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1. A blow to the fly — Lucilia cuprina draft genome and transcriptome to support advances in biology and biotechnology

Author:
Anstead, Clare A.; Batterham, Philip; Korhonen, Pasi K.; Young, Neil D.; Hall, Ross S.; Bowles, Vernon M.; Richards, Stephen; Scott, Maxwell J.; Gasser, Robin B.
Source:
Biotechnology advances 2016 v.34 no.5 pp. 605-620
ISSN:
0734-9750
Subject:
Lucilia cuprina; animals; biochemistry; biotechnology; excretion; flystrike; genome; hosts; insect genetics; insect larvae; insecticide resistance; insects; molecular biology; parasitism; skin (animal); transcriptome
Abstract:
... The blow fly, Lucilia cuprina (Wiedemann, 1830) is a parasitic insect of major global economic importance. Maggots of this fly parasitize the skin of animal hosts, feed on excretions and tissues, and cause severe disease (flystrike or myiasis). Although there has been considerable research on L. cuprina over the years, little is understood about the molecular biology, biochemistry and genetics of ...
DOI:
10.1016/j.biotechadv.2016.02.009

2. Advances in Chromobacterium violaceum and properties of violacein-Its main secondary metabolite: A review

Author:
Durán, Nelson; Justo, Giselle Z.; Durán, Marcela; Brocchi, Marcelo; Cordi, Livia; Tasic, Ljubica; Castro, Guillermo R.; Nakazato, Gerson
Source:
Biotechnology advances 2016 v.34 no.5 pp. 1030-1045
ISSN:
0734-9750
Subject:
Alteromonas; Chromobacterium violaceum; Duganella; Escherichia; Janthinobacterium; Pseudoalteromonas; antibacterial properties; antineoplastic activity; antiparasitic agents; bacteria; biosynthesis; cosmetics; fabrics; industrial applications; monitoring; quorum sensing; secondary metabolites
Abstract:
... Chromobacterium violaceum is important in the production of violacein, like other bacteria, such as Alteromonas, Janthinobacterium, Pseudoalteromonas, Duganella, Collimonas and Escherichia. Violacein is a versatile pigment, where it exhibits several biological activities, and every year, it shows increasing commercially interesting uses, especially for industrial applications in cosmetics, medicin ...
DOI:
10.1016/j.biotechadv.2016.06.003

3. Advances in pulmonary therapy and drug development: Lung tissue engineering to lung-on-a-chip

Author:
Doryab, Ali; Amoabediny, Ghassem; Salehi-Najafabadi, Amir
Source:
Biotechnology advances 2016 v.34 no.5 pp. 588-596
ISSN:
0734-9750
Subject:
animal use replacement; drug therapy; organ-on-a-chip; drugs; respiratory tract diseases; immune system; patients; lungs; death; tissue engineering; screening; toxicity
Abstract:
... Lung disease is one of the major causes of death, and the rate of pulmonary diseases has been increasing for decades. Although lung transplantation is the only treatment for majority of patients, this method has been limited due to lack of donors. Therefore, recently, attentions have increased to some new strategies with the aid of tissue engineering and microfluidics techniques not only for the f ...
DOI:
10.1016/j.biotechadv.2016.02.006

4. Antimicrobial peptides as novel anti-tuberculosis therapeutics

Author:
Silva, João P.; Appelberg, Rui; Gama, Francisco Miguel
Source:
Biotechnology advances 2016 v.34 no.5 pp. 924-940
ISSN:
0734-9750
Subject:
Mycobacterium tuberculosis; antibiotics; antimicrobial peptides; drugs; humans; innate immunity; markets; mechanism of action; medicinal properties; multiple drug resistance; pathogens; therapeutics; tuberculosis
Abstract:
... Tuberculosis (TB), a disease caused by the human pathogen Mycobacterium tuberculosis, has recently joined HIV/AIDS as the world's deadliest infectious disease, affecting around 9.6 million people worldwide in 2014. Of those, about 1.2 million died from the disease.Resistance acquisition to existing antibiotics, with the subsequent emergence of Multi-Drug Resistant mycobacteria strains, together wi ...
DOI:
10.1016/j.biotechadv.2016.05.007

5. Beyond the outer limits of nature by directed evolution

Author:
Molina-Espeja, Patricia; Viña-Gonzalez, Javier; Gomez-Fernandez, Bernardo J.; Martin-Diaz, Javier; Garcia-Ruiz, Eva; Alcalde, Miguel
Source:
Biotechnology advances 2016 v.34 no.5 pp. 754-767
ISSN:
0734-9750
Subject:
DNA; amino acids; bioremediation; biotechnology; case studies; directed evolution; gene therapy; medicine; proteins
Abstract:
... For more than thirty years, biotechnology has borne witness to the power of directed evolution in designing molecules of industrial relevance. While scientists all over the world discuss the future of molecular evolution, dozens of laboratory-designed products are being released with improved characteristics in terms of turnover rates, substrate scope, catalytic promiscuity or stability. In this r ...
DOI:
10.1016/j.biotechadv.2016.03.008

