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- von Gall, Charlotte; Stehle, Jörg H.; Weaver, David R.
- Cell and tissue research 2002 v.309 no.1 pp. 151-162
- G-proteins; adenosine monophosphate; circadian rhythm; cyclic AMP; gene expression; genes; guanylate cyclase; melatonin; mice; models; molecular biology; phosphorylation; polypeptides; receptors; reproduction; signal transduction; transcription factors
- ... The pineal hormone, melatonin, is an important regulator of seasonal reproduction and circadian rhythms. Its effects are mediated via high-affinity melatonin receptors, located on cells of the pituitary pars tuberalis (PT) and suprachiasmatic nucleus (SCN), respectively. Two subtypes of mammalian melatonin receptors have been cloned and characterized, the MT1 (Mel₁ₐ) and the MT2 (Mel₁b) melatonin ...
- Hannibal, Jens
- Cell and tissue research 2002 v.309 no.1 pp. 73-88
- agonists; antagonists; biological clocks; brain; circadian rhythm; ganglia; genes; glutamic acid; immunohistochemistry; in vitro studies; mammals; neurotransmitters; photoreceptors; physiology; polypeptides
- ... The brain's biological clock, which, in mammals, is located in the suprachiasmatic nucleus (SCN), generates circadian rhythms in behaviour and physiology. These biological rhythms are adjusted daily (entrained) to the environmental light/dark cycle via a monosynaptic retinofugal pathway, the retinohypothalamic tract (RHT). In this review, the anatomical and physiological evidence for glutamate and ...