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- Sen, Payel; Shah, Parisha P.; Nativio, Raffaella; Berger, Shelley L.
- Cell 2016 v.166 pp. 822-839
- longevity, etc ; chromatin; epigenetics; humans; invertebrates; models; mortality; risk; therapeutics; tissues; Show all 10 Subjects
- ... Aging is an inevitable outcome of life, characterized by progressive decline in tissue and organ function and increased risk of mortality. Accumulating evidence links aging to genetic and epigenetic alterations. Given the reversible nature of epigenetic mechanisms, these pathways provide promising avenues for therapeutics against age-related decline and disease. In this review, we provide a compre ...
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