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- Shin, Yongdae; Chang, Yi-Che; Lee, Daniel S.W.; Berry, Joel; Sanders, David W.; Ronceray, Pierre; Wingreen, Ned S.; Haataja, Mikko; Brangwynne, Clifford P.
- Cell 2018 v.175 no.6 pp. 1481-1491.e13
- cell nucleolus; chromatin; condensates; energy; filters; genome; genomics; liquids; loci; optogenetics; phase transition; separation; transcription (genetics)
- ... Phase transitions involving biomolecular liquids are a fundamental mechanism underlying intracellular organization. In the cell nucleus, liquid-liquid phase separation of intrinsically disordered proteins (IDPs) is implicated in assembly of the nucleolus, as well as transcriptional clusters, and other nuclear bodies. However, it remains unclear whether and how physical forces associated with nucle ...
- Welsh, Timothy J.; Shen, Yi; Levin, Aviad; Knowles, Tuomas P.J.
- Cell 2018 v.175 no.6 pp. 1457-1459
- biophysics; chromatin; condensates; droplets; forces; optogenetics; separation
- ... The use of optogenetic approaches has revealed new roles for intracellular protein condensates described in two papers in this issue of Cell (Bracha et. al., 2018; Shin et al., 2018). These results show that growing condensates are able to exert mechanical forces resulting in chromatin rearrangement, establishing a new role for liquid-liquid phase separation in the mechanobiology of the cell. ...