6. Bio-recovery of non-essential heavy metals by intra- and extracellular mechanisms in free-living microorganisms

Author:
García-García, Jorge D.; Sánchez-Thomas, Rosina; Moreno-Sánchez, Rafael
Source:
Biotechnology advances 2016 v.34 no.5 pp. 859-873
ISSN:
0734-9750
Subject:
bacteria; biosynthesis; chloroplasts; cyanides; engineering; genetically engineered microorganisms; heavy metals; leaching; malates; metal ions; metallothionein; microalgae; mitochondria; models; phosphates; protists; recycling; secretion; soil; transcription (genetics); vacuoles; wastewater
Abstract:
... Free-living microorganisms may become suitable models for recovery of non-essential and essential heavy metals from wastewater bodies and soils by using and enhancing their accumulating and/or leaching abilities. This review analyzes the variety of different mechanisms developed mainly in bacteria, protists and microalgae to accumulate heavy metals, being the most relevant those involving phytoche ...
DOI:
10.1016/j.biotechadv.2016.05.003

7. Curcumin, mitochondrial biogenesis, and mitophagy: Exploring recent data and indicating future needs

Author:
de Oliveira, Marcos Roberto; Jardim, Fernanda Rafaela; Setzer, William N.; Nabavi, Seyed Mohammad; Nabavi, Seyed Fazel
Source:
Biotechnology advances 2016 v.34 no.5 pp. 813-826
ISSN:
0734-9750
Subject:
apoptosis; autophagy; bioavailability; biogenesis; biosynthesis; calcium; curcumin; energy; mitochondria; neurodegenerative diseases; polyphenols; stress response; turmeric
Abstract:
... Mitochondria are dynamic double-membrane bound organelles which have key roles in a variety of cellular functions such as energy producing, regulation of calcium flux, cellular stress responses including autophagy and apoptosis. A growing body of evidence indicates that mitochondrial dysfunction is the main culprit in a myriad of diseases such as neurodegenerative disease. This fact opens a new th ...
DOI:
10.1016/j.biotechadv.2016.04.004

8. Current advances in molecular, biochemical, and computational modeling analysis of microalgal triacylglycerol biosynthesis

Author:
Lenka, Sangram K.; Carbonaro, Nicole; Park, Rudolph; Miller, Stephen M.; Thorpe, Ian; Li, Yantao
Source:
Biotechnology advances 2016 v.34 no.5 pp. 1046-1063
ISSN:
0734-9750
Subject:
algae culture; biodiesel; biologists; biosynthesis; data collection; endoplasmic reticulum; energy; fatty acids; fuel production; genetic engineering; lipid metabolism; mathematical models; metabolic flux analysis; microalgae; plastids; triacylglycerols
Abstract:
... Triacylglycerols (TAGs) are highly reduced energy storage molecules ideal for biodiesel production. Microalgal TAG biosynthesis has been studied extensively in recent years, both at the molecular level and systems level through experimental studies and computational modeling. However, discussions of the strategies and products of the experimental and modeling approaches are rarely integrated and s ...
DOI:
10.1016/j.biotechadv.2016.06.004

9. Functionally graded materials for orthopedic applications – an update on design and manufacturing

Author:
Sola, Antonella; Bellucci, Devis; Cannillo, Valeria
Source:
Biotechnology advances 2016 v.34 no.5 pp. 504-531
ISSN:
0734-9750
Subject:
biomechanics; bones; coatings; geometry; humans; manufacturing; microstructure; orthopedics; porosity; prostheses; shear stress
Abstract:
... Functionally graded materials (FGMs) are innovative materials whose composition and/or microstructure gradually vary in space according to a designed law. As a result, also the properties gradually vary in space, so as to meet specific non-homogeneous service requirements without any abrupt interface at the macroscale. FGMs are emerging materials for orthopedic prostheses, since the functional gra ...
DOI:
10.1016/j.biotechadv.2015.12.013

