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- Muhammad, Suleiman Alhaji; Nordin, Norshariza; Mehat, Muhammad Zulfadli; Fakurazi, Sharida
- Cell and tissue research 2019 v.375 no.2 pp. 329-344
- animal models; animals; cartilage; cell transplantation; databases; meta-analysis; osteoarthritis; risk; stem cells; systematic review
- ... Articular cartilage defect remains the most challenging joint disease due to limited intrinsic healing capacity of the cartilage that most often progresses to osteoarthritis. In recent years, stem cell therapy has evolved as therapeutic strategies for articular cartilage regeneration. However, a number of studies have shown that therapeutic efficacy of stem cell transplantation is attributed to mu ...
- Derricott, Hayley; Luu, Lisa; Fong, Wai Yee; Hartley, Catherine S.; Johnston, Luke J.; Armstrong, Stuart D.; Randle, Nadine; Duckworth, Carrie A.; Campbell, Barry J.; Wastling, Jonathan M.; Coombes, Janine L.
- Cell and tissue research 2019 v.375 no.2 pp. 409-424
- Salmonella Typhimurium; Toxoplasma gondii; animal models; cattle; confocal microscopy; cryopreservation; epithelial cells; host-pathogen relationships; human population; humans; intestinal crypts; jejunum; morbidity; mortality; pathogens; renewable resources; rodents; slaughterhouses; staining; stem cells; swine; zoonoses
- ... The in vitro 3D culture of intestinal epithelium is a valuable resource in the study of its function. Organoid culture exploits stem cells’ ability to regenerate and produce differentiated epithelium. Intestinal organoid models from rodent or human tissue are widely available whereas large animal models are not. Livestock enteric and zoonotic diseases elicit significant morbidity and mortality in ...