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- Yang, Guang, et al. Show all 8 Authors
- Biotechnology and bioprocess engineering 2012 v.17 no.6 pp. 1182-1189
- cell viability; coatings; cytotoxicity; genes; low density lipoprotein; protein synthesis; transfection; vascular endothelial growth factors
- ... The major limitations to non-viral gene delivery are relatively low efficiency and cytotoxicity, which need to be addressed in the design of new vectors. In this study, negatively charged low density lipoproteins (LDL) were coated onto positively charged pVEGF/PEI complexes to form pVEGF/PEI/LDL terplexes by a two-step procedure. The biocompatible LDL was introduced to reduce the cytotoxicity of t ...