10. Genetic improvement of olive (Olea europaea L.) by conventional and in vitro biotechnology methods

Author:
Rugini, E.; Cristofori, V.; Silvestri, C.
Source:
Biotechnology advances 2016 v.34 no.5 pp. 687-696
ISSN:
0734-9750
Subject:
Olea europaea; apical dominance; biotechnology; biotic stress; cultivars; fruits; gene pool; gene therapy; genetic improvement; genetic relationships; genotype; germplasm; groves; growth habit; heirloom varieties; hybridization; mechanization; new variety; oils; olives; orchards
Abstract:
... In olive (Olea europaea L.) traditional methods of genetic improvement have up to now produced limited results. Intensification of olive growing requires appropriate new cultivars for fully mechanized groves, but among the large number of the traditional varieties very few are suitable. High-density and super high-density hedge row orchards require genotypes with reduced size, reduced apical domin ...
DOI:
10.1016/j.biotechadv.2016.03.004

11. Genetic modification of plant cell walls to enhance biomass yield and biofuel production in bioenergy crops

Author:
Wang, Yanting; Fan, Chunfen; Hu, Huizhen; Li, Ying; Sun, Dan; Wang, Youmei; Peng, Liangcai
Source:
Biotechnology advances 2016 v.34 no.5 pp. 997-1017
ISSN:
0734-9750
Subject:
biofuels; biomass production; cell walls; cellulose; crystal structure; energy crops; enzymatic hydrolysis; fuel production; genes; genetic engineering; grasses; hemicellulose; lignin; lignocellulose; models; mutants; pectins; plant breeding; proteins; saccharification; transgenic plants; trees; uronic acids
Abstract:
... Plant cell walls represent an enormous biomass resource for the generation of biofuels and chemicals. As lignocellulose property principally determines biomass recalcitrance, the genetic modification of plant cell walls has been posed as a powerful solution. Here, we review recent progress in understanding the effects of distinct cell wall polymers (cellulose, hemicelluloses, lignin, pectin, wall ...
DOI:
10.1016/j.biotechadv.2016.06.001

12. Hypoxic tumor microenvironment: Opportunities to develop targeted therapies

Author:
Patel, Akhil; Sant, Shilpa
Source:
Biotechnology advances 2016 v.34 no.5 pp. 803-812
ISSN:
0734-9750
Subject:
byproducts; drug delivery systems; drugs; hypoxia; neoplasms; oxygen; physicochemical properties; signal transduction
Abstract:
... In recent years, there has been great progress in the understanding of tumor biology and its surrounding microenvironment. Solid tumors create regions with low oxygen levels, generally termed as hypoxic regions. These hypoxic areas offer a tremendous opportunity to develop targeted therapies. Hypoxia is not a random by-product of the cellular milieu due to uncontrolled tumor growth; rather it is a ...
DOI:
10.1016/j.biotechadv.2016.04.005
PubMed:
27143654
PubMed Central:
PMC4947437

13. Indocyanine green delivery systems for tumour detection and treatments

Author:
Porcu, Elena P.; Salis, Andrea; Gavini, Elisabetta; Rassu, Giovanna; Maestri, Marcello; Giunchedi, Paolo
Source:
Biotechnology advances 2016 v.34 no.5 pp. 768-789
ISSN:
0734-9750
Subject:
chemical composition; drug delivery systems; fever; fluorescence; humans; hydrocolloids; image analysis; irradiation; lymph nodes; metastasis; neoplasms; reactive oxygen species; surgery
Abstract:
... Indocyanine green (ICG) is a cyanine compound that displays fluorescent properties in the near infrared region. This dye is employed for numerous indications but nowadays its major application field regards tumour diagnosis and treatments. Optical imaging by near infrared fluorescence provides news opportunities for oncologic surgery. The imaging of ICG can be useful for intraoperative identificat ...
DOI:
10.1016/j.biotechadv.2016.04.001

14. Innovation in biological production and upgrading of methane and hydrogen for use as gaseous transport biofuel

Author:
Xia, Ao; Cheng, Jun; Murphy, Jerry D.
Source:
Biotechnology advances 2016 v.34 no.5 pp. 451-472
ISSN:
0734-9750
Subject:
biogas; biological production; biomass; carbon dioxide; energy; fermentation; greenhouse gas emissions; hydrogen; methane; microalgae; pollutants
Abstract:
... Biofuels derived from biomass will play a major role in future renewable energy supplies in transport. Gaseous biofuels have superior energy balances, offer greater greenhouse gas emission reductions and produce lower pollutant emissions than liquid biofuels. Biogas derived through fermentation of wet organic substrates will play a major role in future transport systems. Biogas (which is composed ...
DOI:
10.1016/j.biotechadv.2015.12.009

15. Insights into microbial diversity in wastewater treatment systems: How far have we come?

Author:
Ferrera, Isabel; Sánchez, Olga
Source:
Biotechnology advances 2016 v.34 no.5 pp. 790-802
ISSN:
0734-9750
Subject:
Archaea; bacteria; community structure; ecophysiology; environmental factors; gene expression regulation; genes; high-throughput nucleotide sequencing; microbial activity; microbial communities; nitrogen; phosphorus; sludge; structure-activity relationships; wastewater; wastewater treatment
Abstract:
... Biological wastewater treatment processes are based on the exploitation of the concerted activity of microorganisms. Knowledge on the microbial community structure and the links to the changing environmental conditions is therefore crucial for the development and optimization of biological systems by engineers. The advent of molecular techniques occurred in the last decades quickly showed the inad ...
DOI:
10.1016/j.biotechadv.2016.04.003

