Jump to Main Content
- Smider, Vaughn V., et al. Show all 13 Authors
- Cell 2013 v.153 pp. 1379-1393
- antibodies; antibody diversity; antigens; cows; crystal structure; cysteine; high-throughput nucleotide sequencing; immune system; mutation
- ... Some species mount a robust antibody response despite having limited genome-encoded combinatorial diversity potential. Cows are unusual in having exceptionally long CDR H3 loops and few V regions, but the mechanism for creating diversity is not understood. Deep sequencing reveals that ultralong CDR H3s contain a remarkable complexity of cysteines, suggesting that disulfide-bonded minidomains may a ...
- PubMed Central: