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1. A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response

Author:
Hoshii, Takayuki,   et al.   ; Cifani, Paolo; Feng, Zhaohui; Huang, Chun-Hao; Koche, Richard; Chen, Chun-Wei; Delaney, Christopher D.; Lowe, Scott W.; Kentsis, Alex; Armstrong, Scott A.;     Show all 10 Authors
Source:
Cell 2018 v.172 pp. 1007-1021.e17
ISSN:
0092-8674
Subject:
DNA damage; apoptosis; cell viability; chromatin; cyclins; gene expression; genes; histones; interphase; lysine; methylation; methyltransferases; mutagenesis; myeloid leukemia; screening
Abstract:
... MLL/SET methyltransferases catalyze methylation of histone 3 lysine 4 and play critical roles in development and cancer. We assessed MLL/SET proteins and found that SETD1A is required for survival of acute myeloid leukemia (AML) cells. Mutagenesis studies and CRISPR-Cas9 domain screening show the enzymatic SET domain is not necessary for AML cell survival but that a newly identified region termed ...
DOI:
10.1016/j.cell.2018.01.032