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- Li, Yongguo; Schnabl, Katharina; Gabler, Sarah-Madeleine; Willershäuser, Monja; Reber, Josefine; Karlas, Angelos; Laurila, Sanna; Lahesmaa, Minna; u Din, Mueez; Bast-Habersbrunner, Andrea; Virtanen, Kirsi A.; Fromme, Tobias; Bolze, Florian; O’Farrell, Libbey S.; Alsina-Fernandez, Jorge; Coskun, Tamer; Ntziachristos, Vasilis; Nuutila, Pirjo; Klingenspor, Martin
- Cell 2018 v.175 no.6 pp. 1561-1574.e12
- animal disease models; brain; brown adipocytes; brown adipose tissue; clinical trials; digestive system; energy expenditure; glucose; heat production; humans; ingestion; lipolysis; mice; obesity; satiety; secretin; secretin receptors
- ... The molecular mediator and functional significance of meal-associated brown fat (BAT) thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non-sympathetic BAT activator mediating prandial thermogenesis, which consequentially induces satiation, thereby establishing a gut-secretin-BAT-brain axis in mammals with a physiological role of prandial thermogenesis in the control ...
- Mynatt, Randall L.; Ravussin, Eric
- Cell 2018 v.175 no.6 pp. 1459-1460
- brown adipose tissue; digestive system; food intake; heat production; receptors; satiety; secretin
- ... Most theories of meal-induced thermogenesis involve a gut-brain-brown adipose tissue axis driving sympathetic nervous system-mediated thermogenesis. Li et al. demonstrate that secretin released by the gut after a meal binds to abundant receptors in brown adipose tissue to stimulate thermogenesis, inhibiting food intake and thereby suggesting a novel role for secretin regulating satiety. ...