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1. Mammalian melatonin receptors: molecular biology and signal transduction

Author:
von Gall, Charlotte; Stehle, Jörg H.; Weaver, David R.
Source:
Cell and tissue research 2002 v.309 no.1 pp. 151-162
ISSN:
0302-766X
Subject:
G-proteins; adenosine monophosphate; circadian rhythm; cyclic AMP; gene expression; genes; guanylate cyclase; melatonin; mice; models; molecular biology; phosphorylation; polypeptides; receptors; reproduction; signal transduction; transcription factors
Abstract:
... The pineal hormone, melatonin, is an important regulator of seasonal reproduction and circadian rhythms. Its effects are mediated via high-affinity melatonin receptors, located on cells of the pituitary pars tuberalis (PT) and suprachiasmatic nucleus (SCN), respectively. Two subtypes of mammalian melatonin receptors have been cloned and characterized, the MT1 (Mel₁ₐ) and the MT2 (Mel₁b) melatonin ...
DOI:
10.1007/s00441-002-0581-4
PubMed:
12111545

2. Molecular machinery of the circadian clock in mammals

Author:
Okamura, Hitoshi; Yamaguchi, Shun; Yagita, Kazuhiro
Source:
Cell and tissue research 2002 v.309 no.1 pp. 47-56
ISSN:
0302-766X
Subject:
animal behavior; biological clocks; cell biology; circadian rhythm; genes; mammals; molecular biology; monitoring; physiology; translation (genetics)
Abstract:
... The discovery of clock genes and the general principle of their oscillation has stimulated research on biological clocks and this research has had a major impact on the field of life sciences. The mammalian circadian core oscillator is thought to be composed of an autoregulatory transcription-(post)translation-based feedback loop involving a set of clock genes. The real time monitoring of clock ge ...
DOI:
10.1007/s00441-002-0572-5
PubMed:
12111536