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- Costello, Alan; Lao, Nga T.; Barron, Niall; Clynes, Martin
- Biotechnology letters 2019 v.41 no.2 pp. 231-239
- 5' untranslated regions; adenosine; erythropoietin; humans; models; mutants; therapeutics; transgenes; translation (genetics)
- ... The impact of local structure on mRNA translation is not well-defined pertaining to the 5′ UTR. Reports suggest structural remodelling of the 5′ UTR can significantly influence mRNA translation both in cis and trans however a new layer of complexity has been applied to this model with the now known reversible post-transcriptional chemical modification of RNA. N⁶-methyladenosine (m⁶A) is the most a ...