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- von Gall, Charlotte; Stehle, Jörg H.; Weaver, David R.
- Cell and tissue research 2002 v.309 no.1 pp. 151-162
- G-proteins; adenosine monophosphate; circadian rhythm; cyclic AMP; gene expression; genes; guanylate cyclase; melatonin; mice; models; molecular biology; phosphorylation; polypeptides; receptors; reproduction; signal transduction; transcription factors
- ... The pineal hormone, melatonin, is an important regulator of seasonal reproduction and circadian rhythms. Its effects are mediated via high-affinity melatonin receptors, located on cells of the pituitary pars tuberalis (PT) and suprachiasmatic nucleus (SCN), respectively. Two subtypes of mammalian melatonin receptors have been cloned and characterized, the MT1 (Mel₁ₐ) and the MT2 (Mel₁b) melatonin ...
- Stehle, Jörg H.; von Gall, Charlotte; Korf, Horst-Werner
- Cell and tissue research 2002 v.309 no.1 pp. 173-182
- adenosine; adenosine monophosphate; brain; cyclic AMP; gene expression; gene expression regulation; genes; melatonin; mice; pineal body; signal transduction
- ... In all vertebrates melatonin is rhythmically synthesised in the pineal gland and functions as a hormonal message encoding for the duration of darkness. This review focuses on the role of melatonin in the circadian organisation of mammals by comparing signal transduction mechanisms in the pineal organ, the suprachiasmatic nucleus and the hypophyseal pars tuberalis in melatonin-proficient (C3H) and ...