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- Silver, Jonathan; Li, Zhenyu; Neuman, Keir
- Biosensors & bioelectronics 2015 v.63 pp. 117-123
- antigen-antibody complex, etc ; DNA; biosensors; biotin; microscopy; streptavidin; Show all 6 Subjects
- ... We describe a proof-of-principle, immune sandwich assay in which immune complexes link micron-size beads via DNA tethers to a sensor surface. The number of tethered beads, counted using low-magnification microscopy, provides a measure of the concentration of analyte. The prototype assay was sensitive to pM concentration of analyte. In theory, the assay could be sensitive to sub-fM analyte because ...
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