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- Jordan, Stefan; Tung, Navpreet; Casanova-Acebes, Maria; Chang, Christie; Cantoni, Claudia; Zhang, Dachuan; Wirtz, Theresa H.; Naik, Shruti; Rose, Samuel A.; Brocker, Chad N.; Gainullina, Anastasiia; Hornburg, Daniel; Horng, Sam; Maier, Barbara B.; Cravedi, Paolo; LeRoith, Derek; Gonzalez, Frank J.; Meissner, Felix; Ochando, Jordi; Rahman, Adeeb; Chipuk, Jerry E.; Artyomov, Maxim N.; Frenette, Paul S.; Piccio, Laura; Berres, Marie-Luise; Gallagher, Emily J.; Merad, Miriam
- Cell 2019 v.178 no.5 pp. 1102-1114.e17
- autoimmune diseases; bone marrow; chemokine CCL2; energy intake; fasting; food intake; glucose; hepatocytes; inflammation; liver; low calorie diet; monocytes; peroxisome proliferator-activated receptor alpha; protein content; protein kinases; tissue repair
- ... Caloric restriction is known to improve inflammatory and autoimmune diseases. However, the mechanisms by which reduced caloric intake modulates inflammation are poorly understood. Here we show that short-term fasting reduced monocyte metabolic and inflammatory activity and drastically reduced the number of circulating monocytes. Regulation of peripheral monocyte numbers was dependent on dietary gl ...