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- Ma, Weirui; Mayr, Christine
- Cell 2018 v.175 no.6 pp. 1492-1506.e19
- RNA-binding proteins; amino acid sequences; endoplasmic reticulum; functional diversity; genes; granules; humans; membrane proteins; messenger RNA; protein-protein interactions
- ... Approximately half of human genes generate mRNAs with alternative 3′ untranslated regions (3′UTRs). Through 3′UTR-mediated protein-protein interactions, alternative 3′UTRs enable multi-functionality of proteins with identical amino acid sequence. While studying how information on protein features is transferred from 3′UTRs to proteins, we discovered that the broadly expressed RNA-binding protein T ...
- Chitwood, Patrick J.; Juszkiewicz, Szymon; Guna, Alina; Shao, Sichen; Hegde, Ramanujan S.
- Cell 2018 v.175 no.6 pp. 1507-1519.e16
- beta-1 adrenergic receptors; biogenesis; endoplasmic reticulum; mammals; signal peptide; topology
- ... Mammals encode ∼5,000 integral membrane proteins that need to be inserted in a defined topology at the endoplasmic reticulum (ER) membrane by mechanisms that are incompletely understood. Here, we found that efficient biogenesis of β1-adrenergic receptor (β1AR) and other G protein-coupled receptors (GPCRs) requires the conserved ER membrane protein complex (EMC). Reconstitution studies of β1AR biog ...