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- Routh, Alexander F., et al. Show all 7 Authors
- Biomaterials 2014 v.35 no.3 pp. 1074-1088
- calcification; cytotoxicity; dispersants; dose response; extracellular space; humans; hydroxyapatite; image analysis; macrophages; medicine; nanoparticles
- ... Agglomeration dramatically affects many aspects of nanoparticle–cell interactions. Here we show that hydroxyapatite nanoparticles formed large agglomerates in biological medium resulting in extensive particle uptake and dose-dependent cytotoxicity in human macrophages. Particle citration and/or the addition of the dispersant Darvan 7 dramatically reduced mean agglomerate sizes, the amount of parti ...