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- Wang, Fengbin; Gu, Yangqi; O’Brien, J. Patrick; Yi, Sophia M.; Yalcin, Sibel Ebru; Srikanth, Vishok; Shen, Cong; Vu, Dennis; Ing, Nicole L.; Hochbaum, Allon I.; Egelman, Edward H.; Malvankar, Nikhil S.
- Cell 2019 v.177 no.2 pp. 361-369.e10
- histidine, etc ; Geobacter sulfurreducens; cryo-electron microscopy; electrons; energy; fimbriae; heme; nanowires; polymerization; soil bacteria; Show all 10 Subjects
- ... Long-range (>10 μm) transport of electrons along networks of Geobacter sulfurreducens protein filaments, known as microbial nanowires, has been invoked to explain a wide range of globally important redox phenomena. These nanowires were previously thought to be type IV pili composed of PilA protein. Here, we report a 3.7 Å resolution cryoelectron microscopy structure, which surprisingly reveals tha ...
- Chen, Haiwei; Nwe, Phu-Khat; Yang, Yi; Rosen, Connor E.; Bielecka, Agata A.; Kuchroo, Manik; Cline, Gary W.; Kruse, Andrew C.; Ring, Aaron M.; Crawford, Jason M.; Palm, Noah W.
- Cell 2019 v.177 no.5 pp. 1217-1231.e18
- histidine, etc ; G-protein coupled receptors; G-proteins; agonists; amine oxidase (flavin-containing); bacteria; blood-brain barrier; enzyme inhibitors; essential amino acids; histamine; humans; intestinal microorganisms; metabolites; metabolome; phenethylamine; poisoning; Show all 16 Subjects
- ... The intestinal microbiota produces tens of thousands of metabolites. Here, we used host sensing of small molecules by G-protein coupled receptors (GPCRs) as a lens to illuminate bioactive microbial metabolites that impact host physiology. We screened 144 human gut bacteria against the non-olfactory GPCRome and identified dozens of bacteria that activated both well-characterized and orphan GPCRs, i ...