Jump to Main Content
- Kenzo Morinaga; Hodaka Sasaki; Sil Park; Akishige Hokugo; Hiroko Okawa; Yu Tahara; Christopher S. Colwell; Ichiro Nishimura
- Biomaterials 2019 v.192 pp. 62-74
- active ingredients; alpha-2 adrenergic receptors; animal models; beta-2 adrenergic receptors; biocompatible materials; bone marrow; circadian clocks; collagen; cyclic AMP; femur; gene components; genetics; humans; medical equipment; medicinal properties; mesenchymal stromal cells; mice; neurons; screening; signal transduction; titanium
- ... Titanium (Ti) biomaterials have been applied to a wide range of implantable medical devices. When placed in bone marrow, Ti-biomaterials integrate to the surrounding bone tissue by mechanisms that are not fully understood. We have previously identified an unexpected upregulation of circadian clock molecule neuronal PAS domain 2 (Npas2) in successfully integrated implant with a rough surface. This ...
- PubMed Central:
- Wei-Hong Chen; Rong Zeng; Wen-Cheng Lo; Szu-Yu Tina Chen; Tung-Yuan Lai; David F. Williams; Win-Ping Deng
- Biomaterials 2012 v.33 no.33 pp. 8256-8264
- calcitonin; calcitonin receptors; chondrogenesis; cyclic AMP; humans; phenotype; signal transduction; therapeutics
- ... Human disc degeneration initiated by aging in the central nucleus pulposus (hNP) is an irreversible process and the recovery has become seriously emerging. In this study, the related mechanisms of calcitonin on the regeneration of hNP and the effects of calcitonin on the age-related alterations were examined. The harvested hNP population was designated as YhNP (from young donor, age <50) and OhNP ...