP population was designated as YhNP (from young donor, age <50) and OhNP ...
DOI:
10.1016/j.biomaterials.2012.06.088

3. The use of polyion complex micelles to enhance the oral delivery of salmon calcitonin and transport mechanism across the intestinal epithelial barrier

Author:
Na Li; Xin-Ru Li; Yan-Xia Zhou; Wen-Jing Li; Yong Zhao; Shu-Jin Ma; Jin-Wen Li; Ya-Jie Gao; Yan Liu; Xing-Lin Wang; Dong-Dong Yin
Source:
Biomaterials 2012 v.33 no.34 pp. 8881-8892
ISSN:
0142-9612
Subject:
absorption; actin; calcitonin; composite polymers; confocal laser scanning microscopy; cytoskeleton; cytotoxicity; digestive system; drugs; electrical resistance; endocytosis; human cell lines; hypocalcemia; micelles; permeability; physiological transport; rats; salmon; tight junctions; transmission electron microscopy
Abstract:
... The objective of the present study was to demonstrate the effect of polyanionic copolymer mPEG-grafted-alginic acid (mPEG-g-AA)-based polyion complex (PIC) micelles on enhancing the oral absorption of salmon calcitonin (sCT) in vivo and in vitro and identify the transepithelial transport mechanism of PIC micelles across the intestinal barrier. mPEG-g-AA was first successfully synthesized and chara ...
DOI:
10.1016/j.biomaterials.2012.08.047