16. Making sense of genomes of parasitic worms: Tackling bioinformatic challenges

Author:
Korhonen, Pasi K.; Young, Neil D.; Gasser, Robin B.
Source:
Biotechnology advances 2016 v.34 no.5 pp. 663-686
ISSN:
0734-9750
Subject:
algorithms; animals; biogeography; bioinformatics; data collection; drugs; genes; helminths; hosts; people; phylogeny; prediction; transcription (genetics); transcriptome
Abstract:
... Billions of people and animals are infected with parasitic worms (helminths). Many of these worms cause diseases that have a major socioeconomic impact worldwide, and are challenging to control because existing treatment methods are often inadequate. There is, therefore, a need to work toward developing new intervention methods, built on a sound understanding of parasitic worms at molecular level, ...
DOI:
10.1016/j.biotechadv.2016.03.001

17. Microbial production of natural and non-natural flavonoids: Pathway engineering, directed evolution and systems/synthetic biology

Author:
Pandey, Ramesh Prasad; Parajuli, Prakash; Koffas, Mattheos A.G.; Sohng, Jae Kyung
Source:
Biotechnology advances 2016 v.34 no.5 pp. 634-662
ISSN:
0734-9750
Subject:
biochemical pathways; directed evolution; enzymes; flavonoids; glycosylation; metabolic engineering; microorganisms; synthetic biology
Abstract:
... In this review, we address recent advances made in pathway engineering, directed evolution, and systems/synthetic biology approaches employed in the production and modification of flavonoids from microbial cells. The review is divided into two major parts. In the first, various metabolic engineering and system/synthetic biology approaches used for production of flavonoids and derivatives are discu ...
DOI:
10.1016/j.biotechadv.2016.02.012

18. Microbial production of propanol

Author:
Walther, Thomas; François, Jean Marie
Source:
Biotechnology advances 2016 v.34 no.5 pp. 984-996
ISSN:
0734-9750
Subject:
1-propanol; biochemical pathways; biofuels; breeding; cost effectiveness; feedstocks; fermentation; isopropyl alcohol; metabolic engineering; microorganisms; propylene; stoichiometry; synthesis; toxicity; value added
Abstract:
... Both, n-propanol and isopropanol are industrially attractive value-added molecules that can be produced by microbes from renewable resources. The development of cost-effective fermentation processes may allow using these alcohols as a biofuel component, or as a precursor for the chemical synthesis of propylene. This review reports and discusses the recent progress which has been made in the bioche ...
DOI:
10.1016/j.biotechadv.2016.05.011

19. Nanotechnology-based strategies for combating toxicity and resistance in melanoma therapy

Author:
Brys, Adam K.; Gowda, Raghavendra; Loriaux, Daniel B.; Robertson, Gavin P.; Mosca, Paul J.
Source:
Biotechnology advances 2016 v.34 no.5 pp. 565-577
ISSN:
0734-9750
Subject:
drug resistance; drug toxicity; drugs; melanoma; nanoparticles; resistance mechanisms; therapeutics
Abstract:
... Drug toxicity and resistance remain formidable challenges in cancer treatment and represent an area of increasing attention in the case of melanoma. Nanotechnology represents a paradigm-shifting field with the potential to mitigate drug resistance while improving drug delivery and minimizing toxicity. Recent clinical and pre-clinical studies have demonstrated how a diverse array of nanoparticles m ...
DOI:
10.1016/j.biotechadv.2016.01.004

20. New marine natural products from sponges (Porifera) of the order Dictyoceratida (2001 to 2012); a promising source for drug discovery, exploration and future prospects

Author:
Mehbub, Mohammad F.; Perkins, Michael V.; Zhang, Wei; Franco, Christopher M.M.
Source:
Biotechnology advances 2016 v.34 no.5 pp. 473-491
ISSN:
0734-9750
Subject:
Dictyoceratida; bioactive properties; chemical structure; geographical distribution; metabolites; new drugs
Abstract:
... The discovery of new drugs can no longer rely primarily on terrestrial resources, as they have been heavily exploited for over a century. During the last few decades marine sources, particularly sponges, have proven to be a most promising source of new natural products for drug discovery. This review considers the order Dictyoceratida in the Phylum Porifera from which the largest number of new mar ...
DOI:
10.1016/j.biotechadv.2015.12.008