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- Song, Xiangyu, et al. Show all 4 Authors
- Cell 2012 v.151 no.5 pp. 1113-1125
- Drosophila; brain; calcium; chemical structure; feeding behavior; fructose; hemolymph; image analysis; mechanism of action; neurons; taste receptors
- ... Internal nutrient sensors play important roles in feeding behavior, yet their molecular structure and mechanism of action are poorly understood. Using Ca²⁺ imaging and behavioral assays, we show that the gustatory receptor 43a (Gr43a) functions as a narrowly tuned fructose receptor in taste neurons. Remarkably, Gr43a also functions as a fructose receptor in the brain. Interestingly, hemolymph fruc ...
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