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You searched for: Author "Chen, Szu-Yu" Remove constraint Author: "Chen, Szu-Yu" Journal Biomaterials Remove constraint Journal: Biomaterials
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1. Delayed animal aging through the recovery of stem cell senescence by platelet rich plasma

Author:
Tina Chen, Szu-Yu,   et al.   ; Liu, Hen-Yu; Huang, Chiung-Fang; Lin, Tzu-Chieh; Tsai, Ching-Yu; Liu, Alice; Chen, Wei-Hong; Wei, Hong-Jian; Wang, Ming-Fu; Williams, David F.; Deng, Win-Ping;     Show all 11 Authors
Source:
Biomaterials 2014 v.35 pp. 9767-9776
ISSN:
0142-9612
Subject:
adipogenesis; alternative medicine; body weight; bone formation; bone marrow; cell growth; cell proliferation; cell senescence; fibroblasts; longevity; mice; oxidative stress; phenotype; stem cells; tissue repair
Abstract:
... Aging is related to loss of functional stem cell accompanying loss of tissue and organ regeneration potentials. Previously, we demonstrated that the life span of ovariectomy-senescence accelerated mice (OVX-SAMP8) was significantly prolonged and similar to that of the congenic senescence-resistant strain of mice after platelet rich plasma (PRP)/embryonic fibroblast transplantation. The aim of this ...
DOI:
10.1016/j.biomaterials.2014.08.034

2. Synergistic anabolic actions of hyaluronic acid and platelet-rich plasma on cartilage regeneration in osteoarthritis therapy

Author:
Tina Chen, Szu-Yu,   et al.   ; Chen, Wei-Hong; Lo, Wen-Cheng; Hsu, Wei-Che; Wei, Hong-Jian; Liu, Hen-Yu; Lee, Chian-Her; Shieh, Ying-Hua; Williams, David F.; Deng, Win-Ping;     Show all 10 Authors
Source:
Biomaterials 2014 v.35 no.36 pp. 9599-9607
ISSN:
0142-9612
Subject:
cartilage; chemokines; chondrocytes; genes; homeostasis; hyaluronic acid; immunoblotting; inflammation; models; osteoarthritis; patients; phenotype; receptors; reverse transcriptase polymerase chain reaction; signal transduction; therapeutics; tissue repair; transcription factors
Abstract:
... Osteoarthritis (OA) is a common disease associated with tissue inflammation, physical disability and imbalanced homeostasis in cartilage. For advanced treatments, biological approaches are currently focused on tissue regeneration and anti-inflammation. This study was undertaken to evaluate the therapeutic efficacies of hyaluronic acid (HA) and platelet-rich plasma (PRP) (HA+PRP) on OA. Articular c ...
DOI:
10.1016/j.biomaterials.2014.07.058

3. The role of the ERK1/2 pathway as an alternative to the aging-diminished cyclic AMP pathway in calcitonin-mediated chondrogenesis in human nucleus pulposus

Author:
Tina Chen, Szu-Yu,   et al.   ; Chen, Wei-Hong; Zeng, Rong; Lo, Wen-Cheng; Lai, Tung-Yuan; Williams, David F.; Deng, Win-Ping;     Show all 7 Authors
Source:
Biomaterials 2012 v.33 no.33 pp. 8256-8264
ISSN:
0142-9612
Subject:
calcitonin; calcitonin receptors; chondrogenesis; cyclic AMP; humans; phenotype; signal transduction; therapeutics
Abstract:
... Human disc degeneration initiated by aging in the central nucleus pulposus (hNP) is an irreversible process and the recovery has become seriously emerging. In this study, the related mechanisms of calcitonin on the regeneration of hNP and the effects of calcitonin on the age-related alterations were examined. The harvested hNP population was designated as YhNP (from young donor, age <50) and OhNP ...
DOI:
10.1016/j.biomaterials.2012.06.088