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- Yoon, Jung-Hoon; McArthur, Mark J.; Park, Jeseong; Basu, Debashree; Wakamiya, Maki; Prakash, Louise; Prakash, Satya
- Cell 2019 v.176 no.6 pp. 1295-1309.e15
- DNA; DNA-directed DNA polymerase; carcinogenesis; genome; mice; point mutation; skin neoplasms
- ... Cancers from sun-exposed skin accumulate “driver” mutations, causally implicated in oncogenesis. Because errors incorporated during translesion synthesis (TLS) opposite UV lesions would generate these mutations, TLS mechanisms are presumed to underlie cancer development. To address the role of TLS in skin cancer formation, we determined which DNA polymerase is responsible for generating UV mutatio ...