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- Kalappurakkal, Joseph Mathew; Anilkumar, Anupama Ambika; Patra, Chandrima; van Zanten, Thomas S.; Sheetz, Michael P.; Mayor, Satyajit
- Cell 2019 v.177 no.7 pp. 1738-1756.e23
- CD29 antigen; ligands; lipids; mutants; myosin; nanoparticles; non-specific protein-tyrosine kinase; plasma membrane; signal transduction
- ... Glycosylphosphatidylinositol-anchored proteins (GPI-APs) are a major class of lipid-anchored plasma membrane proteins. GPI-APs form nanoclusters generated by cortical acto-myosin activity. While our understanding of the physical principles governing this process is emerging, the molecular machinery and functional relevance of GPI-AP nanoclustering are unknown. Here, we first show that a membrane r ...