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- Li, Shuyi, et al. Show all 10 Authors
- Biomaterials 2017 v.144 pp. 119-129
- cisplatin; drug therapy; encapsulation; ethacrynic acid; glutathione transferase; micelles; nanoparticles; neoplasm cells; neoplasms; platinum; resistance mechanisms; toxicity
- ... Platinum-based DNA-adducting agents are used extensively in the clinic for cancer chemotherapy. However, the anti-tumor efficacy of these drugs is severely limited by cisplatin resistance, and this can lead to the failure of chemotherapy. One of cisplatin resistance mechanisms is associated with overexpression of glutathione S-transferases (GSTs), which would accelerate the deactivation of cisplat ...