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- Yang, Fuquan, et al. Show all 9 Authors
- Cell 2019 v.176 no.3 pp. 625-635.e14
- Human immunodeficiency virus 1; genes; messenger RNA; ribosomes; translation (genetics); virus replication; viruses
- ... Programmed -1 ribosomal frameshifting (-1PRF) is a widely used translation recoding mechanism. HIV-1 expresses Gag-Pol protein from the Gag-coding mRNA through -1PRF, and the ratio of Gag to Gag-Pol is strictly maintained for efficient viral replication. Here, we report that the interferon-stimulated gene product C19orf66 (herein named Shiftless) is a host factor that inhibits the -1PRF of HIV-1. ...