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- Duvall, Laura B.; Ramos-Espiritu, Lavoisier; Barsoum, Kyrollos E.; Glickman, J. Fraser; Vosshall, Leslie B.
- Cell 2019 v.176 no.4 pp. 687-701.e5
- Aedes aegypti; agonists; blood; blood meal; disease control; disease transmission; drugs; eggs; females; hematophagy; host seeking; humans; infectious diseases; mutants; neuropeptide Y; peptide receptors
- ... Female Aedes aegypti mosquitoes bite humans to obtain blood to develop their eggs. Remarkably, their strong attraction to humans is suppressed for days after the blood meal by an unknown mechanism. We investigated a role for neuropeptide Y (NPY)-related signaling in long-term behavioral suppression and discovered that drugs targeting human NPY receptors modulate mosquito host-seeking. In a screen ...
- Gesto, João S.M.; Moreira, Luciano A.
- Cell 2019 v.176 no.4 pp. 679-681
- Aedes aegypti; agonists; disease control; host seeking; hosts; neuropeptide Y; screening; vector-borne diseases
- ... New possibilities for vector-borne disease control are revealed by Duvall et al. (2019), who link host-seeking behavioral modulation in Aedes aegypti to neuropeptide Y (NPY)-like receptor 7. Small-molecule screening yields agonist compounds able to activate NPYLR7 and suppress attraction to hosts. ...